Possible Prognostic Markers in Conjunctival Dysplasia and Squamous Cell Carcinoma

Aoki, Seiko; Kubo, Eri; Nakamura, Seigo; Tsuzuki, Akiko; Tsuzuki, Shosai; Takahashi, Yukio; Akagi, Yoshio

doi:10.1016/s0021-5155(98)00017-3

Cited by 16 publications

(13 citation statements)

References 16 publications

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“…At least 90% of the basal cells in limbal and peripheral corneal epithelia synchronously progress through the cell cycle. These inhibitors specifically block cells in the G1 phase of the cell cycle [1,16,19]. This study aimed to investigate the correlation between MIB-1, cell proliferative activity, and p16, p53, and p63 overexpression in conjunctiva SCC.…”

Section: Discussionmentioning

confidence: 99%

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Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infection

Jung¹,

Lin²,

Chu³

et al. 2005

Virchows Arch

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Squamous cell carcinoma (SCC), the most common primary malignant tumor of the conjunctiva, has a variable clinical presentation and immunohistochemical profile. Abundant cell cycles exist, including MIB-1 (Ki67 antigen), p16, p53, and p63, within the conjunctiva SCC. This investigation first reports the expressions of cell cycle markers in SCC. A retrospective study was conducted between December 1976 and June 2004, comprising 13 consecutive patients with conjunctiva SCC who were treated with surgical excision. Detailed clinical parameters were also reviewed. Overexpression of MIB-1, p16, p53, and p63 genes were studied by immunohistochemistry. Genechip containing 39 subtypes was used to elucidate human papillomavirus (HPV). The study group contained 13 (100%) men, with a mean age of 68+/-18 years and follow-up period of 20+/-17 months. The sample included four (33%) SCC located in the left eye and two (17%) recurrent SCC. Overexpression of the p53 and p63 was considerably higher than that of the p16 (P<0.01). HPV DNA was not detected in any of the 13 cases. This work first examined the immunohistochemical overexpression of cell cycle (MIB-1, p16, p53, and p63) in SCC. This investigation then showed that the expression of cell cycles in SCC was associated with key tumor clinicopathological features. This approach can help distinguish the potential roles of cell cycle in the development of SCC.

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Section: Discussionmentioning

confidence: 99%

“…SCC also is associated with numerous cell cycle genes [1,16,22]. Cell cycle genes vary during cell proliferation and apoptosis [8,9,19,20,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infection

Jung¹,

Lin²,

Chu³

et al. 2005

Virchows Arch

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“…As a cofactor in DNA polymerase delta and DNA replication, proliferating cell nuclear antigen (PCNA) 4,10,19,20 expression has been a useful marker of cell proliferation in both normal and neoplastic tissues. PCNA is induced during the cell-cycle transition from G0 to G1 phase, further increasing during S phase.…”

Section: Discussionmentioning

confidence: 99%

Ki-67 Labeling Index as a Marker of Malignancy in Ocular Surface Neoplasms

et al. 2004

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“…Moreover, proliferating cell nuclear antigen (PCNA), Ki-67 and p53 immunostaining as well as argyrophillic nucleolar organizer region (AgNOR) staining may be useful for grading the dysplastic lesions as well as for correlation with clinical morphologic findings. (Aoki et al 1998) Grading of dysplasia is described as:  Mild -less than a third thickness of the epithelium is occupied by atypical cells. (Fig.12A) www.intechopen.com  Moderate -within three quarters thickness of the epithelium is occupied by atypical cells.…”

Section: Histologymentioning

confidence: 99%