Post-Coronary Artery Bypass Graft Complications; Potential Causes and Risk Factors

Marzoog, Basheer Abdullah; Karpunkin, O. A.; Tremasov, Maxim Nikolaevich; Kostin, S. V.

doi:10.1101/2022.12.29.22284005

Cited by 6 publications

(10 citation statements)

References 38 publications

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“…Post-MI changes include early and late pathophysiological changes, early post-MI complications include ventricular rupture, aneurism, arrythmia, sudden cardiac arrest and death [11][12][13] . However, the late changes include pericarditis, pneumonitis, pleuritis, and post infarction cardiosclerosis and dyskinesia [14,15] . Such manifestations are associated with some laboratory and instrumental changes.…”

Section: Discussionmentioning

confidence: 99%

“…Lifestyle changes have a huge impact on the overall health of the cardiovascular system [3,4]. Unfortunately, sedentary lifestyle is seen in majority of myocardial infarction, which is associated with development of several predisposition factors for cardiovascular events such as dyslipidaemia, insulin resistance, and central obesity or visceral obesity [5][6][7][8][9]. Collectively, these early signs of disturbance of cardiovascular homeostasis are ignored to provoke the progression of dyslipidaemia and insulin resistance to reach enough levels to induce the emergence of cardiovascular events such as MI [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…The role of these changes is unclear in determining the prognosis of patients with MI and the potential risk of developing complications such as renal failure. In the current retrospective analysis, we covered the potential role of these systemic and the regularly checked cardiac markers in the prognosis determination and prognosis of the patients [5, 8, 20–23, 9, 13–19].…”

Section: Introductionmentioning

confidence: 99%

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Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Marzoog

Bloshkina

Gromova

et al. 2023

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Background: Cardiovascular events remain one of the frequently reported causes of death globally. Aims: Assess the early laboratory and instrumental changes in systemic manner. Objectives: Patients with fresh myocardial infarction that has been occurred in less than 30 days before hospitalization in the rehabilitation hospital. Materials and methods: A single large scale retrospective cohort sectional study for patient with fresh myocardial infarction for the period of 2014-2019, data collected from Mordovia Rehabilitation Hospital. The study involved 154 patients and analyzed 76 parameters for each patient. The t-test, Pearson correlation coefficient, and ROC test has been used. For statistical analysis used Statistica program. Results: The sample included 154 patients with history of fresh myocardial infarction. Of 154. 51(33.11%) female and 103 (66.88 %) males. chronic heart failure (CHF), which is seen in 42 (27.27273 %) patients, 101 (65.58442 %) did not have a CHF, and 11 (7.14286 %) missing data. Diabetes mellitus (DM) has been observed in 28 (18.18182 %), 118 (76.62338 %) without DM, Hypertension has been seen in 118 (76.62338 %), 28 (18.18182%) did not have hypertension, chronic kidney disease (CKD) has been seen in 11 (7.14%) patients, 131 (85.06494 %) did not have CKD, Chronic obstructive pulmonary disease (COPD) existed in 14 (9.09091%), 132 (85.71429 %) did not have COPD. Post myocardial infarction (MI) CHF has been seen in 108 (70.12987%), 42 (27.27273 %) did not have CHF. Post MI arrythmia seen in 50 (32.47%) patients, 99 (64.28571%) did not have arrythmia. Early post MI complication such as aneurysm has been seen in 12 (7.79221%), 138 (89.61039 %) did not have aneurysm, Dressler syndrome; pericarditis has been seen in 4 (2.59740%) patients, pneumonitis seen in 1 (0.64935%) patient, and pleuritis have not been seen. Conclusions: Systemic manifestations include kidney function impairment or development of new kidney disease. Of these changes include increase in the aorta basement diameter, increase in the right ventricle wall thickness, decrease in the level of serum red blood cell, serum potassium level, and serum calcium level, with increase in the serum myoglobulin. Others: Females are more frequently affected with post MI urinary tract infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Marzoog

Bloshkina

Gromova

et al. 2023

Preprint

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“…However, the potential pathophysiological pathway is multifactorial and involves autophagy dysfunction, upregulated sympathetic tone, mitochondrial dysfunction, inflammation, abnormal atrial conduction, and systemic inflammatory response indicated by elevated C-reactive protein and leukocytes [22–31]. Some studies showed that on-pump CABG surgery has higher risk of atrial fibrillation than off-pump [32–37].…”

Section: Discussionmentioning

confidence: 99%

Incidence Rate of Post Coronary Artery Shunt Complications; Age Dependent!

Marzoog

2022

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Background: Post-coronary artery shunt remains one of the most frequently used revascularization in emergency. Aims: Asses the role of age advancement in the incidence rate of post coronary artery shunt complications. Objectives: Several complications are reported after coronary artery bypass graft (CABG) surgery, such as postoperative arrythmia and postoperative stroke. However, the risk factors for the development remain not elaborated. Materials and methods: Retrospective analysis of the 290 patients who underwent coronary artery bypass graft from the Mordovia republic hospital for the period of 2017-2021. The results of the descriptive statistics demonstrated age dependent complications. Therefore, the sample subdivided into two groups, first group 126 patients (mean age: min; max, 55.21:41.00;60.00) and the second group 163 (M age: min; max, 66.11: 61.00; 80.00). For statistical analysis, we used the T test, one-way ANOVA test, and Pearson correlation test by using the Statistica 12 programme. Results: Post-CABG arrythmia developed in elderly patients, t-value -2.51307, p<0.012528. Subsequently, post-CABG arrythmia increased ICU and total hospitalisation days, t value -5.83306, p< 0.000000; t-value -4.02907, p< 0.000072, respectively. Elderly people are at higher risk of psychosis after CABG surgery, t value 2.69885, p <0.007379. psychosis significantly increases hospitalisation days in the ICU, t-value 3.86094, p < 0.000140. Postoperative stroke occurs more frequently in elderly people, t-value 2.087585, p < 0.037736. Subsequently, postoperative stroke increases the ICU hospitalization days, t-value 3.409293, p <0.000747. The number of ITAs used is less in the elderly people, t-value 2.41992, p < 0.016145. In terms of correlation, exist a direct association between age and ICU / total hospitalization days/number of complications, r= 0.189046, 0.141415, 0.138565; respectively. Conclusions: The number of complications is determined by age increase, CPB time, aortic cross-clamp time, the days of hospitalization in the ICU and total hospitalization days. Elderly people undergoing CABG are at higher risk of psychosis, arrythmia, longer total and ICU hospitalization days, and stroke. Others: Total hospitalization days depend on the presence of arrythmia, which is commonly seen in elderly patients > 63 years old.

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“…Many aspects of post-myocardial infarction (MI) changes remain unclear and require further investigation. Consequently, determining the precise life expectancy of MI patients remains challenging [6][7][8]. MI involves necrosis of myocardiocytes and disruption of the heart tissue's essential functions, including automaticity, conduction, and contractility.…”

Section: Introductionmentioning

confidence: 99%

Early Prognostic Instrumental and Laboratory Biomarkers in Post-MI

Marzoog,

Vanichkina

2023

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Background: Post-myocardial infarction (MI) changes have been reported frequently in the literature and are associated with the determination of the prognosis. Aims: To find a prognosis marker for the determination of the medium-term outcomes favorability in patients with acute MI. Objectives: MI victims prognosis is poorly understood and required further elaboration. Materials and methods: A single cross-sectional study involved 211 patients medical history with acute MI have been evaluated retrospectively for 76 parameters for the period 2014-2019. The data has been collected from the republic rehabilitation Mordovian hospital. Measurement units are used in the local laboratories has been used to describe the gotten values. The descriptive values are described in the mean average and standard deviation. For statistical analysis, descriptive statistics, t-test independent by groups and dependent by numerical variables for repeated analysis for the same patients, Pearsons correlation coefficient, ROC analysis, Stepwise Model Builder- logistic regression analysis, and for clarification purposes used diagrams and bar figures. For statistical analysis used the Statistica program. Results: Descriptive statistics showed a proportion of men to female 7:3. The mean age of the MI victims was 61,50 years (Std.Dev. 10,6875) and the mean height of the sample was 171,00 cm (Std.Dev. 7,2007). The mean body weight of the sample is 83,62 kg (Std.Dev. 12,3526) and the body mass index (BMI) is 29,02 kg/m2 (Std.Dev. 5,0791). The mean total hospitalization days is 14,79 (Std.Dev. 3,4125) days. The mean heart rate (HR) beat per minute (bpm) 79,03 (Std.Dev. 15,6370) and mean blood pressure 138,53/84,09 mmHg (Std.Dev. 28,6691/12,7971). On the complete blood count (CBC), the mean level of the hemoglobin (Hb) 136,332 g/l (Std.Dev. 15,2923), the mean level of the leukocytes (WBC) 8,768 /microL (Std.Dev. 2,7771), the mean level of the red blood cells (RBC) 4,559 /microL (Std.Dev. 0,5211), the mean level of the lymphocytes 24,469 % (Std.Dev. 9,0153), and the mean level of the thrombocytes 207,877 /microL (Std.Dev. 64,0350). The means erythrocytes segmentation rate (ESR) 18,990 mm/hr (Std.Dev. 12,1630). Conclusions: The gender plays an essential role for the development of ischemic heart disease including MI. The cut age in which females develop MI ≥73 years old. Patients with concomitant diseases have a high diastolic blood pressure and right ventricle size enlargement. The observed early post MI complication include left ventricle aneurysm and reinfarction. Others: a high calcium level is not a marker in hypertensive patients.

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Post-Coronary Artery Bypass Graft Complications; Potential Causes and Risk Factors

Cited by 6 publications

References 38 publications

Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior

Incidence Rate of Post Coronary Artery Shunt Complications; Age Dependent!

Early Prognostic Instrumental and Laboratory Biomarkers in Post-MI

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