Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat

Lee, Jun Young; Kwak, Ihm Soo; Lee, Soo Bong; Song, Sang Heon; Seong, Eun Young; Yang, Byeong Yun; Lee, Min Young; Sol, Mee Young

doi:10.3346/jkms.2009.24.s1.s170

Cited by 18 publications

(14 citation statements)

References 24 publications

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“…Also, Lee et al. [23] suggested that NDGA (nordihydroguaiaretic acid), a 5‐lipoxygenase inhibitor, accelerates renal function recovery in cisplatin‐induced acute renal failure rats.…”

Section: Discussionmentioning

confidence: 99%

Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats

Suddеk

2011

Fundamemntal Clinical Pharma

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“…Also, Lee et al. [23] suggested that NDGA (nordihydroguaiaretic acid), a 5‐lipoxygenase inhibitor, accelerates renal function recovery in cisplatin‐induced acute renal failure rats.…”

Section: Discussionmentioning

confidence: 99%

Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats

Suddеk

2011

Fundamemntal Clinical Pharma

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“…The GM and erythropoietin treatment protocols used in the present study have been reported previously (25,26).…”

Section: Drugsmentioning

confidence: 99%

Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study

et al. 2012

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Background:Investigations have attempted to modify the outcome of tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis. Objectives: We investigated the protective effect of Eprex an erythropoietin analogue on tubular injury induced by gentamicin (GM). Materials and Methods: Forty male Wistar rats were randomly divided into four groups. In group 1,rats were served as a sham group. In group 2, rats were injected intraperitoneally with 100 mg/kg of GM for 10 consecutive days (positive control group) and then were sacrificed. In group 3, rats received GM for 10 days then Eprex 100U/kg was injected intraperitoneally for the next 10 days and then they were sacrificed at the day 20th. In group 4 rats were injected a combination of GM (80 mg/kg) and Eprex 100U/kg intraperitoneally for 10 days and then were sacrificed. Results: The results indicated that, Eprex prevented the increase in serum creatinine (Cr) and blood urea nitrogen (BUN). The effect of Eprex on damage score, showed that co-administration of GM and Eprex (group 3 and 4) reduced the kidney tissue damage compared to positive control group (P<0.05). This result indicat that Eprex potentially can reduce or prevent the kidney tissue damage. Conclusions: Ameliorative effect of Eprex when the drug was given in combination with GM and also when the drug was applied after GM-induced tubular damage, revealed the renoprotective potency of Eprex. Eprex is a promising drug to prevent or attenuate tubular damage induced by GM or other nephrotoxic agents which act through the same mechanisms as gentamicin.

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“…The PCNA is also involved in DNA synthesis and repair, acting as an auxiliary factor of DNA polymerase δ. The number of PCNA-positive stained cells is recognized as an important index reflecting cell proliferation [29, 30]. Previous studies suggested that expression of glomerular PCNA in LN increased, and the degree was positively correlated with glomerular proliferation [29].…”

Section: Discussionmentioning

confidence: 99%

Experimental research The effect of esculentoside A on lupus nephritis-prone BXSB mice

Ma¹,

Zhang²,

Zhang³

et al. 2013

aoms

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IntroductionEsA was reported to have the effect of modulating immune response, cell proliferation and apoptosis as well as anti-inflammatory effects in acute and chronic experimental models. However, the effects of EsA on LN remain poorly understood. To investigate the roles of EsA in LN, the effects of EsA were tested on BXSB mice, a SLE model, in which male SB/Le mice and female C57BL/6 mice were hybridized through recombinant inbred species.Material and methodsTwenty four BXSB mice were divided into three groups. After 4 weeks, blood samples, urine samples and kidney tissues were collected. Measurement of cytokine levels was carried out using sandwich ELISA reagent kits. Apoptotic scores were obtained with a TUNEL assay. PCNA and Caspase-3 mRNA was detected using the In Situ Hybridization Detection Kit.ResultsThe results demonstrated that compared with the control group, EsA administration markedly controlled urine protein excretion, improved renal function, alleviated kidney damage and promoted the apoptosis of glomerular intrinsic cells and renal tubular epithelial cells in animals of the treated group (p < 0.05). Meanwhile, EsA reduced the serum IL-6 and TNF-α levels (p < 0.05), inhibited the expression of PCNA and promoted the expression of caspase-3, Fas and FasL in animals of the treated group (p < 0.05). The effects of EsA on BXSB mice were similar to dexamethasone.ConclusionsAll these findings indicated that EsA might play significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis. The special targets of EsA in lupus nephritis are worth further exploration.

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Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat

Cited by 18 publications

References 24 publications

Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats

Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats

Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study

Experimental research The effect of esculentoside A on lupus nephritis-prone BXSB mice

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