Post-radiation dedifferentiation of meningioma into osteosarcoma.

Osipov, Vladimir; Ho, Khang-Che; Krouwer, Hendrikus G. J.; Meyer, Glenn A.; Shidham, Vinod B.

doi:10.1186/1471-2407-2-34

Cited by 23 publications

(18 citation statements)

References 13 publications

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“…previously reported two cases of meningeal sarcoma with leiomyoblastic differentiation, one of which showed an additional meningothelial component at the first surgery . These reports have a commonality in terms of their recurrent tumors, which showed predomination of the sarcoma component in comparison to the meningioma component . Similarly, our present case is unique in that it showed mixed chordoid meningioma and rhabdomyosarcoma in the first resected specimen and a gradual increase in the sarcoma component.…”

Section: Discussionsupporting

confidence: 60%

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Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa

et al. 2016

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A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months. When subsequent recurrences were observed, the patient was treated by surgery, stereotactic radiosurgery and chemotherapy. Thirty-two months after the initial treatment, the patient died due to intracranial dissemination and an autopsy was performed. The histological examination of the recurrent and autopsy specimens showed a prominent sarcoma component. This case appears to be the first reported intracranial tumor diagnosed as a dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation.

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Section: Discussionsupporting

confidence: 60%

“…Osipov et al . reported a case of radiation‐induced dedifferentiation of meningioma into osteosarcoma . Our case suggests that radiotherapy did not play a role in the development of the sarcoma component, since the rhabdomyosarcoma was present in the first resection specimen.…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa

et al. 2016

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“…Even exposure to low radiation doses has been shown to significantly increase the risk of meningioma [9;10]. Adding to the increasing concerns of radiation therapy for meningioma, radiation has been shown to induce de-differentiation of meningioma into osteosarcoma in two independent studies [11;12]. All of these studies document the phenomenon of radiation resistance with meningioma but the precise mechanism of action (e.g., repair, cell cycle control or some other responsible process) is yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Chk2-mediated G2/M cell cycle arrest maintains radiation resistance in malignant meningioma cells

et al. 2011

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In continuation to our studies on radioresistance in meningioma, here we show that radiation treatment (7Gy) induces G2/M cell cycle arrest in meningioma cells. Phosphorylation of Chk2, Cdc25c and Cdc2 were found to be key events since interference with Chk2 activation and cyclin B1/Cdc2 interaction led to permanent arrest followed by apoptosis. Irradiated cells showed recovery and formed aggressive intracranial tumors with rapid spread and morbidity. Nevertheless, knock down of uPAR with or without radiation induced permanent arrest in G2/M phase and subsequent apoptosis in vitro and in vivo. In conclusion, our data suggest that combination treatment with radiation and uPAR knockdown or other inhibitors resulting in non-reversible G2/M arrest may be beneficial in the management of meningiomas.

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“…The MIB-1 LI rose from less than 1% at the first operation to 13% at the latest operation. Although malignant transformation due to irradiation has been described in various cases of intracranial tumors, 10,12,25 it has never been reported in cases of SFT. Irradiation may induce tumor cells to become malignant with an increased MIB-1 LI; however, in this case there was no direct evidence to support such a hypothesis.…”

Section: Discussionmentioning

confidence: 95%

Recurrent intracranial solitary fibrous tumor with cerebrospinal fluid dissemination

Miyashita

Hayashi

Fujisawa

et al. 2004

Journal of Neurosurgery

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Solitary fibrous tumor (SFT) is a benign and rare neoplasm. To date, only 37 patients with intracranial SFTs have been reported. Although a number of the tumors were recurrent and some later underwent malignant transformation, none of these lesions progressed to cerebrospinal fluid (CSF) dissemination. In this paper the authors report a case of SFT in which the lesion recurred several times and ultimately was disseminated by the CSF. The patient was a 63-year-old woman with multiple intracranial and spinal tumors. Fifteen years before this presentation, at the age of 48 she had been hospitalized for resection of a falcotentorial tumor. During the ensuing 15 years she underwent multiple surgeries and sessions of radiation therapy for recurrent lesions. The exclusive location of her tumors in the subarachnoid space at the end of this 15-year period indicate CSF dissemination of the tumor. The tumor that was resected when the patient was 48 years old and the latest resected lesion were analyzed by performing immunohistological CD34, epithelial membrane antigen, vimentin, S100 protein, and reticulin staining, and determining the MIB-1 labeling index (LI). Most of the results were identical, and both tumors were diagnosed as SFT according to a staining pattern that showed a strong and diffuse positive reaction for CD34. Nevertheless, the authors noted that the MIB-1 LI increased from less than 1% in the original tumor to 13% in the latest tumor. The increased proliferation of MIB-1 indicates that the malignant transformation could have occurred during tumor recurrence with CSF dissemination.

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Post-radiation dedifferentiation of meningioma into osteosarcoma.

Abstract: Background: A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously.

Cited by 23 publications

References 13 publications

Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa

Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa

Chk2-mediated G2/M cell cycle arrest maintains radiation resistance in malignant meningioma cells

Recurrent intracranial solitary fibrous tumor with cerebrospinal fluid dissemination

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