Post-Traumatic Glioblastoma Multiforme: A Case Report

Abstract

Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A 65-year-old man was admitted because of right sided hemiplegia, epilepsy and changes in consciousness due to a malignant glial tumor. He had been operated on for a left calvarial depression fracture caused by cerebral laceration thirty-five years before. Radiologic imaging revealed a large contrast-enhanced mass lesion at the left frontotemporoparietal junction under the depression site. The patient underwent urgent surgery, and radical excision of the mass was achieved. The histopathologic diagnosis was a highgrade glial tumor. Although the possibility of a pre-existing tumor rather than a trauma-induced tumor is very high, the presented case suggests that traumatic cerebral lesions may also be a predisposing factor for the development of malignant glial tumors. Key Words: Brain injury, Glial cell tumors, Trauma ÖzetTravma sonrasında malign glioma gelişimi çok nadir gelişen bir durumdur. Atmışbeş yaşındaki erkek hasta malign glial tümör nedeniyle gelişen sağ hemipleji, epilepsi ve bilinç kaybı ile kliniğimize kabul edildi. Hasta 35 yıl önce sol kalvaryal depresyon fraktürüne bağlı serebral laserasyon nedeniyle ameliyat edilmiştir. Radyolojik görün-tülemede depresyon alanının altında sol frontotemporoparyetal loblarda kontrast tutan büyük bir kitle lezyonu göstermekteydi. Hasta acil operasyona alınarak radikal kitle eksizyonu uygulandı. Önceden mevcut bir tümör olma olasılığı travma kaynaklı tümörden çok yük-sek olmasına rağmen, sunulan olguda travmatik beyin lezyonu malign glial tümör gelişiminde predispozan bir faktör olabilir.

Bayesian Space–Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010–2013

“…Our results have shown that in Southern Ontario between 2010-2013, there was a positive association between brain cancer risk and two health-related factors, namely traumatic injuries to the head and high body fat levels. Regarding THI, our findings were in accordance with previous studies from the medical sciences where severe head injuries were found to be a potential predisposing factor for the onset of brain cancer [58][59][60]. From a neurological perspective, Spallone et al [7] explained that cancerous brain tumors are commonly formed in the anatomical vicinity of sites where previous head injuries have occurred.…”

Potential Risk Factors of Glioblastoma Multiforme in Greek Adults: A Case- Control Study

“…A strong association was recorded in the current study, finding that was in agreement with those from previous reports, in which a clear evidence for such a causative role was presented [73,[75][76][77]. Other authors suggested that GBM following a traumatic cerebral contusion is possible [24,78]. In some of those cases, the histopathological diagnosis was a prolongation of the gliotic scar of the tumor and persisting splinters were found in the glioma nests many years after TBI [72,75].…”

The First into the Dark: The Nazi Persecution of the Disabled

“…221 The paper was cited as a reference in the scientific literature as recently as 2011. 222 It would later be established by historians that Werner was one of at least 340 children and adolescents from the Brandenburg-Görden State Hospital who were murdered at the Brandenburg killing centre, so that their brains could be harvested for research at the KWI laboratories. ____ Julius Hallervorden was born in 1882 in Allenberg, East Prussia.…”