Possible involvement of GABAA-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice

Lolli, Luíz Fernando; Sato, Cláudia M.; Romanini, C; Villas-Boas, Larissa De Biaggi; Santos, Cid Aimbiré de Moraes; Oliveira, Rúbia Maria Weffort de

doi:10.1016/j.jep.2006.11.021

Cited by 49 publications

(36 citation statements)

References 40 publications

(47 reference statements)

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“…The test results reported in this article also confirmed that isoorientin possessed CNS effects. According to the results in this paper and other reports (Lolli et al, 2007;Santos et al, 2006), there is a conjecture that the effects of flavonoids as CNS active substances are related to the dose administered, namely, anxiolytic-like activity at lower dose and sedative-like activity at higher dose are observed.…”

Section: Spontaneous Activity Testsupporting

confidence: 57%

Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa

Deng

Zhou

Bai

et al. 2010

Journal of Ethnopharmacology

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Section: Spontaneous Activity Testsupporting

confidence: 57%

Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa

Deng

Zhou

Bai

et al. 2010

Journal of Ethnopharmacology

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“…Passiflora incarnata Linneaus is included in the nine plants for which there is considerable evidence of therapeutic effect, and is marketed in Western countries [15]. The sedative and anxiolytic activities of Passiflora incarnata Linneaus have been attributed to benzodiazepine and c-aminobutyric acid receptor-mediated biochemical processes in the body [16,17]. There are many different preparations of Passiflora incarnata Linneaus that vary considerably in their constituents.…”

Section: Discussionmentioning

confidence: 99%

Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia

et al. 2011

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“…Potentiation of pentobarbital-induced loss of righting reflex can be elicited through interaction with different neurotransmitter systems, namely GABA [40,41] or 5-HT [42]. In our tests, the reduced latency time for the pentobarbital-induced loss of righting reflex elicited by luteolin (0.1, 5 and 10 mg/kg) and the increase in the total duration of this effect (10 mg/kg) can be interpreted as an indication of luteolin's possible interference with these systems.…”

Section: Discussionmentioning

confidence: 99%

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

Coleta

Campos

Cotrim

et al. 2008

Behavioural Brain Research

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Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA A receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Luteolin (3 ,4 ,5,7-tetrahydroxyflavone) is a widespread flavonoid aglycon that was reported as devoid of specific affinity for benzodiazepine receptor (BDZ-R) binding site, but its psychopharmacological activity is presently unknown. Considering (1) the close structural similarity with other active flavones, (2) the activity of some of its glycosilated derivatives and (3) the complexity of flavonoid effects in the central nervous system, luteolin was submitted to a battery of tests designed to evaluate its possible activity upon the CNS and its ability to interact with the BDZ-receptor binding sites was also analysed.Luteolin apparently has CNS activity with anxiolytic-like effects despite the low affinity for the BDZ-R shown in vitro. Our findings suggest a possible interaction with other neurotransmitter systems but we cannot rule out the possibility that luteolin's metabolites might show a higher affinity for the BDZ-R in vivo, thus eliciting the evident anxiolytic-like effects through a GABAergic mechanism.

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Possible involvement of GABAA-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice

Cited by 49 publications

References 40 publications

Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa

Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa

Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

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