Post‐traumatic stress symptoms among mothers of children with leukemia undergoing treatment: a longitudinal study

Tremolada, Marta; Bonichini, Sabrina; Aloisio, Donatella; Schiavo, Simone; Carli, Modesto; Pillon, Marta

doi:10.1002/pon.3132

Cited by 35 publications

(39 citation statements)

References 46 publications

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“…One study found that lower education was associated with higher depression scores and PTSS up to 1 year post‐diagnosis (Demirtepe‐Saygili & Bozo ; Tremolada et al . ). Notably, family income was not associated with distress (Klassen et al .…”

Section: Resultsmentioning

confidence: 97%

“…; Tremolada et al . ). Tumour relapse was also as a significant predictor for the prevalence of traumatic stress, with traumatic stress nearly doubling following relapse (Jurbergs et al .…”

Section: Discussionmentioning

confidence: 97%

“…; Tremolada et al . ). However, other reports suggested that a significant proportion of parents continue to experience psychological difficulties in the long run (between 18% and 30%) (Hardy et al .…”

Section: Introductionmentioning

confidence: 97%

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A systematic review on factors and consequences of parental distress as related to childhood cancer

et al. 2015

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The literature including correlates of parental distress as related to childhood cancer is abundant. It is important to identify predictive factors and outcomes of this distress in parents. The objective of this review was to update previous syntheses on factors of distress and to identify outcomes of parents’ distress in the recent literature (2007–2012). We performed a systematic review to identify all quantitative studies including measures of parental distress and associated factors during the study period. We found 56 eligible studies, of which 43 had a Low risk of bias (Cochrane guidelines). Forty‐two reports included potential predictive factors. Significant relationships were found with clinical history of the child, sex of the parent, coping response and personal resources, pre‐diagnosis family functioning, but not education/income or marital status. Twenty‐five reports studied potential consequences of distress and focused on psychological adjustment in parents and children. Compared to past periods, a higher proportion of studies included fathers. Measures used to evaluate distress were also more homogeneous in certain domains of distress. This review underscores the need for appropriate methods for selecting participants and reporting results in future studies. Appropriate methods should be used to demonstrate causality between factors/consequences and distress.

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Section: Resultsmentioning

confidence: 97%

“…; Tremolada et al . ). Tumour relapse was also as a significant predictor for the prevalence of traumatic stress, with traumatic stress nearly doubling following relapse (Jurbergs et al .…”

Section: Discussionmentioning

confidence: 97%

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A systematic review on factors and consequences of parental distress as related to childhood cancer

et al. 2015

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“…Variability in the experience of closeness has been proposed to reflect baseline differences across families or differences in the illness and treatment challenges faced by couples . The 1 quantitative study of couple's closeness indicated that female partners reported a significant increase in emotional closeness with their partners from diagnosis to 1 year postdiagnosis …”

Section: Resultsmentioning

confidence: 99%

Couple functioning after pediatric cancer diagnosis: a systematic review

et al. 2016

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“…There are a variety of factors that were not evaluated in this review, such as the influence of health status and lifestyle (metabolic syndromes, chronic conditions, nutritional status, symptoms management, physical activity and psychological well-being)(Badr et al,2013; Brinkman et al,2013; Hartman et al,2013; Huang et al,2013; Tonorezos et al,2013), environmental factors (coping strategies, education and psychological status of family members)(Norberg and Boman,2008; Trask et al,2009; Tremolada et al,2013; Long et al,2014; Williams et al,2014; Williams and McCarthy,2014 ) and the interaction between chemotherapy and other supportive care drugs that may exert additive neurotoxic effects (antibiotics, antifungals and neuropsychiatric drugs)(Haidar and Jeha,2011; van Schie et al,2011; Barrett et al,2013; Ruggiero et al,2013). A multidisciplinary approach is needed to ascertain the impact of contemporary ALL treatments on these adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review

Cheung

Krull

2015

Neuroscience & Biobehavioral Reviews

145

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The intensified administration of chemotherapeutic drugs has gradually replaced cranial radiation therapy (CRT) for the treatment of childhood acute lymphoblastic leukemia (ALL). While CRT is often implicated in neurocognitive impairment in ALL survivors, there is a paucity of literature that evaluates the persistence of neurocognitive deficits in long-term survivors of pediatric ALL who were treated with contemporary chemotherapy-only protocols. Results from this systematic review concurred to the probable cognitive-sparing effect of chemotherapy-based protocols over CRT in long-term survivors. However, coupled with multiple intrinsic and extrinsic factors, survivors who received chemotherapy treatment still suffered from apparent cognitive impairment, particularly in the attention and executive function domains. Notably, there is evidence to suggest that the late neurotoxic effect of methotrexate on survivors’ neurocognitive performance may be dose-related. This review also recommends future pharmacokinetic, neuroimaging and genetic studies to illuminate the multifactorial nature of this subject matter and discusses the potential value of neurochemical, physiological, inflammatory and genetic markers for the prediction of susceptibility to neurocognitive impairment in long-term survivors of childhood ALL.

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Post‐traumatic stress symptoms among mothers of children with leukemia undergoing treatment: a longitudinal study

Abstract: Specific psychological interventions could be devised for mothers at risk for short and long-term PTSS just after the diagnosis.

Cited by 35 publications

References 46 publications

A systematic review on factors and consequences of parental distress as related to childhood cancer

A systematic review on factors and consequences of parental distress as related to childhood cancer

Couple functioning after pediatric cancer diagnosis: a systematic review

Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review

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