Post Marketing Surveillance on Safety and Efficacy of IMOD in Iranian Patients with HIV/AIDS

Mohraz, Minoo; Sedaghat, Abbas; SeyedAlinaghi, SeyedAhmad; Asheri, Hossein; Mohammaddoust, Saeid; Gharibdoost, Farhad; Khorshid, Hamid Reza Khorram; Farhadi, Mohammad; Madani, Seyed Hesamedin; Kamali, Koorosh

doi:10.2174/18715265112129990031

Cited by 4 publications

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“…Until now IMOD has been shown to have beneficial effects in patients with severe sepsis, by lowering the levels of TNFα when compared with patients receiving only standard treatment ( Mahmoodpoor et al, 2010 ). Furthermore, IMOD has been shown to increase CD4 + T cell counts in HIV infected patients ( Mohraz et al, 2009 , 2013 ). Thus, IMOD has been shown to modulate immune responses during different inflammatory disorders ( Farhoudi et al, 2013 ) but little is known about the molecular mechanism of IMOD.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, IMOD has also been found to be effective in other types of immune inflammatory-based diseases such as ulcerative colitis and type I diabetes ( Mohammadirad et al, 2011 ). Furthermore, IMOD has a positive influence on the CD4 level in HIV infected individuals ( Mohraz et al, 2009 , 2013 ). These preclinical and clinical studies suggest that IMOD limits inflammatory responses but the mechanisms of immunodulation by IMOD remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells

et al. 2015

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Traditional medicines that stimulate or modulate the immune system can be used as innovative approaches to treat immunological diseases. The herbal medicine IMOD has been shown to strongly modulate immune responses in several animal studies as well as in clinical trials. However, little is known about the mechanisms of IMOD to modulate immunity. Here we have investigated whether IMOD modulates the immunological function of human dendritic cells (DCs). IMOD alone did not induce DC maturation nor production of cytokines. Notably, IMOD decreased the production of pro-inflammatory cytokines IL-6, IL-12 p70, and TNFα by LPS-activated DCs at both mRNA and protein levels in a dose dependent manner. In contrast, treatment with IMOD did not affect LPS induced-production of the anti-inflammatory cytokine IL-10. Furthermore, IMOD inhibited T cell activation/proliferation by LPS-treated DCs and skewed T-cells responses toward the T helper type 2 polarization. These data strongly indicate that IMOD has a potent immunomodulatory ability that affects TLR signaling and thereby modulates DC function. Insight into the immunomodulatory effect of herbal medicine IMOD may provide innovative strategies to affect the immune system and to help combat various diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells

et al. 2015

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Dawn of antioxidants and immune modulators to stop HIV-progression and boost the immune system in HIV/AIDS patients: An updated comprehensive and critical review

Singh

Pai

2015

Pharmacological Reports

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In the last two decades, human immunodeficiency virus (HIV), the retrovirus responsible for the acquired immunodeficiency syndrome (AIDS), is one of the leading causes of morbidity and mortality, worldwide. Providing the optimum management of HIV/AIDS is a major challenge in the 21st century. Since, HIV-infected persons have an extended lifespan due to the development of effective antiretroviral therapies, malnutrition is becoming central factors of long-term survivors. The nutrition status of AIDS patients has a significant influence on the maintenance and optimal effectiveness of the immune system. Micronutrient therapy in combination with allopathic treatments can extend and improve the quality and quantity of life in individuals infected with HIV/AIDS. HIV infection is thought to lead to augmented oxidative stress which may in turn lead to faster development of HIV disease. Hence, antioxidants might have a significant role in the treatment of HIV/AIDS. An additional approach to treating HIV infection is fortifying the immune response of infected people. Immune modulators help to activate and boost the normal immune function. The present review first describes the boon of antioxidants (especially Vitamin A) and immune modulators (cytolin, resveratrol, murabutide, setarud, tucaresol, AVR118, Immunitin (HE2000), reticulose, and interleukin-7) in the treatment of HIV/AIDS. Then, providing a comparatively succinct outline on updated patents study on antioxidants and immune modulators to treat HIV/AIDS will be discussed.

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Safety and Efficacy of Setarud (IMOD TM ) Among People Living with HIV/AIDS: A Review

Paydary¹,

Emamzadehfard²,

Khorshid³

et al. 2012

PRI

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The broad use of highly active anti-retroviral therapy (HAART), especially in developing world, has been associated with several problems such as lactic acidosis, lipodistrophy, pancreatitis, hyperlipidemia, insulin resistance and hepatotoxicity. Extensive use of HAART has also resulted in emergence of resistant HIV variants. Thereby, a pressing need for development of novel and cost-effective agents arises from these limitations. Setarud (IMOD™) is a safe, naturally- derived immunomodulator that was introduced for treatment of HIV patients in Iran. It is prepared as a mixture of herbal extracts including Tanacetum vulgare (tansy), Rosa canina and Urtica dioica (nettle) in addition to selenium, flavonoids and carotenes. Tanacetum vulgare may relieve anti-inflammatory symptoms and Rosa canina defers blood glucose and cholesterol elevation. Extracts from Urtica dioica may prevent maturation of myeloid dendritic cells and reduce T cell responses. A significant rise of CD4 count was observed in HIV patients treated by IMOD™ in clinical trial phases, which could be explained by its immunomodulatory effects. Anti-oxidative activity of compounds in IMOD™ might play a role in the clinical outcomes of patients treated with this drug. Moreover, IMOD™ may show improving activity upon lipid profile and liver metabolism. According to studies on IMOD™, it seems that IMOD™ has minor side effects. IMOD™ with international publication number WO 2007/087825 A1 is an herbal extract which includes Rosa canina, Urtica dioica, Tanacetum vulgare, and selenium comprising a treatment by pulsed electromagnetic field of high frequency and is useful in treatment of HIV infection and AIDS.

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Post Marketing Surveillance on Safety and Efficacy of IMOD in Iranian Patients with HIV/AIDS

Cited by 4 publications

References 0 publications

Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells

Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells

Dawn of antioxidants and immune modulators to stop HIV-progression and boost the immune system in HIV/AIDS patients: An updated comprehensive and critical review

Safety and Efficacy of Setarud (IMOD TM ) Among People Living with HIV/AIDS: A Review

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