Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy

Camargo, J. B.; Steagall, Paulo V.; Minto, B. W.; Lorena, Sílvia Elaine Rodolfo de Sá; Mori, Eduardo Shigueru; Luna, Stélio Pacca Loureiro

doi:10.1111/j.1467-2995.2011.00609.x

Cited by 17 publications

(14 citation statements)

References 25 publications

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“…Considering the physiological function of two isoforms and the fact that firocoxib has a high COX-2 selectivity, firocoxib has a possibility to be an optimal NSAID to be used for controlling post-operative pain. Firocoxib has been approved for the control of post-operative pain in many countries and one study using firocoxib, before surgery has been reported [1]. However, the type of surgery and anesthetic procedure was the same in the report.…”

contrasting

confidence: 40%

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator's judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.

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contrasting

confidence: 40%

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

The Journal of Veterinary Medical Science

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“…Butorphanol is a short‐acting opioid analgesic with mild analgesic properties, which may not be adequate for the treatment of abdominal pain after ovariohysterectomy (Camargo et al. ). Similar findings were observed in previous epidemiological studies on the use of perioperative analgesic drugs: butorphanol was found to be widely used as an analgesic in Canada and Spain (Dohoo & Dohoo ; Gómez de Segura et al.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs

Catanzaro

Salvo

Steagall

et al. 2016

Veterinary Anaesthesia and Analgesia

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“…However, butorphanol is a short‐acting opioid analgesic (Camargo et al. ) and decreases in isoflurane requirements would be also short‐lived since plasma concentrations of the drug would be expected to decline over time.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the isoflurane‐sparing effects of fentanyl, lidocaine, ketamine, dexmedetomidine, or the combination lidocaine‐ketamine‐dexmedetomidine during ovariohysterectomy in dogs

Gutiérrez‐Blanco

Victoria-Mora

Ibancovichi-Camarillo

et al. 2013

Veterinary Anaesthesia and Analgesia

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Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy

Cited by 17 publications

References 25 publications

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs

Evaluation of the isoflurane‐sparing effects of fentanyl, lidocaine, ketamine, dexmedetomidine, or the combination lidocaine‐ketamine‐dexmedetomidine during ovariohysterectomy in dogs

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