Effects of α lipoic acid on noise induced oxidative stress in rats

Abstract

This study was conducted to identify how exposure to ambient noise that is over 75 dB affects the oxidant-antioxidant profile using hematological and biochemical indicators, and to investigate the effects of a strong and current antioxidant, lipoic acid, on rats that were subjected to noise stress. For this purpose, five groups of eight rats were formed as follows: Control (K), Noise Exposure (GK), Lipoic Acid (LA), Noise Pollution + Lipoic Acid (GK + LA) and Oil (Y). The blood samples collected from rats were analyzed and MDA (malondialdehyde), GSH (glutathione), SOD (superoxide dismutase), CAT (catalase), NO (nitrit oxide), GPx (glutathione peroxidase), leukocytes, monocytes, lymphocytes, erythrocytes, hemoglobin, hematocrit, glucose, cholesterol, total protein, triglycerides, HDL (high density lipoprotein), LDL (low density lipoprotein), and urea-N levels were measured. The physical factory environment in a textile factory was preferred to simulate the noise exposure. Ambient noise was measured to be 75 dB. Exposure to physical ambient noise was sustained for 30 days. MDA level was measured at the lowest level in the LA and GKLA groups while it was statistically significantly higher in other groups than it was in the control group. It was observed that GSH reached its lowest level in the group that was exposed to noisy environment, the 100 mg/kg/day lipoic acid administered on the experimental model increased this level to that of the control group and this change was statistically significant ( p < 0.05). Considering the urea levels, the increases in GK and GKLA groups and the decreases in LA and Y groups were observed to be statistically significant. When glucose levels were compared to the control group, they were found to be statistically significantly lower in all groups. As a result, it was observed that exposure to noise for 30 days was likely to lead to leukocyte-based immune deficiency and using lipoic acid as an antioxidant might provide a significant protection against the noise stress.

Vitamin C supplementation during chronic variable stress exposure modulates contractile functions of testicular artery and sperm parameters in male Wistar rats

“…However, groups supplemented with vitamin C during chronic variable stress exposure showed no significant increase in MDA. Karafakioğlu [25] reported increased levels of MDA in noise only model of stress exposure with lipoic antioxidant supplementation reducing the MDA activity. Similarly, oxidative stress induced by hypoxia in animals was reported to significantly increase MDA activity with selenium supplementation significantly decreasing MDA tissue and plasma activity [26].…”

The Immune System Can Hear Noise

“…As a stressor, noise can induce oxidative stress in the body and regulate the nervous system, circulatory system and endocrine system. It is known that some antioxidants, such as lipoic acid ( 36 , 37 ) and Scoparia dulcis ( 38 ) can reduce changes in humoral and cellular immunity caused by noise. Therefore, we speculate that the influence of noise on the immune system may be correlated with neuroendocrine regulation and oxidative stress, although its specific mechanism remains to be explored.…”

“…The result indicated the role of antioxidant, anti-stressor and immune stimulant activity of SD. Furthermore, other antioxidants also show similar therapeutic effects against noise such as vitamins A or E (tocopherols) and α lipoic acid ( 36 ).…”

Müziğin strese bağlı indüklenen hormonlar ve oksidatif stres üzerine etkisi

“…In the both human and animal experiments, it was noted that exposure to noise increases peroxidation of lipids and alters the antioxidant enzyme levels 26 . In an animal study, it was also found that the oxidative stress indicator increased as a result of exposure to a noisy environment 27 . Supporting to these evidences, we observed a significant increase in the oxidative stress level in the rats exposed to the rock music.…”