We study the sensitivity of quality factor in single crystal silicon (SCS) micromechanical resonators to crystallographic axis misalignments that are present due to fabrication non-idealities. Our experimental results, being reported for the first time here, unveil that very small angular misalignment from [110] axis of transduction adversely affects the high Q of a bulk acoustic wave SCS resonator by more than 50%, unlike the misalignment errors about the [100] axis of transduction. Interestingly, when the axis of transduction is intentionally offset by a large angle from either [100] or [110], multiple peaks with comparable relative strength are observed from a single resonator.