Possible involvement of melanin-concentrating hormone in food intake in a teleost fish, barfin flounder

Takahashi, Akiyoshi; Tsuchiya, Keisuke; Yamanome, Takeshi; Amano, Masafumi; Yasuda, Akikazu; Yamamori, Kunio; Kawauchi, Hiroshi

doi:10.1016/j.peptides.2004.02.022

Cited by 112 publications

(68 citation statements)

References 56 publications

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“…Interestingly, fish reared on a white background have a greater body length and weight (Takahashi et al 2004;Yamanome et al 2005). These observations suggest that the white background stimulates MCH production in the brain and this could in turn also affect the food intake in barfin flounder.…”

Section: Melanin-concentrating Hormone Receptor (Mchr) Of Barfin Floumentioning

confidence: 94%

“…The Arg 4 residue in the N-terminal sequence and Trp 15 residue in the C-terminal sequence, which are essential for binding to the receptor in humans, are conserved. The identification of bfMCH and bfN-proMCH in the pituitary extract demonstrates that the basic amino acids (Lys-Arg-Arg and Arg-Arg) act as processing signals (Takahashi et al 2004). In contrast to the high similarity in the MCH region between barfin flounder and other species, the remainder of the bf-proMCH shows a significant level of mutation in the amino acid sequence.…”

Section: Structurementioning

confidence: 97%

“…Fish reared on a white background have higher levels of MCH expression, brain concentration of MCH, and the number of MCH-ir cell body than those reared on a black background (Takahashi et al 2004;Amiya et al 2005). Interestingly, fish reared on a white background have a greater body length and weight (Takahashi et al 2004;Yamanome et al 2005).…”

Section: Melanin-concentrating Hormone Receptor (Mchr) Of Barfin Floumentioning

confidence: 99%

“…We investigated MCH system in barfin flounder for the better understanding of biological significance of MCH (Takahashi et al 2004). Nucleotide sequence of MCH cDNA was determined by conventional molecular cloning methods.…”

Section: Melanin-concentrating Hormone (Mch) Of Barfin Floundermentioning

confidence: 99%

“…In this sequence, MCH [6][7][8][9][10][11][12][13][14][15][16] has been shown to be sufficient for full activation of human MCHR1 and -R2 (Bednarek et al 2001). For fish MCH consisting of 17 aa, MCH 4-14 corresponds to the minimal sequence in mammals (Takahashi et al 2004). Fish MCH 4-14 is identical to mammalian MCH 6-16 excluding a replacement in one residue, Val at fish MCH 7 or Leu at mammalian MCH 9 .…”

Section: Structurementioning

confidence: 99%

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Multifunctional Roles of Melanocyte-Stimulating Hormone and Melanin-Concentrating Hormone in Fish: Evolution from Classical Body Color Change

Takahashi¹,

Mizusawa²,

Amano³

2014

Aqua-BioSci. Monogr. (ABSM)

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The representative role of melanocyte-stimulating hormone (MSH) and melaninconcentrating hormone (MCH) in fish is regulation of pigment migration. However, our studies using barfin flounder Verasper moseri, a flatfish as a major experimental fish, have revealed that MSH and MCH are multifunctional because their receptors are widely distributed not only in the melanophores but also in the brain and systemic body. Their biological roles other than control of pigment migration would be regulation of feeding behavior, energy metabolism, cortisol release, etc. Among them, an interesting biological process on molecular level has been observed in the role of α-MSH. A fine difference in the structure-presence or absence of one acetyl group-modified the activities. Namely, desacetyl-α-MSH having no acetyl group at N-terminal stimulates pigment dispersion in melanophore and cortisol release from the interrenal gland, while α-MSH having one acetyl group has negligible effects. On the whole body level, MCH probably transfers information about photic conditions from the external environment to the body. MCH production is changeable, depending on the difference in the intensity of the light. A white background enhances production of MCH, and MCH turns body color pale by aggregating pigments in scales. It is suggested that this peptide stimulates feeding behavior. This monograph reveals molecular characteristic and biological significance of MSH and MCH systems in fish.

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Section: Melanin-concentrating Hormone Receptor (Mchr) Of Barfin Floumentioning

confidence: 94%

Section: Structurementioning

confidence: 97%

Section: Melanin-concentrating Hormone Receptor (Mchr) Of Barfin Floumentioning

confidence: 99%

Section: Melanin-concentrating Hormone (Mch) Of Barfin Floundermentioning

confidence: 99%

Section: Structurementioning

confidence: 99%

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Multifunctional Roles of Melanocyte-Stimulating Hormone and Melanin-Concentrating Hormone in Fish: Evolution from Classical Body Color Change

Takahashi¹,

Mizusawa²,

Amano³

2014

Aqua-BioSci. Monogr. (ABSM)

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Pigmentation Physiology and Discoloration Problems

2011

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Differential distribution of hypocretin (orexin) and melanin‐concentrating hormone in the goldfish brain

Huesa¹,

Pol

Finger³

2005

J of Comparative Neurology

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The orexigenic peptides hypocretin (orexin) and melanin-concentrating hormone (MCH) are involved in the control of food intake and in other homeostatic functions including sleep and arousal. In this article we study the distribution of these peptides in the brain of the goldfish (Carassius auratus), focusing on those regions particularly related to feeding, sleep, and arousal. Although the general distribution of these peptides in goldfish shows many similarities to those described previously in other species, we observed some noteworthy differences. As in other vertebrates, the peptidergic somata lie in the anterolateral hypothalamus. In goldfish, both hypocretin and MCH immunoreactive cell bodies project fibers to the ventral telencephalon, thalamus, and hypothalamus. At mesencephalic levels fibers reach the deep layers of the optic tectum and also course sparsely through the mesencephalic tegmentum. In contrast to the strong innervation of locus coeruleus and raphe in mammal, the MCH and hypocretin systems in goldfish barely innervate these aminergic populations related to the regulation of sleep and arousal. MCH, but not hypocretin, immunoreactive fibers terminate substantially in the sensory layer of the vagal gustatory lobe of goldfish, while both peptidergic systems distribute to the primary visceral sensory areas of the medulla and pons. The strong involvement of these peptidergic systems with the hypothalamus and general visceral nuclei, but not with locus coeruleus or raphe nuclei support the view that these peptides originally played a role in regulation of energy balance and evolved secondarily to influence sleep-wakefulness systems in amniote vertebrates.

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Possible involvement of melanin-concentrating hormone in food intake in a teleost fish, barfin flounder

Cited by 112 publications

References 56 publications

Multifunctional Roles of Melanocyte-Stimulating Hormone and Melanin-Concentrating Hormone in Fish: Evolution from Classical Body Color Change

Multifunctional Roles of Melanocyte-Stimulating Hormone and Melanin-Concentrating Hormone in Fish: Evolution from Classical Body Color Change

Pigmentation Physiology and Discoloration Problems

Differential distribution of hypocretin (orexin) and melanin‐concentrating hormone in the goldfish brain

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