Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

Fan, Jiankun; Li, Zhigang; Pei, Li; Hou, Yu

doi:10.1016/j.gendis.2024.101252

Genes & Diseases

2024

DOI: 10.1016/j.gendis.2024.101252

|View full text |Cite

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

Jiankun Fan,

Zhigang Li,

Li Pei

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Essential role of Dhx16-mediated ribosome assembly in maintenance of hematopoietic stem cells

Li,

Fan,

Xiao

et al. 2024

Leukemia

View full text Add to dashboard Cite

Essential role of Dhx16-mediated ribosome assembly in maintenance of hematopoietic stem cells

Li,

Fan,

Xiao

et al. 2024

Leukemia

View full text Add to dashboard Cite

DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host–Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications

Xiao,

Fan,

et al. 2024

IJMS

View full text Add to dashboard Cite

DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. Its diverse functions in cancer progression and viral infections have attracted considerable attention. DDX21 exerts a pivotal function through ribosomal DNA (rDNA) transcription and rRNA processing. DDX21 is involved in different biological processes of mRNA transcription. It interacts with transcription factors, modulates RNA polymerase II elongation, binds R-loops to regulate transcription, and participates in alternative splicing. The elevated expression of DDX21 has been observed in most cancers, where it influences tumorigenesis by affecting ribosome biogenesis, transcription, genome stability, and cell cycle regulation. Additionally, DDX21 plays a key role in the antiviral defense of host by interacting with viral proteins to regulate essential stages of the infection process. This review provides a thorough examination of the biological functions of DDX21, its involvement in cancer progression and viral infections, and its potential as both a biomarker and a therapeutic target. Future studies should aim to clarify the specific mechanisms of the activity of DDX21, advance the development of targeted therapies, and assess its clinical relevance across various cancer types and stages.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

Cited by 2 publications

References 87 publications

Essential role of Dhx16-mediated ribosome assembly in maintenance of hematopoietic stem cells

Essential role of Dhx16-mediated ribosome assembly in maintenance of hematopoietic stem cells

DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host–Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications

Contact Info

Product

Resources

About