Possible mechanism for the anemia induced by candesartan cilexetil (TCV-116), an angiotensin II receptor antagonist, in rats

Naeshiro, Ichiro; Sato, Keiichiro; Chatani, Fumio; Sato, Shuzo

doi:10.1016/s0014-2999(98)00451-8

Cited by 31 publications

(25 citation statements)

References 22 publications

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“…In this model, a 2-week infusion of angiotensin II corrected the hematocrit to near wild-type levels, strongly implicating a direct role of angiotensin II in erythropoiesis. Consistent with this finding, angiotensin II receptor antagonists reduce hemoglobin, hematocrit, and erythrocyte counts in rats (Naeshiro et al, 1998).…”

Section: G Erythropoiesissupporting

confidence: 75%

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

et al. 2012

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Section: G Erythropoiesissupporting

confidence: 75%

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

et al. 2012

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“…In this regard, in early diabetes renal blood flow is increased, and it is plausible that resulting increased oxygen supply suppresses Epo production. In line with this, blockade of the renin-angiotensin system in rats increased interstitial blood flow (due to decreased intrarenal resistance) and anemia (60), possibly explaining the drop in hematocrit typically observed in the first month of therapy with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers in patients (61). While supplementation with recombinant Epo is highly effective, it is associated with high costs, and its effectiveness can be impaired by antibody formation.…”

Section: Impaired Epo Production As Cause Of Anemiamentioning

confidence: 86%

Physiology of the Renal Interstitium

Zeisberg

Kalluri

2015

Clinical Journal of the American Society of Nephrology

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Long overlooked as the virtual compartment and then strictly characterized through descriptive morphologic analysis, the renal interstitium has finally been associated with function. With identification of interstitial reninand erythropoietin-producing cells, the most prominent endocrine functions of the kidney have now been attributed to the renal interstitium. This article reviews the functional role of renal interstitium.

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“…For instance, the renin-angiotensin system stimulates the hematopoietic progenitor cell and induces the growth of early erythroid progenitors (24,25). ACE inhibitors and angiotensin II receptor antagonist might suppress erythropoiesis (26,27). In peritoneal dialysis patients, genotype II is associated with both lower ACE levels and higher EPO dose requirements (28,29).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Angiotensin-Converting Enzyme Gene Polymorphism and Body Composition, Functional Performance, and Blood Biomarkers in Advanced Cancer Patients

Viganò¹,

Trutschnigg²,

Kilgour

et al. 2009

Clinical Cancer Research

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Purpose: Nutritional and functional outcome measures have been shown to vary in patients with chronic diseases according to the polymorphic alleles of angiotensin-converting enzyme (ACE), but little is known about the associations between ACE gene polymorphism (ACEGP) and the components of body composition, strength, and selected blood markers in advanced cancer patients (ACP). Experimental Design: Data were collected from an inception cohort of 172 newly diagnosed ACP with gastrointestinal and non^small cell lung cancer. ACEGP status was defined by the presence of one of the following three combinations of alleles: insertion/insertion, insertion/deletion, and deletion/deletion. Body composition measurements using Dual-energy X-ray Absorptiometry comprised of the following: total fat mass, percent body fat, lean body mass, and appendicular lean mass. Body mass index; handgrip force by Jamar dynamometry; subjective recording of nutrition and performance status as per patient-generated subjective global assessment; cell blood count and differential, serum albumin, ACE, and C-reactive protein were also recorded. Results: Multiple regression analysis, controlling for gender, age, diagnosis, treatments (radio/ chemo), survival, and medication use (ACE inhibitors, anti-inflammatories, statins) revealed the following significant (P V 0.05) relationships in the insertion/deletion compared with insertion/ insertion group: higher hemoglobin (Hb; h, 6.39 g/dl; 95% confidence interval, 0.01-12.78), lower total fat mass (-5.78 kg; -11.62 to 0.07), percent body fat (-6.04%; -12.20 to 0.12), and lean body mass (-3.26 kg; -6.78 to 0.26).When comparing the DD to the II group, higher serum ACE (9.10; 1.96-16.25), Hb (6.25 g/dl; -0.63 to 13.12), and handgrip force by Jamar (6.85 lbs; 0.78-12.93) were found. Conclusion: Of the variables studied, ACEGP seems to be primarily associated with differences in body composition, Hb, and muscle strength in ACP. Further data are needed to determine the clinical effect of ACEGP in cancer cachexia.

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Possible mechanism for the anemia induced by candesartan cilexetil (TCV-116), an angiotensin II receptor antagonist, in rats

Cited by 31 publications

References 22 publications

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

Physiology of the Renal Interstitium

Relationship Between Angiotensin-Converting Enzyme Gene Polymorphism and Body Composition, Functional Performance, and Blood Biomarkers in Advanced Cancer Patients

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