Possible Gatifloxacin-Induced Hypoglycemia

Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice

“…Recently, hypoglycemia associated with the administration of FQs such as enoxacin (ENX), 1-3 lomefloxacin (LFLX), 4 and gatifloxacin (GFLX) [5][6][7] has been reported. However, the mechanism of hypoglycemia induced by FQs remains controversial.…”

“…Hypoglycemia during treatment with ENX, LFLX, and GFLX has been reported. [1][2][3][4][5][6][7] In Japan, because hypoglycemia associated with GFLX has been reported, administration of GFLX is now contraindicated for diabetic patients under the regulation of the Ministry of Health, Labour and Welfare. 7 However, which FQ has hypoglycemic activity remains unknown.…”

Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period

“…The strongest linkage is present with gatifloxacin. Numerous case reports have documented hypoglycemia and hyperglycemia with gatifloxacin [8][9][10]. A populationbased nested case-control series from Canada documented increased risk of in-patient treatment for hypoglycemia and hyperglycemia among patients receiving gatifloxacin as outpatients.…”

What Role do Fluoroquinolone Antimicrobial Agents Play in Cardiac Dysfunction and Altered Glycemic Control?

“…As with other quinolone agents, it has been suggested that blood glucose be monitored in diabetics receiving gatifloxacin concomitantly with insulin or oral hypoglycemic agents. 15,40,41 Signs and symptoms of hypoglycemia should be monitored, especially during the first 3 days of therapy, and signs and symptoms of hyperglycemia should be monitored in diabetic and other patients who may be at risk, especially following the third day of therapy. If signs and symptoms of either hypoglycemia or hyperglycemia occur in any patient being treated with gatifloxacin, appropriate therapy must be initiated immediately and the drug discontinued.…”