Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer

Song, Xuejing; Traub, Benno; Shi, Jingwei; Kornmann, Marko

doi:10.3390/ijms22020727

Cited by 46 publications

(26 citation statements)

References 179 publications

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“…IL-13 is an immunomodulatory factor that can regulate inflammation and immune response ( 19 ). IL-13 is produced by a variety of immune cells, such as CD4-T cells, basophils, eosinophils and NK cells, which are essential for the induction and persistence of type 2 immune responses.…”

Section: Discussionmentioning

confidence: 99%

Identification of Molecular Subtypes and a Prognostic Signature Based on Inflammation-Related Genes in Colon Adenocarcinoma

Qiu

Shi

et al. 2021

Front. Immunol.

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Both tumour-infiltrating immune cells and inflammation-related genes that can mediate immune infiltration contribute to the initiation and prognosis of patients with colon cancer. In this study, we developed a method to predict the survival outcomes among colon cancer patients and direct immunotherapy and chemotherapy. We obtained patient data from The Cancer Genome Atlas (TCGA) and captured inflammation-related genes from the GeneCards database. The package “ConsensusClusterPlus” was used to generate molecular subtypes based on inflammation-related genes obtained by differential expression analysis and univariate Cox analysis. A prognostic signature including four genes (PLCG2, TIMP1, BDNF and IL13) was also constructed and was an independent prognostic factor. Cluster 2 and higher risk scores meant worse overall survival and higher expression of human leukocyte antigen and immune checkpoints. Immune cell infiltration calculated by the estimate, CIBERSORT, TIMER, ssGSEA algorithms, tumour immune dysfunction and exclusion (TIDE), and tumour stemness indices (TSIs) were also compared on the basis of inflammation-related molecular subtypes and the risk signature. In addition, analyses of stratification, somatic mutation, nomogram construction, chemotherapeutic response prediction and small-molecule drug prediction were performed based on the risk signature. We finally used qRT–PCR to detect the expression levels of four genes in colon cancer cell lines and obtained results consistent with the prediction. Our findings demonstrated a four-gene prognostic signature that could be useful for prognostication in colon cancer patients and designing personalized treatments, which could provide new versions of personalized management for these patients.

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Section: Discussionmentioning

confidence: 99%

Identification of Molecular Subtypes and a Prognostic Signature Based on Inflammation-Related Genes in Colon Adenocarcinoma

Qiu

Shi

et al. 2021

Front. Immunol.

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“…In addition, IL-13 appears to play its own distinct role in cancer cells through binding to IL-13Rα2 with high affinity [77] and mediating invasion and metastasis via IL-13Rα2, ERK/activator protein 1 (AP-1) signaling, and matrix metalloproteinases (MMPs) pathways [78]. Besides, Song summarized the structure of IL-4R, IL-13R, and the downstream complex web where IL-4/IL-13 initiated signal transduction through three types of IL-4 receptors and three types of IL-13 receptors [79].…”

Section: Il-4 and Il-13 Cytokines And Their Receptorsmentioning

confidence: 99%

Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer

Shi

Song

Traub

et al. 2021

IJMS

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Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies. It is now generally accepted that IL-4 and IL-13 can exert effects on epithelial tumor cells through corresponding receptors. Type II IL-4 receptor (IL-4Rα/IL-13Rα1), predominantly expressed in non-hematopoietic cells, is identified to be the main target for both IL-4 and IL-13 in tumors. Moreover, IL-13 can also signal by binding to the IL-13Rα2 receptor. Structural similarity due to the use of the same receptor complex generated in response to IL-4/IL-13 results in overlapping but also distinct signaling pathways and functions. The aim of this review was to summarize knowledge about IL-4 and IL-13 and their receptors in pancreatic cancer in order understand the implication of IL-4 and IL-13 and their receptors for pancreatic tumorigenesis and progression and for developing possible new diagnostic and therapeutic targets.

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“…While IL-13 can also connect to three separate receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After binding to its receptor, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in colorectal and gastric cancers ( Song et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis

et al. 2022

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Patients with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, are at higher risk to develop colorectal cancer (CRC). However, the underlying mechanisms of this predisposition remain elusive. We performed in-depth comparative computational analyses to gain new insights, including weighted gene co-expression network analysis (WGCNA) and gene ontology and pathway enrichment analyses, using gene expression datasets from IBD and CRC patients. When individually comparing IBD and CRC to normal control samples, we identified clusters of highly correlated genes, differentially expressed genes, and module-trait associations specific for each disease. When comparing IBD to CRC, we identified common hub genes and commonly enriched pathways. Most notably, IBD and CRC share significantly increased expression of five genes (MMP10, LCN2, REG1A, REG3A, and DUOX2), enriched inflammatory and neutrophil activation pathways and, most notably, highly significant enrichment of IL-4 and IL-13 signaling. Thus, our work expands our knowledge about the intricate relationship between IBD and CRC development and provides new rationales for developing novel therapeutic strategies.

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Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer

Cited by 46 publications

References 179 publications

Identification of Molecular Subtypes and a Prognostic Signature Based on Inflammation-Related Genes in Colon Adenocarcinoma

Identification of Molecular Subtypes and a Prognostic Signature Based on Inflammation-Related Genes in Colon Adenocarcinoma

Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer

Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis

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