Post-awakening salivary alpha-amylase as modulator of treatment response in patients with burnout and major depression

Pallich, Gianandrea; Fischer, Susanne; Marca, Roberto La; Holtforth, Martin Grosse; Hochstrasser, Barbara

doi:10.1016/j.jpsychires.2022.07.045

Cited by 3 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All data were normalized to standard curves prior to statistical analysis. To reduce positive skew, cortisol data were subject to log transformation and sAA data were subject to square root transformation ( 39 , 40 ).…”

Section: Methodsmentioning

confidence: 99%

Cross-sectional analysis reveals COVID-19 pandemic community lockdown was linked to dysregulated cortisol and salivary alpha amylase in children

Lloyd,

Gabard-Durnam,

Beaudry

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

The COVID-19 pandemic altered everyday life starting in March 2020. These alterations extended to the lives of children as their normal routines were disrupted by community lockdowns, online learning, limited in-person social contact, increased screen time, and reduced physical activity. Considerable research has investigated the physical health impact of COVID-19 infection, but far fewer studies have investigated the physiological impact of stressful pandemic-related changes to daily life, especially in children. The purpose of this study was to leverage an ongoing clinical trial to investigate physiological consequences associated with chronic stress of pandemic community lockdown on children. As a part of the clinical trial, children provided saliva samples. Saliva samples were analyzed for cortisol and salivary alpha amylase (sAA) content. This secondary cross-sectional analysis included 94 preadolescent children located within the Greater Boston, Massachusetts community. Children participated in the study either before, during, or following the pandemic community lockdown to form three groups for comparison. In response to chronic stress caused by the pandemic community lockdown, participants demonstrated dysregulation of fast-acting catecholamine response of the locus-coeruleus-norepinephrine system and slower-acting glucocorticoid response, resulting in an asymmetrical relationship of hypocortisolism (M = 0.78 ± 0.19 μg/mL, p < 0.001) paired with higher sAA (M = 12.73 ± 4.06 U/mL, p = 0.01). Results suggest that the abrupt COVID-19 disruption to daily life, including the stressful experience of community lockdown, had physiological effects on typically developing children. Further research is required to investigate mental health outcomes of children following the chronic stress of the pandemic community lockdown.

show abstract

Section: Methodsmentioning

confidence: 99%

Cross-sectional analysis reveals COVID-19 pandemic community lockdown was linked to dysregulated cortisol and salivary alpha amylase in children

Lloyd,

Gabard-Durnam,

Beaudry

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…El cortisol también impacta en los resultados de tratamientos con psicoterapia y antidepresivos. Los altos niveles del mismo significan una peor respuesta al tratamiento, lo cual indica que mientras mayor sea la alteración del eje antes del tratamiento, mayor será la complicación para que el tratamiento sea efectivo (Pallich et al, 2022).…”

Section: Apoyo Socialunclassified

Síndrome de burnout, depresión e inteligencia emocional en el personal de salud de un hospital de la ciudad de Durán (Ecuador)

Jurado¹

View full text Add to dashboard Cite

Background: Burnout syndrome and depression constitute a concern to healthcare workers, particularly for those who care for patients in the emergency room and intensive care units, due to the physical and mental health wear. Emotional intelligence provides skills to help health professionals adapt to new situations in positive ways. This investigation will evaluate the association between burnout syndrome, depression, emotional intelligence and health behaviors in healthcare workers. Methodology: This is a correlational crosssectional cohort study with a population made up of healthcare workers from IESS Duran hospital, Ecuador, with a sample of 202 employees. Several surveys are used to determine demographic data, as well as clinical data such as anthropometric measurements and vital signs. Other surveys are also used: The Maslach Burnout Inventory (MBI), the Trait Meta-Mood Scale (TMMS-24) and the PHQ-9 depression screening questionnaire.Results: 71.2% of the participants had significant scores in at least one MBI subscale. 10.6% show high emotional exhaustion, 23.7% have high depersonalization and 50.5% have low personal fulfillment. 12.4% demonstrated burnout traits and 11.4% had moderate to severe levels of depression, indicating that there is positive associat ion between burnout and depression. On the other hand, emotional intelligence appears negatively associated with burnout and depression. The regression analysis indicates that high depression scores are explained by the combined effect of excessive emotional fatigue, high burnout, and low emotional repair. Conclusion: Healthcare workers are exposed to high levels of responsibility, suffering in patients and death, which happens more particularly when a health crisis occurs. This leads to a higher risk of burnout and depression. It is necessary to implement individual and organizational protection strategies that enhance emotional intelligence, as a way to avoid these psychosocial risks.

show abstract

Severity of depressive symptoms moderates the sympathoinhibitory effect of local skin warming following exposure to a social stressor

Tyler,

Wright,

Beaton

et al. 2024

Psychoneuroendocrinology

View full text Add to dashboard Cite

Post-awakening salivary alpha-amylase as modulator of treatment response in patients with burnout and major depression

Cited by 3 publications

References 32 publications

Cross-sectional analysis reveals COVID-19 pandemic community lockdown was linked to dysregulated cortisol and salivary alpha amylase in children

Cross-sectional analysis reveals COVID-19 pandemic community lockdown was linked to dysregulated cortisol and salivary alpha amylase in children

Síndrome de burnout, depresión e inteligencia emocional en el personal de salud de un hospital de la ciudad de Durán (Ecuador)

Severity of depressive symptoms moderates the sympathoinhibitory effect of local skin warming following exposure to a social stressor

Contact Info

Product

Resources

About