Post-operative anaemia in femoral neck fracture patients: Does it need treatment? A single blinded prospective randomised controlled trial

Prasad, N.; Rajamani, Vijay; Hullin, David A.; Murray, JM

doi:10.1016/j.injury.2009.02.021

Cited by 34 publications

(38 citation statements)

References 12 publications

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“…Two RCTs reported the effects of postoperative oral iron supplements [63,65]. One trial reported 19% mortality in each group at one year, p = 1 and no effect on length of hospital stay [63].…”

Section: Tablementioning

confidence: 99%

A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips

2015

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SummaryWe systematically reviewed the observational associations of anaemia with outcomes and the effects of interventions to increase haemoglobin concentrations following hip fracture in older people. Anaemia on hospital admission was associated with increased mortality, relative risk 1.64 (95% CI 1.47-1.82), p < 0.0001. After adjustment for co-morbidities, the association of anaemia with increased mortality remained in four of eight observational studies. There was no association of postoperative transfusion with mortality after adjusting for covariates. Transfusion at 80 g.l À1 vs 100 g.l À1 increased acute myocardial infarction, relative risk 1.67 (95% CI 1.01-2.77), p = 0.05. Transfusion threshold was not associated with differences in other outcomes. There were insufficient high-quality studies to inform pre-operative blood transfusion or the use of peri-operative iron or erythropoietin. Studies for most interventions recruited too few participants to determine effects on infections, mortality or function.

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Section: Tablementioning

confidence: 99%

A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips

2015

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“…72,[89][90][91] A recent RCT assessing the effect of a six-week course of oral iron following hip fracture surgery concluded that there was no significant difference in length of hospital stay or one-year mortality rates between the iron and placebo groups. 92 In summary, despite mixed results, the current evidence broadly supports the use of intravenous iron or intravenous iron and erythropoietin in reducing transfusion rates following hip fracture surgery.…”

Section: Emergency Surgerymentioning

confidence: 99%

Anaemia in the older surgical patient: a review of prevalence, causes, implications and management

et al. 2013

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SummaryThis review provides the clinician with a summary of the causes, implications and potential treatments for the management of anaemia in the older surgical patient. The prevalence of anaemia increases with age and is frequently identified in older surgical patients. Anaemia is associated with increased postoperative morbidity and mortality. Allogenic blood transfusion is commonly used to treat anaemia but involves inherent risks and may worsen outcomes. Various strategies for the correction of preand postoperative anaemia have evolved. These include correction of nutritional deficiencies and the use of intravenous iron and erythropoesis stimulating therapy. Clear differences exist between the elective and emergency surgical populations and the translation of research findings into these individual clinical settings requires more work. This should lead to a standardized approach to the management of this frequently encountered clinical scenario.

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“…The eligible studies, the characteristics of which are summarised in Table 1, were published between 2004 and 2010 (inclusive) and included a total of 440 participants (219 in the iron group and 221 in the control group) with a mean age ranging from 70 to 83 years [10,37,38]. None of the participants were anaemic on admission; therefore, there was no work-up for anaemia.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…None of the participants were anaemic on admission; therefore, there was no work-up for anaemia. Two patients were lost to follow-up in one study [37]. All participants in the three studies had hip or knee arthroplasty, either electively or as an urgent procedure following trauma.…”

Section: Study Characteristicsmentioning

confidence: 99%

Systematic Review and Meta-Analysis: What Is the Evidence for Oral Iron Supplementation in Treating Anaemia in Elderly People?

Tay

Soiza

2015

Drugs Aging

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Post-operative anaemia in femoral neck fracture patients: Does it need treatment? A single blinded prospective randomised controlled trial

Cited by 34 publications

References 12 publications

A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips

A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips

Anaemia in the older surgical patient: a review of prevalence, causes, implications and management

Systematic Review and Meta-Analysis: What Is the Evidence for Oral Iron Supplementation in Treating Anaemia in Elderly People?

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