Possible mechanisms of diabetic fetopathy

Poletaev, Alexander B.; Gnedenko, B.B.; Makarova, A A; Krasnopolsky, V. I.; Будыкина, Т. С.; Petrukhin, V. A.; Morozov, Sergey G.

doi:10.3233/hab-2000-9401

Cited by 9 publications

(4 citation statements)

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“…41,42 Less well understood is the finding and relevance of decreased autoantibodies; however, associations and findings are now beginning to emerge in both the neurologic and diabetic disorders. 43,44 Nevertheless, we demonstrated changes in the natural autoantibody profiles of patients with glaucoma as evidenced by altered serum immunoreactivities to both previously identified autoantigens and the newly identified autoantigen ␣-fodrin. We emphasize that it is premature to speculate that the changes we found in autoantibody profiles are pathogenic, epiphenomena, or a consequence of glaucomatous optic neuropathy.…”

Section: Discussionmentioning

confidence: 76%

Serum Autoantibodies to α-Fodrin Are Present in Glaucoma Patients from Germany and the United States

Grus¹,

Joachim²,

Bruns

et al. 2006

Invest. Ophthalmol. Vis. Sci.

112

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Complex IgG antibody patterns against optic nerve antigens can be reproducibly identified in the serum of study populations from the United States and Germany. In both cohorts, patients with glaucoma have characteristic differences in serum autoantibody repertoires from those in control subjects. A newly described autoantibody to alpha-fodrin found in other neurodegenerative diseases such as Alzheimer's, further implicate a role for autoimmunity and the neurodegenerative processes in glaucoma. The high correspondence of the autoantibody patterns found in the study populations from different continents provides further evidence that serum autoantibody patterns may be useful biomarkers for glaucoma detection or for determining prognosis in future studies by means of pattern-matching algorithms.

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Section: Discussionmentioning

confidence: 76%

Serum Autoantibodies to α-Fodrin Are Present in Glaucoma Patients from Germany and the United States

Grus¹,

Joachim²,

Bruns

et al. 2006

Invest. Ophthalmol. Vis. Sci.

112

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“…The range of histological changes is ill-defined as with the stabilization of the condition of the fetus postpartum, most of them tend to regress [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Histological Changes in Severe Diabetic Fetopathy: An Autopsy Case Report

Stoyanov

Kobakova

Stoev

et al. 2019

Cureus

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Maternal diabetes is one of the most common and dangerous risk factors during pregnancy, as often there are no generalized signs. Diabetic fetopathy is a severe, poorly defined complication of gestational diabetes or preexisting maternal diabetes mellitus, with an ill-defined histological spectrum of changes. Herein we report a case of severe diabetic fetopathy diagnosed upon autopsy of a recently miscarried fetus. On histology, the liver revealed severe generalized macrovesicular steatosis and number of small cysts. The pancreas revealed not only Langerhans isle hyperplasia, but also Langerhans amyloidosis, evident of the severity of maternal diabetes and fetal hyperglycemia. The adrenal glands revealed hyperplasia in zona glomerulosa, due to aldosterone overproduction, evident of fetal hypertension. The current case is an extreme example of an undiagnosed and untreated gestational diabetes mellitus. The severity of histological changes, in this case, is suggestive of further extension of the diagnostic criteria of diabetic fetopathy to include more subtle changes that can be observed clinically and even a combination of maternal-newborn factors.

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“…Одной из основных причин нарушения здоровья новорожденных от женщин с сахарным диабетом 1 типа (СД1) -диабетическая фетопатия с задержкой развития всех систем организма, но в первую очередь -центральной нервной системы [1]. Ранее была выявлена взаимосвязь между развитием осложнений как самого гестационного процесса при СД1, так и неблагоприятных перинатальных исходов с повышением содержания антител к инсулину (идиотипических и антиидиотипических -АТ1-И и АТ2-И соответственно) [2].…”

Section: Introductionunclassified

Effect of a complex therapy including a nonspecific immune correction in pregnant women with type 1 diabetes mellitus on the health status of their children

Папышева¹,

Будыкина²,

Protsenko³

et al. 2018

Nauchno-Prakticheskii Zhurnal «Patogenez»

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Цель. Влияние комплексной терапии с включением неспецифической иммунокоррекции (ингаляции гепарина в гестационном периоде у женщин с сахарным диабетом 1-го типа (СД1) с установленной гиперпродукцией аутоантител к инсулину и его рецепторам), на здоровье рожденных ими детей. Материалы и методы. Проведен сравнительный анализ нервно-психического развития, соматического состояния и иммунологических особенностей у детей от рождения до 3 лет от матерей с СД1, получавших традиционную терапию (основная группа, n = 101) и детей от матерей с СД1, получавших во время беременности в составе комплексной терапии ингаляции гепарином (экспериментальная группа, n = 40). Контрольную группу (n = 30) составили дети от соматически здоровых матерей без инфекционной и эндокринной патологии. Результаты. При анализе частоты регистрируемой у детей в период новорожденности патологии ЦНС установлено увеличение данного показателя по сравнению с контролем обеих группах детей, рождённых от матерей с СД1. Однако по результатам балльной оценки (методика «ГНОМ») выявлено, что в экспериментальной группе было достоверно больше здоровых детей и, наоборот, меньше детей с патологией нервной системы, нуждающихся в лечении. При этом что уровень антител к инсулину у детей экспериментальной группы в возрасте 1 год оказался значимо ниже (р < 0,05), чем в основной группе. Заключение. Своевременное применение неспецифической иммунокоррекции в период беременности в составе комплексной терапии беременных женщин с СД1 позволяет нормализовать уровень органоспецифических аутоантител, улучшить клиническое состояние новорожденных детей и прогноз их последующего неврологического развития. Aim. To study the effect of a complex therapy including a nonspecific immune correction (heparin inhalation in the gestational period of women with type 1 diabetes mellitus (DM1) with documented overproduction of insulin and insulin receptor autoantibodies) on the health of their children. Methods. A comparative analysis of neuropsychic development, somatic status, and immunological features was performed in children from birth to three years born by mothers with DM1 who received a standard complex therapy (main group, n = 101) and children from mothers with DM1 who received heparin inhalation as a part of the complex therapy during pregnancy (study group, n = 40). The control group (n = 30) consisted of children from somatically healthy mothers without infectious and endocrine pathology. Results. Analysis of the incidence of CNS pathology observed in newborns during the neonatal period showed an increase in this index in both groups of children born from mothers with DM1 compared to the control. However, according to the results of scoring (GNOM method) the number of healthy children was significantly greater whereas the number of children with CNS pathology who needed treatment was significantly less. Moreover, the level of insulin antibodies was significantly lower (p <0.05) in children of the experimental group at the age of one year than in the main group. Conclusion. The timely use of nonspecific immune correction as a part of the complex therapy of pregnant women with DM1 allows to normalize the level of organ-specific autoantibodies, improve both the clinical condition of newborns and the prediction for their subsequent neurological development.

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Possible mechanisms of diabetic fetopathy

Cited by 9 publications

References 0 publications

Serum Autoantibodies to α-Fodrin Are Present in Glaucoma Patients from Germany and the United States

Serum Autoantibodies to α-Fodrin Are Present in Glaucoma Patients from Germany and the United States

Histological Changes in Severe Diabetic Fetopathy: An Autopsy Case Report

Effect of a complex therapy including a nonspecific immune correction in pregnant women with type 1 diabetes mellitus on the health status of their children

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