Post‐partum Necrosis of the Anterior Pituitary; Pathological and Clinical Aspects

Sheehan, H. L.; Murdoch, R.

doi:10.1111/j.1471-0528.1938.tb11140.x

Cited by 106 publications

(27 citation statements)

References 17 publications

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“…Pituitary infarction can be seen with various conditions associated with vascular occlusion or simply hypoperf usion, leading to ischemia and cell death [12]. The complication of pituitary infarction is well known in the setting of massive obstetrical hemorrhage during delivery [13]. [15], it is an extremely rare condition.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of Acromegaly after Pituitary Infarction Due to Gastrointestinal Hemorrhage from Gastric Ulcer.

et al. 1999

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Section: Introductionmentioning

confidence: 99%

Amelioration of Acromegaly after Pituitary Infarction Due to Gastrointestinal Hemorrhage from Gastric Ulcer.

et al. 1999

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“…As such, anti-coagulation with non-pulsatile blood flow is implicated in apoplexy following CABG (Davies & Scanlon 1998), and hypotension may underlie the phenomenon in post-partum haemorrhage (Sheehan & Murdoch 1938). Furthermore, pituitary stimulation during dynamic function testing may impose further demands on the tenuous pituitary tumour blood supply producing ischaemia with infarction (Okuda et al 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, apoplexy must be diagnosed and treated urgently if significant morbidity and mortality are to be avoided. As such, the recognition of potential precipitants is important and reported causes include coronary artery bypass surgery (CABG) (Davies & Scanlon 1998), post-partum haemorrhage (Sheehan & Murdoch 1938), dopamine agonist therapy (Shirataki et al 1988) and pituitary stimulation testing (Okuda et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Pituitary apoplexy following combination chemotherapy - a case report

Davies¹,

Rees²,

Evans³

et al. 1998

Endocrine Related Cancer

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We report a case of apoplexy of an undiagnosed pituitary adenoma in a patient treated with intravenous combination chemotherapy for squamous cell carcinoma of the penis. Apoplexy occurred while he was receiving a second cycle of vinblastine, cisplatin and methotrexate and he presented with classic neuro-ophthalmological signs. He made a full recovery following conservative manageEndocrine-Related Cancer (1998) 5 151-153 ment with steroids alone.

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“…Panhypopituitarism may occur spontaneously, develop after surgery or radiation of pituitary adenomas, or develop after severe postpartum hemorrhage (Sheehan's syndrome). Sheehan's syndrome exhibits characteristic manifestations including failure to lactate or resume menses, loss of genital and axillary hair, and, in severe cases, evidence of hypopituitarism [5,6]. But clinical manifestations are developed in patients with Sheehan's syndrome at a variety of intervals ranged from one month to 47 yr after the delivery [4,7].…”

Section: The Hematopoiesismentioning

confidence: 99%

A Case of Sheehan's Syndrome Associated with Severe Anemia and Empty Sella Proved 48 Years After Postpartum Hemorrhage.

et al. 1995

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Abstract. A 68-year-old woman was admitted to our hospital for severe normochromic and normocytic anemia. She had a history of prolonged postpartum hemorrhage at the age of 20 yr. Her menses were resumed thereafter and she gave birth to two other children, but her lactation was poor. She had no subjective symptom until the age of 63 yr when she complained of weakness and cold intolerance. Laboratory examination at admission revealed severe anemia (Hb 7.2 g/dl) with relatively low serum erythropoietin (EPO 20.4 mIU/ml) and panhypopituitarism.Empty sella was also found by magnetic resonance imaging (MRI). Hb levels were corrected by replacement with levothyroxine (75 µg/day) and hydrocortisone (10 mg/day), which was accompanied by an increase in serum EPO levels. These findings indicate that this is a very rare case of Sheehan's syndrome with severe anemia and empty sella proved at the longest reported interval of 48 yr after the provoking delivery, and that serum EPO levels are increased by replacement with glucocorticoid and thyroxin in panhypopituitarism.

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Post‐partum Necrosis of the Anterior Pituitary; Pathological and Clinical Aspects

Cited by 106 publications

References 17 publications

Amelioration of Acromegaly after Pituitary Infarction Due to Gastrointestinal Hemorrhage from Gastric Ulcer.

Amelioration of Acromegaly after Pituitary Infarction Due to Gastrointestinal Hemorrhage from Gastric Ulcer.

Pituitary apoplexy following combination chemotherapy - a case report

A Case of Sheehan's Syndrome Associated with Severe Anemia and Empty Sella Proved 48 Years After Postpartum Hemorrhage.

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