Possible Role of Mycoplasma Fermentans in Pathogenesis of Rheumatoid Arthritis

Williams, M. H.; Brostoff, Jonathan; Roitt, Ivan M.

doi:10.1016/s0140-6736(70)91328-0

Cited by 139 publications

(62 citation statements)

References 15 publications

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“…joints with rheumatoid arthritis (RA) (37) and detected in joints with RA by PCR (34). M. fermentans can induce experimental arthritis in animals (24).…”

Section: Discussionmentioning

confidence: 99%

Mycoplasmal Lipoproteins Induce Toll‐Like Receptor 2‐ and Caspases‐Mediated Cell Death in Lymphocytes and Monocytes

Into

Nodasaka

Hasebe

et al. 2002

Microbiology and Immunology

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Lipoproteins of Mycoplasma salivarium and Mycoplasma fermentans preferentially induced necrotic cell death in lymphocytic cell lines, MOLT‐4 and Raji, and in one monocytic cell line, THP‐1, whereas they preferentially induced apoptotic cell death in another monocytic cell line, HL‐60. These findings were also supported by ultrastructural observations by the use of scanning and transmission electron microscopes and by agarose gel electrophoresis of the genomic DNA. The lipoproteins activated caspase‐3 in both MOLT‐4 and HL‐60 cells, which was assessed by the cleavage of the synthetic substrate DEVD‐pNA and the endogenous substrate poly(ADP‐ribose) polymerase. The cytotoxicity to MOLT‐4 and HL‐60 cells was inhibited by various caspase inhibitors, Ac‐DMQD‐CHO, Ac‐IETD‐CHO, and Z‐VAD‐FMK. The cytotoxicity was also partially suppressed by the monoclonal antibody to Toll‐like receptor 2. Thus this study demonstrated that mycoplasmal lipoproteins induce caspases‐dependent necrotic and apoptotic cell death in lymphocytes and monocytes/macrophages, which is partially induced by TLR2‐mediated signaling.

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“…joints with rheumatoid arthritis (RA) (37) and detected in joints with RA by PCR (34). M. fermentans can induce experimental arthritis in animals (24).…”

Section: Discussionmentioning

confidence: 99%

Mycoplasmal Lipoproteins Induce Toll‐Like Receptor 2‐ and Caspases‐Mediated Cell Death in Lymphocytes and Monocytes

Into

Nodasaka

Hasebe

et al. 2002

Microbiology and Immunology

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“…M. fermentans is frequently isolated from the synovial fluid of rheumatoid arthritis patients (27,29,34,35) and exhibits agglutinating activity toward erythrocytes. These observations suggest the possibility that M. fermentans has a role in the pathogenesis of rheumatoid arthritis.…”

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confidence: 99%

Monoclonal Antibody against Mycoplasma fermentans‐Specific Aminoglycoglycerolipid

Matsuda¹,

Ichinose

et al. 2000

Microbiology and Immunology

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Previously, we reported that Mycoplasma fermentans has specific antigens (phosphocholinecontaining glycoglycerolipids: GGPL-I and GGPL-III) and discussed the possibility of their pathogenic role. In this paper, we report the characterization of a monoclonal antibody (MF-III-1) specific to GGPL-III (phosphocholine-containing aminoglycoglycerolipid) using methods of electron microscopy, immunofluorescence cell surface staining, laser scanning microscopy, immunoelectron microscopy, and thin-layer chromatography immunostaining. The MF-III-1 antibody specifically recognized M. fermentans attached to the surface of HTLV-I-infected human helper T-cells, and it did not cross-react with other lipids nor with human T-cell antigens. Since MF-III-1 distinguishes GGPL-III from GGPL-I, the binding site may include a serinol (2-amino-1,3-propanediol) residue of GGPL-III. MF-III-1 is useful for the in vitro study of M. fermentans, and may also be useful as a tool for the study of the involvement of M. fermentans in human diseases.

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“…Although M. fermentans has been recovered from the urogenital and respiratory tract, bone marrow, and joints of patients, [59][60][61][62] little consideration was given to the possibility that this organism was a human pathogen until the description of an organism tentatively named M. incognitus. It was originally reported in patients with acquired immunodeficiency syndrome (AIDS) and was later found in non-AIDS patients.…”

Section: Discussionmentioning

confidence: 99%

No serologic evidence of an association found between Gulf War service and Mycoplasma fermentans infection.

Gray¹,

Kaiser²,

Hawksworth³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. Occult occupational infection with Mycoplasma fermentans has been proposed as a cause for illness among Persian Gulf War veterans. Symptom data and sera from a 1994-1995 cross-sectional survey of Navy Seabees were used to select symptomatic and asymptomatic Gulf War veterans and nondeployed veterans to evaluate this hypothesis. Survey sera from 96 Seabees were matched to prewar (before September 1990) archived sera. Immunoblot serologic analyses were performed for M. fermentans in a controlled, blinded fashion. Both Gulf War veterans and nondeployed veterans had prewar and postwar serologic evidence of M. fermentans infection consistent with natural infection data. Among study subjects collectively, and stratified by Gulf War service, none of the immunoblot banding profiles (prewar or postwar) or their changes over time were associated with postwar symptoms. These serologic data do not support the hypothesis that Gulf War veterans have experienced Gulf War-related morbidity from M. fermentans infection.

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Possible Role of Mycoplasma Fermentans in Pathogenesis of Rheumatoid Arthritis

Cited by 139 publications

References 15 publications

Mycoplasmal Lipoproteins Induce Toll‐Like Receptor 2‐ and Caspases‐Mediated Cell Death in Lymphocytes and Monocytes

Mycoplasmal Lipoproteins Induce Toll‐Like Receptor 2‐ and Caspases‐Mediated Cell Death in Lymphocytes and Monocytes

Monoclonal Antibody against Mycoplasma fermentans‐Specific Aminoglycoglycerolipid

No serologic evidence of an association found between Gulf War service and Mycoplasma fermentans infection.

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