Possible role of mast cells in the mechanism of action of intrauterine contraceptive devices

Tursi, A.; Mastrorilli, Angela; Ribatti, Doménico; Loiudice, L; Contino, R.; Claudatus, John

doi:10.1016/s0002-9378(84)90446-0

Cited by 14 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1979). Increased numbers of mast cells have also been reported from uterine smears of women using an IUCD (Tursi et al 1984).…”

Section: Discussionmentioning

confidence: 87%

“…However, this observation agrees well with the previously reported abundance of mast cells in the uterine wall of women using an IUCD (Sheppard & Bonnar 1979) and of hamsters with an implanted IUCD (Moore et uf. Increased numbers of mast cells have also been reported from uterine smears of women using an IUCD (Tursi et al 1984). Increased numbers of mast cells have also been reported from uterine smears of women using an IUCD (Tursi et al 1984).…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Mast cells in the tubal wall in women using an intrauterine contraceptive device

Sandvei

Wollen

Flood

et al. 1986

BJOG

View full text Add to dashboard Cite

The number of mast cells in the tubal wall of 33 healthy nonpregnant women, 17 of whom had an intrauterine contraceptive device (IUCD), was investigated. Light microscopy showed that both the muscularis externa and the lamina propria of the tubal wall contained more mast cells in the 17 IUCD users than in the 16 non-users (control group). In both patient groups the mast cell concentration was higher in the muscularis externa than in the lamina propria. Most mast cells of the muscularis externa were more closely related t o smooth muscle cells than to blood vessels. T h e increased number of mast cells in IUCD users may b e a factor in the pathogenesis of pelvic inflammatory disease and the ectopic pregnancies that occur in IUCD users.

show abstract

“…1979). Increased numbers of mast cells have also been reported from uterine smears of women using an IUCD (Tursi et al 1984).…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 91%

Mast cells in the tubal wall in women using an intrauterine contraceptive device

Sandvei

Wollen

Flood

et al. 1986

BJOG

View full text Add to dashboard Cite

show abstract

“…Recently the functional roles of these latter "inflammatory" cells in remodeling processes during the normal menstrual cycle have been receiving attention [3]. The MC in particular has been the subject of several histological reports [4][5][6][7][8][9], and MC numbers have been related to various clinical conditions [10][11][12]. The MC is now considered to play a pivotal role in a variety of biological responses including angiogenesis, fibrosis, wound healing, inflammation, and tissue remodeling [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Mast Cell and Eosinophil Distribution and Activation in Human Endometrium throughout the Menstrual Cycle1

Jeziorska¹,

Salamonsen

Woolley³

1995

Biology of Reproduction

139

View full text Add to dashboard Cite

Tryptase and chymase immunolocalization techniques have been used to examine the distribution, activation, and tryptase/chymase phenotype of mast cells (MCs) in 107 endometrial specimens that represented every day of the human menstrual cycle. MCs were identified in the endometrium in all stages of the menstrual cycle; similar MC numbers were observed for the functionalis, basalis, and muscularis. Extensive MC activation/degranulation, as judged by extracellular tryptase, was a common feature of the functionalis in specimens sampled just prior to and during menstruation. MC activation was also prominent in the functionalis at times coincident with recognized stromal edema. MCs of the functionalis did not contain chymase; all stained for tryptase and represent the MCT phenotype. By contrast, the basalis and muscularis showed a proportion of MCs containing both tryptase and chymase, MCTC. One important function for extracellular MC tryptase and chymase is their ability to activate precursor forms of the matrix metalloproteinases, enzymes recognized as instrumental in stromal degradation. Quantitative analysis of MC numbers, expressed relative to stromal cell numbers/mm2, indicated no major changes during the menstrual cycle, although changes in MC morphology, granule content, and activation/degranulation were recognized for specific stages. Eosinophils, detected with monoclonal antibodies EG1 and EG2, were absent from extravascular sites between Days 5 and 26 but showed local accumulations just prior to and during menstruation. Since MCs and eosinophils between them contain a variety of potent mediators, it seems likely that both cell types assume important functional roles in relation to tissue and vascular remodeling associated with endometrial physiology.

show abstract

“…A contraceptive intra-uterine device (IUD) is not just an inert device seated inactively in the uterus. IUDs have been reported to induce profound endometrial changes, including sterile inflammatory changes (Sheppard, 1987;Sagiroglu and Sagiroglu, 1970), an increased number of mast cells (Tursi et al, 1984;Kobayashi et al, 1983), superficial loss of surface epithelium (Sheppard and Bonnar, 1980;El-Badrawi et al, 1981), reduction of ciliated cells with impairment of the secretory activity in the epithelium contiguous to the device (Gonzalez-Angulo et al, 1973), and alterations in endometrial response to estrogen and progesterone (Tamaya et al, 1976;Ghosh et al, 1975;Ghosh and Roy, 1976;Kontula et al, 1974).…”

mentioning

confidence: 99%

Intra‐uterine contraception and the risk of endometrial cancer

Castellsagué

Dubrow

1993

Intl Journal of Cancer

View full text Add to dashboard Cite

Despite the increasing world-wide popularity of contraceptive intra-uterine devices (IUDs), their potential long-term effects on the risk of developing endometrial carcinoma have been poorly studied. This paper reports on the relationship between intra-uterine contraception and endometrial cancer by analyzing epidemiological data from a large, multicenter, population-based, case-control study of epithelial endometrial cancer. Cases were 437 women, 20 to 54 years of age, with histologically confirmed epithelial endometrial cancer ascertained through 6 population-based cancer registries in the United States. Controls were 3200 women selected at random from the populations of these areas. The age- and parity-adjusted odds ratio (OR) for the association between ever having used intra-uterine contraception and endometrial cancer was 0.51 (95% confidence interval (CI) 0.3-0.8). Although the protective effect increased with duration of use, a dose-response relationship among users was not statistically demonstrable. The association did not vary significantly with age at first or last IUD use or with time elapsed since first or last IUD use. Years of education significantly modified the effect of intra-uterine contraception. Thus, intra-uterine contraception appeared to be strongly protective for women with at least 13 years of education (OR = 0.29, 95% CI, 0.15-0.6). It is proposed that intra-uterine contraception exerts its protective effect through local structural and biochemical changes in the endometrium that may alter endometrial sensitivity and response to circulating estrogen and progesterone.

show abstract

Possible role of mast cells in the mechanism of action of intrauterine contraceptive devices

Cited by 14 publications

References 3 publications

Mast cells in the tubal wall in women using an intrauterine contraceptive device

Mast cells in the tubal wall in women using an intrauterine contraceptive device

Mast Cell and Eosinophil Distribution and Activation in Human Endometrium throughout the Menstrual Cycle1

Intra‐uterine contraception and the risk of endometrial cancer

Contact Info

Product

Resources

About