Post‐transcriptional regulation of the Ras‐ERK/MAPK signaling pathway

Whelan, Jarrett T.; Hollis, Sarah; Seok, Dong; Asch, Adam S.; Lee, Myon‐Hee

doi:10.1002/jcp.22899

Cited by 84 publications

(69 citation statements)

References 102 publications

(133 reference statements)

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“…However, ERK is commonly activated by the classic Raf/MEK/ERK signaling pathway to repress apoptosis. Activated ERK can up-regulate the expression of Bcl-2, activate the transcription factors Elk-1 and ATF2 and regulate the cell cycle to promote proliferation (Whelan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells

Zeng

Dai

Jiang

et al. 2015

Pharmaceutical Biology

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Curcumin inhibited SHI-1 cell proliferation by arresting the cells in the S-phase, increasing the number of Annexin V-FITC + /PI À cells and promoting the loss of 4W m . The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-jB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3. Additionally, curcumin partially suppressed SHI-1 cell invasion and attenuated the mRNA transcription and secretion of MMP-2 and MMP-9. Discussion and conclusion: This study demonstrates that curcumin not only induces SHI-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK, P38 MAPK and ERK signaling, but also partially suppresses SHI-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9. KeywordsAntitumor, matrix metalloproteinase, mitogen-activated protein kinase History

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Section: Discussionmentioning

confidence: 99%

Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells

Zeng

Dai

Jiang

et al. 2015

Pharmaceutical Biology

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“…These genes are closely associated with the extracellular-signal regulated protein kinase (ERK)/MAPK signaling pathway, and mediate various biological events involved in cell proliferation, differentiation and survival (17).…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of WWOX growth inhibitory effects on oral squamous cell carcinoma

et al. 2017

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Abstract. Oral squamous cell carcinoma (OSCC) is one of the most common types of head and neck neoplasms in the world. Patients diagnosed with OSCC exhibit a poor prognosis. WW domain-containing oxidoreductase (WWOX), as a candidate tumor-suppressor gene, is involved in the genesis and progression of tumors. The deletion of the WWOX gene has been identified in OSCC and oral leukoplakia, but the function and mechanism of WWOX in OSCC remain unknown. Therefore, the present study investigated the role of WWOX in oral squamous carcinoma cells. The results revealed that an elevation of WWOX expression had an inhibitory effect on the growth of three types of oral squamous carcinoma cells, with the most evident effect occurring in Tca8113 cells. Also, in the Tca8113 cells, WWOX overexpression significantly inhibited colony formation, and induced apoptosis and cell cycle arrest. Microarray analysis, reverse transcription-quantitative polymerase chain reaction and western blotting methods detected that WWOX overexpression contributed to the differential expression of the genes involved in mediating the extracellular-signal regulated protein kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway. These results suggest that the tumor-suppressor function of the WWOX gene may be associated with the modulation of the ERK/MAPK signaling pathway, thus providing a novel target for OSCC therapy.

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“…Between these two points, there are a series of events including processing and splicing of the pre-mRNA, export of the message from the nucleus to the cytoplasm, quality control assessment of the mRNA through the pioneer round of translation, message decay and stabilization, and translational repression and de-repression [37]. All of these events from initiation of transcription by transcription factors to the stability of the message to effective translation of the message are controlled by the presence of specific nucleotide sequences which are bound by specific RNA-binding proteins [38].…”

Section: Post-transcriptional Gene Regulationmentioning

confidence: 99%

Post-transcriptional gene regulation by RNA-binding proteins in vascular endothelial dysfunction

Xin

Deng

2014

Sci. China Life Sci.

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Endothelial cell dysfunction is a term which implies the dysregulation of normal endothelial cell functions, including impairment of the barrier functions, control of vascular tone, disturbance of proliferative and migratory capacity of endothelial cells, as well as control of leukocyte trafficking. Endothelial dysfunction is an early step in vascular inflammatory diseases such as atherosclerosis, diabetic vascular complications, sepsis-induced or severe virus infection-induced organ injuries. The expressions of inflammatory cytokines and vascular adhesion molecules induced by various stimuli, such as modified lipids, smoking, advanced glycation end products and bacteria toxin, significantly contribute to the development of endothelial dysfunction. The transcriptional regulation of inflammatory cytokines and vascular adhesion molecules has been well-studied. However, the regulation of those gene expressions at post-transcriptional level is emerging. RNA-binding proteins have emerged as critical regulators of gene expression acting predominantly at the post-transcriptional level in microRNA-dependent or independent manners. This review summarizes the latest insights into the roles of RNA-binding proteins in controlling vascular endothelial cell functions and their contribution to the pathogenesis of vascular inflammatory diseases.

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Post‐transcriptional regulation of the Ras‐ERK/MAPK signaling pathway

Cited by 84 publications

References 102 publications

Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells

Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells

Exploring the mechanism of WWOX growth inhibitory effects on oral squamous cell carcinoma

Post-transcriptional gene regulation by RNA-binding proteins in vascular endothelial dysfunction

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