Possible role of calcium in phospholipid synthesis of Microsporum gypseum

Giri, Shailendra; Mago, Nandini; Bindra, Anu; Khuller, G. K.

doi:10.1016/0005-2760(94)90062-0

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Calcium grown calls exhibited a significant increase (1.6 fold) in total as well as individual phospholipids which was further supported by increased incorporation of labelled acetate/phosphate into total phospholipids and increased activity of key phospholipid biosynthetic enzymes (glycerol kinase and glycerol-3-PO acyltransferase) in calcium grown cetts (42,4~). An increase in fatty acid synthesis was observed in calcium grown cells, which suggests an increase in phospholipids due to increased synthesis of fatty acids, which ultimately enhanced the activity of glycerol-3-PO4 acyltransferase (37).…”

Section: Regulation Of Phospholipids By Calc~uml Calmodulinmentioning

confidence: 93%

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Dermatophyte lipids—Composition and regulation of phospholipids

Khuller

Sharma

Deo

2000

Indian J Clin Biochem

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This review presents the extensive work carried out on lipid components of dermatophytes, their biosynthesis, turnover and regulation. It emerges from the work done so far that the pathways of lipid biosynthesis/degradation and the lipid composition in dermatophytes are similar to those in yeasts and other fungi. Second messengers (Ca 2 § cAMP) were demonstrated to have a regulatory role in phospholipid metabolism and they mainly act by stimulating Ca2*/CaM or cAMP dependent protein kinase(s). Both these kinases were purified and characterized in Microsporum gypseum. Further work is being carried out to elucidate the molecular mechanism of regulation of phospholipid metabolism by these second messengers.

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Section: Regulation Of Phospholipids By Calc~uml Calmodulinmentioning

confidence: 93%

“…Both the pathways are interrelated and act synergistically to regulate cellular functions (35). Both cAMP and calcium have been shown to regulate phospholipid synthesis in Microsporum gypseum, a dermatophyte (36,37).…”

Section: Role Of Second Messengers In the Regulation Of Phospholipid mentioning

confidence: 99%