Post‐operative outcomes in the elderly following colorectal cancer surgery

Abstract

Background: Despite the prevalence of colorectal cancer in the elderly, there has been a lack of recent studies examining surgical outcomes in these patients. Post-operative outcomes of colorectal cancer surgeries in those aged 80 and above will be compared to those younger than 80. Methods: A retrospective study was conducted of adults receiving surgical resections at a single tertiary centre for colorectal cancer diagnosed between January 2017 and December 2019. Patient demographics, mode of presentation, tumour demographics, operative data and post-operative outcomes were investigated. Results: Of the 326 patients included, 56 were aged 80 and above. Older patients were more likely to be female (P = 0.02), present with surgical emergencies or from other workup rather than through screening (P = 0.002), have more locally advanced cancers (P = 0.009) and receive less neoadjuvant therapy (P = 0.016). Despite this, they had comparable outcomes to those younger than 80 in terms of length of stay (P = 0.21) and rates of complications including mortality (P = 0.67). Conclusion: With appropriate patient selection and management, elderly patients can achieve comparable post-operative outcomes to their younger counterparts.

Are health outcomes in the older colorectal cancer patients treated by curative intent surgery any different to the younger patients?

“…It also was more meaningful than simply considering short-term outcomes such as 30-day mortality. 11 We found that those between 66-and 75-years had a higher OS compared to the two oldest age groups. We also found that our group of older patients had a higher rate of medical complications and on average stayed 1.5-2 days longer in hospital and had reduced OS compared to the younger patients.…”

“…We decided that it would be clinically relevant to prespecify a time period of 24 months in our comparison of these outcomes between our four categories, as many older patients from our anecdotal clinical experience found it as a useful reference time period to consider in their surgical planning and discussions. It also was more meaningful than simply considering short‐term outcomes such as 30‐day mortality 11 …”

Is preoperative physical function testing predictive of length of stay in patients with colorectal cancer? A retrospective study

“…Some studies have been conducted to investigate the effect of age on surgical outcomes in CRC patients. More recently, Park et al (2021) aimed to compare post-operative outcomes following CRC surgery in patients below and over 80 years of age. All patients were treated within the ERAS pathway.…”

The Analysis between Clinicopathological Aspect of Early-Onset vs Late-Onset Colorectal Cancer and Mortality Rate

“…Comorbidities in subjects can increase the risk of postoperative mortality rate. 1,11 Mortality rate as a postoperative outcome is a patient's postoperative outcome based on the condition of life or death. 12 Nowadays, there have only been studies abroad that have compared the clinicopathological characteristics of early-onset and late-onset colorectal cancer (EOCRC vs LOCRC) [13][14][15] , but there is a lack of data that analyse the correlation between these clinicopathological aspects and post-operative outcomes such as mortality rates, especially in developing countries like Indonesia.…”