2018
DOI: 10.1016/bs.ant.2018.03.004
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Possible Mechanisms of Developmental Neurotoxicity of Organophosphate Insecticides

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Cited by 2 publications
(4 citation statements)
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“…The obtained IC 50 values of the pine branches scCO 2 extracts revealed their possible action as insecticides/larvicides. Despite the lower IC 50 values showed by the extracts when compared to the commercial organophosphates, it should be taken into account that both used standards are pro-insecticides that require oxidative desulfuration for the corresponding oxon to be active [15]. Therefore, the IC 50 values obtained in vitro for the standards may be lower in vivo.…”
Section: Ache Inhibitory Activitymentioning
confidence: 95%
See 1 more Smart Citation
“…The obtained IC 50 values of the pine branches scCO 2 extracts revealed their possible action as insecticides/larvicides. Despite the lower IC 50 values showed by the extracts when compared to the commercial organophosphates, it should be taken into account that both used standards are pro-insecticides that require oxidative desulfuration for the corresponding oxon to be active [15]. Therefore, the IC 50 values obtained in vitro for the standards may be lower in vivo.…”
Section: Ache Inhibitory Activitymentioning
confidence: 95%
“…Yet, their lack of selectivity, repeated use and residual contamination have been poisoning nontargeted organisms and increasing resistance in insects [12,13]. As a consequence, synthetic insecticides pose a risk both to the environment and to public health [14,15]. Commonly used synthetic insecticides, like organophosphates and carbamates, have their mechanism of toxicity based on the inhibition of acetylcholinesterase (AChE) [16].…”
Section: Introductionmentioning
confidence: 99%
“…The indefinite effects of the threshold dose for brain AChE inhibition on locomotor activity could be attributed to the variability in cholinergic pathway inhibition, including brain, red blood cell, and plasma ChE in relation to CPF metabolism via other pathways (e.g., endocannabinoid, serotonergic, or dopaminergic pathways) (Aldridge, Levin, et al, 2005;Aldridge, Meyer, et al, 2005;Carr et al, 2017Carr et al, , 2018. Moreover, they could be attributed to variability in neural plasticity and repair after removal of CPF exposure.…”
Section: Ratsmentioning
confidence: 99%
“…For example, decreased locomotor activity, neuromotor function (NMF), cognition, anxiety/depression, and social behaviors induced by CPF exposure to children during early development could be modeled in rodents. In rodents, CPF exposure during critical neurodevelopment stages has been associated with disruptions in the endocannabinoid (Buntyn et al, ; Carr et al, ; Carr, Alugubelly, & Mohammed, , chap. 5; Qiao, Seidler, & Slotkin, ; Qiao, Seidler, Tate, Cousins, & Slotkin, ; Zheng, Olivier, Won, & Pope, ), dopaminergic (Aldridge, Meyer, Seidler, & Slotkin, ), and serotonergic systems (Aldridge, Levin, Seidler, & Slotkin, ; Aldridge, Seidler, Meyer, Thillai, & Slotkin, ; Aldridge, Seidler, & Slotkin, ).…”
Section: Introductionmentioning
confidence: 99%