Possible role of 2-phenylethylamine in the modulation of extrapyramidal function

Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde

“…Phenylethylamine or β-phenethylamine, is an organic compound and a natural mono amine alkaloid, a trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects [1]. Phenylethylamine functions as a neuromodulator or neurotransmitter in the mammalian central nervous system [2]. The chemistry of the carbon-nitrogen double bond plays a vital role in progresses of chemistry science.…”

A New Putative Neuroregulator of the Extrapyramidal System

“…The potential impor tance of demonstrating not only a regulatory role, but also brain localization of a neurotrans mitter to the EPS, is best illustrated by the studies that have shown a brain deficit of dopa mine to be found in the EPS of parkinsonian patients (13), and that replenishing brain dopa mine by the administration of L-dihydroxyphenylalanine (¿-dopa) produces clinical im provement in Parkinson's disease (3). With this in mind, and the facts that a new putative neurotransmitter, 2-phenylethylamine (PEA), is most highly concentrated in the EPS and limbic system of rat brain ( 12) and human brain (8), preliminary evidence that PEA urinary excre tion is decreased among nonmedicated patients with Parkinson's disease (21), and that PEA reverses the reserpine model of parkinsonism in animals (19), would all suggest a regulatory role for PEA in the EPS. To further study this possible role, we have reinvestigated the effect of PEA upon the reserpine-induced model for par kinsonism and its ability to produce stereotypy.…”