Possible regeneration of the islets of langerhans in streptozotocin-diabetic rats given gymnema sylvestre leaf extracts

Shanmugasundaram, E. R. B.; Gopinath, K.Leela; Shanmugasundaram, K. Radha; Rajendran, V.

doi:10.1016/0378-8741(90)90106-4

Cited by 219 publications

(129 citation statements)

References 10 publications

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“…No adverse reactions were reported in a long-term study of insulin-dependent diabetic patients (Shanmugasundaram et al, 1990). However, consider the possibility of hypoglycemia.…”

Section: Toxicological and Safety Evaluationmentioning

confidence: 99%

“…A more dramatic effect was noted when the extract was administered parenterally to rats (Gupta and Variyar, 1964). Shanmugasundaram et al, (1990) investigated that patients received 200 mg Gymnema powder twice daily in addition to their usual doses of insulin, mean glycosylated hemoglobin (HbA 1c) decreased significantly from baseline (12.8 to 9.5%) at 6 months in a controlled trial of patients with type 1 diabetes. Mozersky, (1999) reported that 22 patients were given G. sylvestre extract along with their oral hypoglycemic drugs.…”

Section: Hypoglycemic Activity or Antihyperglycemic Activitymentioning

confidence: 99%

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Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes

Thakur¹

2012

J. App. Pharm. Sci.

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Gymnema sylvestre (Asclepiadaceae) also known as 'gurmar' or 'sugar destroyer' is a woody, climbing traditional medicinal herb which has many therapeutic applications in Ayurvedic system of medicine. It is used for lowering serum cholesterol, triglycerides and blood glucose level (hypoglycemic or antihyperglycemic), hypolipidaemic, weight loss, stomach ailments, constipation, water retention and liver diseases, either high or low blood pressure, tachycardia or arrhythmias, and used as aperitive, purgative, in eye troubles, antiinflammatory, smooth muscle relaxant, prevention of dental caries, cataract and as anticancer-cytotoxic agent. Its flowers, leaves, and fruits contains alkaloids, flavones, saponins, sapogenins, anthraquinones, hentri-acontane, pentatriacontane, α and β-chlorophylls, phytin, resins, d-quercitol, tartaric acid, formic acid, butyric acid, lupeol, β-amyrin related glycosides and stigmasterol having main principle bioactive compunds viz. gymnemic acids, gymnemasides, gymnemagenin, gurmarin, gymnemosides, gymnemanol, gymnemasins, gypenoside, and conduritol which act as therapeutic agent and play vital role in many therapeutic applications. Gymnemic acids are thought to be responsible for its antidiabetic activity and it is the major component of an extract shown to stimulate insulin release from the pancreas. Another anti-sweet agent gumarin is utilized as a pharmacological tool in the study of sweet-taste transduction. The commercial exploitation of this plant and their secondary metabolites are some of the major prospective of this rare medicinal herb. The focus of the present review is to achieve the potential of therapeutic value of this herb and mechanism and action of their secondary metabolites.

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“…No adverse reactions were reported in a long-term study of insulin-dependent diabetic patients (Shanmugasundaram et al, 1990). However, consider the possibility of hypoglycemia.…”

Section: Toxicological and Safety Evaluationmentioning

confidence: 99%

Section: Hypoglycemic Activity or Antihyperglycemic Activitymentioning

confidence: 99%

Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes

Thakur¹

2012

J. App. Pharm. Sci.

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“…Two animal studies on beryllium nitrate & streptozotocin --diabetic rats found that the G. sylvestre extracts to double the insulin-secreting beta cells number in pancreas &to return BS to almost normal. 12,13 Gymnema sylvestre increases the enzymes that are responsible for the uptake of glucose & utilization, 14 and inhibits glucose peripheral utilization by somatotropin & corticotrophin. 15 In India Gymnema sylvestre leaves, called "Gurmar", and are most popular for their sweet taste suppressing activity& are used for the diabetes mellitus treatment forover 2000 year, hence the name "Gurmar" meaning 'sugar destroying' to it.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hypoglycemic Property of Gurmar (Gymnema Sylvestre) Leaves Methanolic Extract (GSLME) in Streptozocin (STZ) induced Diabetic Albino Rats

Sk¹

2017

jmscr

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“…The plant extracts are also used in folk, ayurvedic and homeopathic systems of medicine [3]. The extract of G. sylvestre plays a major role in blood glucose homeostasis through increased serum insulin level via β-cells regeneration of the endocrine pancreas [4,5]. In Japan, Gymnema Teas and Gymnema chewing gum are being made from G. sylvestre leaves and promoted as a natural method for controlling obesity, to increase the insulin secretion via pancreatic beta cells regeneration and to deterimine anti-sweet activity on tongue [6].…”

Section: Introductionmentioning

confidence: 99%

HPTLC/HPLC and gravimetric methodology for the identification and quantification of gymnemic acid fromGymnema sylvestremethanolic extracts

Ahmed¹,

Rao²,

Rao³

et al. 2013

Acta Chromatographica

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Summary. Gymnemic acid (GA), a well known anti-diabetic compound has been detected in methanol extracts of intact leaves and in vitro callus cultures derived from leaf explants of Gymnema sylvestre. Callus biomass was developed in MS medium with optimum plant growth regulators (OPGRs) of 2,4-D (1.5 mg L −1 ) + KN (0.5 mg L −1 ) under abiotic stress conditions at 45 days determined by growth curve analysis. GA detection and quantification were carried out using thin-layer chromatography (TLC), highperformance thin-layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), and gravimetric techniques. GA detection peak area and their absorption spectra were evaluated through HPTLC and HPLC with the standard GA. Quantification of GA had showed the linearity, accuracy, robustness and precision by HPLC. GA content was significantly higher in gravimetric method than HPLC. All these methods were found to be simple, accurate, selective and rapid and could be successfully applied for the determination of GA. It could have potential as a pharmaceutical drug for Type 1 diabetes mellitus (IDDM) and obesity.

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Possible regeneration of the islets of langerhans in streptozotocin-diabetic rats given gymnema sylvestre leaf extracts

Cited by 219 publications

References 10 publications

Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes

Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes

Evaluation of Hypoglycemic Property of Gurmar (Gymnema Sylvestre) Leaves Methanolic Extract (GSLME) in Streptozocin (STZ) induced Diabetic Albino Rats

HPTLC/HPLC and gravimetric methodology for the identification and quantification of gymnemic acid fromGymnema sylvestremethanolic extracts

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