Possible relationship between tympanosclerosis and atherosclerosis

Pirodda, Antonio; Ferri, Gian Gaetano; Bruzzi, Caterina; Marini, Massimiliano; Faggioli, Gianluca

doi:10.1080/00016480310014822

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…Inducible nitric oxide synthase is also reported to participate in tympanosclerosis formation 9 19 , 23 Nitric oxide is thought to be secreted (dependent on cytokines) and to reduce osteoclast activity and osteoblast secretion, leading to tympanosclerosis formation 24 …”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

et al. 2016

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“…In addition, their control subjects were younger than atherosclerotic patients. Ferri et al investigated the possible relationship between tympanosclerosis and atherosclerosis in 84 patients with significant carotid disease and presented in two publications (9,10). They found that patients with carotid atherosclerosis had higher incidence of tympanosclerosis compared to the controls (38 vs 13%, p=0.05; 36 vs 12%, p=0.005).…”

Section: Discussionmentioning

confidence: 99%

“…There are some reports about the possible relationship between development of tympanosclerosis and atherosclerosis (8)(9)(10). Therefore, in the current study, we aimed a cross-sectional study to examine the relation between tympanosclerosis and angiographic extent and severity of atherosclerosis in patients referred for elective coronary angiography.…”

Section: Introductionmentioning

confidence: 99%

Is there any relation between coronary atherosclerosis and tympanosclerosis?

Cicek¹,

Vayısoğlu²,

Görür³

et al. 2010

Anadolu Kardiyol Derg

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Objective: Atherosclerosis is a chronic inflammatory disease of medium and large-sized arteries. Tympanosclerosis is the hyalinization and calcification of the connective tissue in the middle ear, including the tympanic membrane. The etiology and pathogenesis of tympanosclerosis are still controversial. There are some reports about the possible relationship between development of tympanosclerosis and atherosclerosis. Therefore, we aimed a cross-sectional study to investigate relationship between tympanosclerosis and atherosclerosis in patients referred for coronary angiography. Methods: The study population consisted of 203 consecutive patients (145 men, mean age 59±11years) who underwent coronary angiography. Otoscopic examination was performed in all patients. All angiographies were examined to calculate coronary artery vessel stenosis and extent scores. Mann-Whitney U test was used to compare the angiographic scores with existence of tympanosclerosis. Results: Among the 203 patients, 35 (17%) patients had angiographically normal coronary arteries without any atheroma plaque and 168 (83%) had coronary atherosclerosis. In the otoscopic examination, tympanosclerosis was found in 14 patients (6.9%). No significant differences in distribution of clinical atherosclerotic risk factors (age, gender, body mass index, hypertension, diabetes mellitus, cigarette smoking and cholesterol levels) were found between groups with and without tympanosclerosis. Tympanosclerosis was found in 4 patients with normal coronary arteries (11.4%). In the group of coronary atherosclerosis, 10 patients have tympanosclerosis (5.9%). In addition, there was no statistically significant association of coronary artery vessel, stenosis or extent scores of atherosclerosis with tympanosclerosis (p>0.05). Conclusions: We could not find any association between tympanosclerosis and angiographic extent and severity of atherosclerosis, contrary to other studies. More studies are needed to understand etiological mechanisms and association between them. (Anadolu Kardiyol Derg 2010; 10: 121-5) Key words: Atherosclerosis, tympanosclerosis, coronary angiography, angiographic scoring ÖZET Amaç: Ateroskleroz orta ve büyük arterlerin kronik inflamatuvar bir hastalığıdır. Timpanoskleroz, timpanik zarı da içine alacak şekilde orta kulak bağ dokusunda hyalinizasyon ve kalsifikasyon oluşmasıdır. Timpanosklerozun etiyoloji ve patogenezi hala tartışmalıdır. Ateroskleroz ve timpanoskleroz gelişimi arasında olası ilişkiye yönelik bazı çalışmalar mevcuttur. Biz bu kesitsel çalışmada, koroner anjiyografiye gönderilen hastalarda timpanoskleroz ve ateroskleroz arasındaki ilişkiyi araştırmayı amaçladık. Yöntemler: Koroner anjiyografiye gönderilen 203 ardışık hasta (145 erkek, yaş 59±11 yıl) çalışmaya alındı. Bütün hastalara otoskopik muayene yapıldı. Koroner anjiyografilerde damar, darlık ve yaygınlık skorları hesaplandı. Timpanoskleroz varlığı ile anjiyografik skorları karşılaştırmak için Mann-Whitney U testi kullanıldı. Bulgular: İki yüz üç hastadan, 35 (%17) ha...

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“…atherosclerosis and osteoarthritis) matrix metalloproteinase activity increases 3 . Pathogenetic similarities between atherosclerosis and tympanosclerosis have been described; the pathogenesis of both diseases appears to be related to matrix metalloproteinases 4 . We have previously described a relationship between tympanosclerosis and matrix metalloproteinase 2 (also known as collagenase A), matrix metalloproteinase 9 (also known as collagenase B) and tissue matrix metalloproteinase inhibitor 1.…”

Section: Introductionmentioning

confidence: 98%