The neutron activation technique is utilized to determine activation cross-section values for neutron-induced reactions on Lu, Tb, Dy, Er and Yb isotopes with application of in-home designed and manufactured neutron generator NG-300 and AMANDE facility within 3.5÷14.7 MeV energy range of incident neutrons. Observation of the dineutron in the output channel of nuclear reaction on Tb is discussed. The cross-section estimate for the reaction with a dineutron escape for 6.85 MeV equals 75 ± 30 mb and is presented for the first time.