Post-traumatic malignant glioma. Report of a case

Trapani, G. Di; Carnevale, Antonio; Scerrati, Massimo; Colosimo, Cesare; Vaccario, M. L.; Mei, D.

doi:10.1007/bf01997787

Cited by 20 publications

(21 citation statements)

References 8 publications

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“…The development of glioblastoma multiforme following a traumatic cerebral contusion is possible [18]. There are several case reports in the literature that discuss posttraumatic gliomas [1][2][3][4][5][6][7][8][9][10][11][12], but some of these cases might only be a statistical coincidence. Hochberg et al [10] demonstrated that severe head injury is a significant risk factor for the development of glial tumors.…”

Section: Discussionmentioning

confidence: 99%

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Post-Traumatic Glioblastoma Multiforme: A Case Report

Coşkun

Coskun

Gürsan

et al. 2011

EAJM

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Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A 65-year-old man was admitted because of right sided hemiplegia, epilepsy and changes in consciousness due to a malignant glial tumor. He had been operated on for a left calvarial depression fracture caused by cerebral laceration thirty-five years before. Radiologic imaging revealed a large contrast-enhanced mass lesion at the left frontotemporoparietal junction under the depression site. The patient underwent urgent surgery, and radical excision of the mass was achieved. The histopathologic diagnosis was a highgrade glial tumor. Although the possibility of a pre-existing tumor rather than a trauma-induced tumor is very high, the presented case suggests that traumatic cerebral lesions may also be a predisposing factor for the development of malignant glial tumors. Key Words: Brain injury, Glial cell tumors, Trauma ÖzetTravma sonrasında malign glioma gelişimi çok nadir gelişen bir durumdur. Atmışbeş yaşındaki erkek hasta malign glial tümör nedeniyle gelişen sağ hemipleji, epilepsi ve bilinç kaybı ile kliniğimize kabul edildi. Hasta 35 yıl önce sol kalvaryal depresyon fraktürüne bağlı serebral laserasyon nedeniyle ameliyat edilmiştir. Radyolojik görün-tülemede depresyon alanının altında sol frontotemporoparyetal loblarda kontrast tutan büyük bir kitle lezyonu göstermekteydi. Hasta acil operasyona alınarak radikal kitle eksizyonu uygulandı. Önceden mevcut bir tümör olma olasılığı travma kaynaklı tümörden çok yük-sek olmasına rağmen, sunulan olguda travmatik beyin lezyonu malign glial tümör gelişiminde predispozan bir faktör olabilir.

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Section: Discussionmentioning

confidence: 99%

“…Trauma has been implicated as a predisposing factor in patients with malignant gliomas [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. However, only a few authors have provided definite evidence for a causative role of trauma in this disease [7,15].…”

Section: Introductionmentioning

confidence: 99%

Post-Traumatic Glioblastoma Multiforme: A Case Report

Coşkun

Coskun

Gürsan

et al. 2011

EAJM

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“…Regenerative and scarring processes following trauma have been thought play some role to stimulate neoplastic transformation. Tumor should arise from old trauma scar for a causal relationship to establish [7]. If the tumor arises at different site of the old lesion, should be coincidence [8].…”

Section: Discussionmentioning

confidence: 99%

Post Traumatic Glioma – An association questioned

Chaurasia¹,

Chaudhary²,

Verma³

et al. 2015

Romanian Neurosurgery

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Post traumatic glioma has been a matter of debate. Few reports favor its occurrence in previous head injury scar, subsequently developing into glioma. Here we report a case of young patient presented with headache, seizures and gradual loss of vision. On investigation found to have brain tumor. Patient had head injury occurred 3 yrs back. It fulfills all the criteria required to establish traumatic origin, further supporting the association.

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“…23 However, the presented case show formation of GBM at the site of prior brain injury. 2,3,6,7,[9][10][11][12][13][14][15]18 Trauma and glial scarring are known to be predisposing factors for the development of malignant glial tumors. 25 The development of glioblastoma multiforme following a traumatic cerebral contusion is possible.…”

Section: Discussionmentioning

confidence: 99%