Possible role of Omega-3 on the pancreas of streptozotocin-induced diabetes in adult albino rats

Habib, Eman K.

doi:10.1097/01.ehx.0000431956.27366.8f

Cited by 5 publications

(1 citation statement)

References 31 publications

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“…In fact, our research finding was in line with Bellenger et al (2011) and Soltan (2012) who reported that an omega-3 fatty acids enrichment diet prevents necrotic changes and atrophy of the pancreatic islet. Indeed, omega-3 fatty acids provoke beta-cell regeneration and protect the pancreas from apoptosis ( Habib, 2013 ; Li et al ., 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Titisari,

Fauzi,

Razak

et al. 2023

Open Vet J

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Background: Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial. Aim: To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes. Methods: Diabetic rats model (n=30) were divided into 5 groups and received; 1) NS injection+NS oral (NC); 2) NS injection+3g/kg fish oil (FC); 3) STZ injection+NS oral (DC); 4) STZ injection+1g/kg fish oil (DFO1) and 5) STZ injection+3g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin ELISA assay; meanwhile, the determination of insulin sensitivity was calculated by HOMA-IR and HOMA-B. A histological study was conducted on pancreas tissue using H & E staining. Results: Fish oil supplementation reduced hyperglycemia and ameliorated HOMA IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than diabetic control animals (DC). This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ. Conclusion: Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy.

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Section: Discussionmentioning

confidence: 99%

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Titisari,

Fauzi,

Razak

et al. 2023

Open Vet J

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Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia

Chandravanshi

Bhonde

2016

European Journal of Pharmacology

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Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes

Wahba

Shaban

Kattaia

et al. 2016

Ultrastructural Pathology

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Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations. ZnO NPs effectively reversed diabetes-induced pancreatic injury, as evidenced by the structural and ultrastructural improvement and confirmed by biochemical normalization of blood glucose and serum insulin.

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Possible role of Omega-3 on the pancreas of streptozotocin-induced diabetes in adult albino rats

Cited by 5 publications

References 31 publications

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia

Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes

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