Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain

Abstract

The problem of noise has recently gained more attention as it has become an integral part of our daily lives. However, its influence has yet to be fully elucidated. Other than being an unpleasant stimulus, noise may cause health disorders through annoyance and stress, including oxidative stress. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, may possess antioxidant properties. Based on rat models, our project investigates the effect of rosuvastatin on noise-induced oxidative stress in the brain tissue. Thirty-two male Wistar albino rats were used. The rats were divided into four groups: Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage, and control. After the data had been collected, oxidant and antioxidant parameters were analyzed in the cerebral cortex, brain stem, and cerebellum. Results indicated that superoxide dismutase values were significantly decreased in the cerebral cortex, while malondialdehyde values in the brainstem and cerebellum were significantly increased in the group with only noise exposure. Superoxide dismutase values in the brainstem were significantly increased, but nitric oxide values in the cerebellum and brainstem and malondialdehyde values in the cerebellum and cerebral cortex were significantly decreased in the group where only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased superoxide dismutase values in the cerebral cortex and brainstem, but significantly reduced malondialdehyde values in the brain stem. Consequently, our data show that brain tissue was affected by oxidative stress due to continued exposure to noise. This noise-induced stress decreases with rosuvastatin therapy.

The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk

“…Also, oxidative DNA damage (detected by the comet assay) was observed in the rat heart and adrenal gland on noise exposure ≥100 dB(A) ( 86 , 139 ). Cardiovascular therapy using the cholesterol lowering substance rosuvastatin effectively prevented these adverse effects ( 70 ).…”

Effects of α lipoic acid on noise induced oxidative stress in rats

“…Ambient noise can impair productivity, auditory health, and perceptions of employees and result in negative physiological and psychological consequences (Güvercin and Aybek, 2003). As the noise levels increase and the exposure to noise is lengthened, it becomes possible to observe the negative effects on the cardiovascular, gastrointestinal, endocrine, and nervous systems (Akyıldız, 1980, Ersoy et al, 2014). In most businesses, noise levels can reach the upper noise limits that may impair the employees' health.…”

The Effect of Noise in the Intensive Care Unit on the Oxidative Stress Response in Rats

“…In prior experimental studies in rats, researchers found MDA level to be high and SOD activity to be low with chronic noise exposure (100 dB for 4 hr/day over 20 days; Koc et al, 2015). Another group of researchers exposed rats to noise levels of 100 dB 4 hr/per day for 20 days and investigated oxidant and antioxidant parameters in both blood and brain tissue (Ersoy et al, 2014). They reported that SOD activity in both serum and brain tissue was significantly lower and MDA level in brain tissue was significantly higher in the noiseexposed group compared to the other groups.…”