Possible mechanisms for the renoprotective action of adipose-derived mesenchymal stem cells with CD44-targeted hyaluronic acid against renal ischemia

Therapeutic Effects of Stem Cells From Different Source on Renal Ischemia- Reperfusion Injury: A Systematic Review and Network Meta-analysis of Animal Studies

“…There were great differences in the types and sources of stem cells. Adipose Tissue-Derived Mesenchymal Stem Cells (ADMSCs) were derived from SD rats ( Chen et al, 2011 ; Gao et al, 2012 ; Masoud et al, 2012 ; Shih et al, 2013 ; Sheashaa et al, 2016 ; Zhou et al, 2016 ; Lam et al, 2017 ; Zhang et al, 2017 ; Changizi-Ashtiyani et al, 2020 ), Wistar rats ( Wang et al, 2013 ; Hussein et al, 2016 ; Zhao et al, 2016 ; Shi et al, 2018 ; Awadalla et al, 2021 ), humans ( Zhou et al, 2017 ; Huang et al, 2020 ), Fisher 344 rats ( Feng et al, 2010 ) and C57BL/6 mice ( Donizetti-Oliveira et al, 2011 ; Donizetti-Oliveira et al, 2012 ; Furuichi et al, 2012 ). Bone Marrow Derived Mesenchymal Stem Cells (MDMSCs) were derived from Lewis rats ( Erpicum et al, 2017 ), Wister rats ( Semedo et al, 2009 ; Havakhah et al, 2018 ), SD rats ( Lange et al, 2005 ; Wang et al, 2005 ; Wang and Fu, 2008 ; Tögel et al, 2009 ; Zhuo et al, 2011 ; Altun et al, 2012 ; Huang et al, 2012 ; Zhuo et al, 2013 ; Cai et al, 2014a ; Cai et al, 2014b ; Zhao et al, 2014 ; Wang et al, 2019 ), C57BL/6 mice ( Liu et al, 2011 ; Qi et al, 2014 ; Xie et al, 2015 ; Hu et al, 2016 ), BALB/C mice ( Xing et al, 2014 ), Rabbits ( Yang et al, 2008 ; Fang, 2009 ), Sheep ( Behr et al, 2007 ; Behr et al, 2009 ) and human ( Cao et al, 2010 ; Wise et al, 2014 ; Collett et al, 2017b ; Zilberman-Itskovich et al, 2019 ).…”

“…Among the 72 controlled studies included in the analysis, only one study reported specific randomized grouping methods for experimental animals ( Hu et al, 2016 ); 32 studies reported similar baseline characteristics of the experimental animals used; none of the studies reported the use of covert grouping ( Wang and Fu, 2008 ; Yang et al, 2008 ; Cao et al, 2010 ; Chen et al, 2011 ; Zhuo et al, 2011 ; Huang et al, 2012 ; Lee et al, 2012 ; Sadek et al, 2013 ; Shih et al, 2013 ; Zhuo et al, 2013 ; Cai et al, 2014b ; Tsuda et al, 2014 ; Xing et al, 2014 ; Zhao et al, 2014 ; Hattori et al, 2015 ; Li et al, 2015 ; Monteiro Carvalho Mori da Cunha et al, 2015 ; Hussein et al, 2016 ; Zhou et al, 2016 ; Fahmy et al, 2017 ; Lam et al, 2017 ; Rodrigues et al, 2017 ; Tian et al, 2017 ; Zhang et al, 2017 ; Havakhah et al, 2018 ; Ko et al, 2018 ; Shi et al, 2018 ; Zilberman-Itskovich et al, 2019 ; Huang et al, 2020 ; Li et al, 2020 ; Ren et al, 2020 ; Awadalla et al, 2021 ); and 35 studies reported randomization of animals during experiments. ( Lange et al, 2005 ; Semedo et al, 2009 ; Tögel et al, 2009 ; Wang et al, 2009 ; Zhuo et al, 2011 ; Donizetti-Oliveira et al, 2012 ; Du et al, 2012 ; Gao et al, 2012 ; Lee et al, 2012 ; Sadek et al, 2013 ; Shih et al, 2013 ; Wang et al, 2013 ; Zhuo et al, 2013 ; Cai et al, 2014a ; Ryoun et al, 2014 ; Gupta et al, 2015 ; Hattori et al, 2015 ; Li et al, 2015 ; Liang et al, 2015 ;...…”

“…The results of network meta-analysis showed that MDMSCs and ADMSCs had the highest number of studies ( Figure 3A ); There was no significant difference in the level of serum creatinine among different of stem cells, as detailed in Table 2 ; The comparison-correction funnel plot was asymmetric, suggesting that publication bias and small sample effect might exist ( Figure 3B ). The ranking results showed that Fetal Kidney Cells might be one of the most effective to reduce serum creatinine level ( Figure 3C ); ②7 days after administration: 20 studies were included for data analysis ( Donizetti-Oliveira et al, 2012 ; Changizi-Ashtiyani et al, 2020 ; Ryoun et al, 2014 ; Furuichi et al, 2012 ; Liang et al, 2015 ; Gupta et al, 2015 ; Rodrigues et al, 2017 ; Tian et al, 2017 ; Havakhah et al, 2018 ; La Manna et al, 2011 ; Hussein et al, 2016 ; Awadalla et al, 2021 ; Zhao et al, 2014 ; De Chiara et al, 2014 ; Fahmy et al, 2017 ; Zhao et al, 2016 ; Li et al, 2015 ; Liu et al, 2011 ; Fang, 2009 ; Yang et al, 2008 ). The results of traditional meta-analysis were detailed in Table 3 , showed that that serum creatinine levels in various of stem cell groups were lower than those in the negative control group.…”

“…The results of network meta-analysis showed that MDMSCs and ADMSCs had the highest number of studies ( Figure 4A ); ADMSCs showed better therapeutic effect than other types of stem cells, as detailed in Table 4 ; The comparison-correction funnel plot was asymmetric, suggesting that publication bias and small sample effect might exist ( Figure 4B ); The ranking results showed that UCMSCs might be one of the most effective stem cells to reduce serum creatinine level ( Figure 4C ). ③14 days after administration: 12 studies were included for data analysis ( Yang et al, 2008 ; Fang, 2009 ; Liu et al, 2011 ; Donizetti-Oliveira et al, 2012 ; Gao et al, 2012 ; De Chiara et al, 2014 ; Ryoun et al, 2014 ; Lewin et al, 2015 ; Li et al, 2015 ; Rodrigues et al, 2017 ; Havakhah et al, 2018 ; Awadalla et al, 2021 ). The results of traditional meta-analysis were detailed in Table 5 , showed that no significant difference in serum creatinine levels between stem cell groups and negative control group except RPCs.…”

“…①1 day after administration: 36 studies were included for data analysis ( Chen et al, 2011 ; Erpicum et al, 2017 ; Guo and Wang, 2018 ; Ryoun et al, 2014 ; Bo et al, 2013 ; Zhuo et al, 2013 ; Liang et al, 2015 ; Behr et al, 2009 ; Gupta et al, 2015 ; Sadek et al, 2013 ; Rodrigues et al, 2017 ; Tian et al, 2017 ; Havakhah et al, 2018 ; Behr et al, 2007 ; Cai et al, 2014b ; Zhuo et al, 2011 ; Hu et al, 2013 ; Cao et al, 2010 ; La Manna et al, 2011 ; Xing et al, 2014 ; Hussein et al, 2016 ; Awadalla et al, 2021 ; Zhou et al, 2016 ; Zhao et al, 2014 ; Chen et al, 2013 ; Donizetti-Oliveira et al, 2011 ; Fahmy et al, 2017 ; Hattori et al, 2015 ; Zhao et al, 2016 ; Tsuda et al, 2014 ; Li et al, 2015 ; Gao et al, 2012 ; Altun et al, 2012 ; Liu et al, 2011 ; Wang et al, 2005 ; Wang and Fu, 2008 ). The results of traditional meta-analysis were detailed in Table 7 , showed that blood urea nitrogen levels in different types of stem cell groups were lower than those in the negative control group.…”