Post-tuberculous lung function impairment in a tuberculosis reference clinic in Cameroon

Ngahane, Bertrand Hugo Mbatchou; Nouyep, Junior; Motto, Malea Nganda; Njankouo, Yacouba Mapoure; Wandji, A.; Endale, Mireille; Ze, E. Afane

doi:10.1016/j.rmed.2016.03.007

Cited by 35 publications

(28 citation statements)

References 20 publications

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“…It was observed that 57% patients were male while 43% were female. The observed results were found in accordance with a study done by Bertrand Hugo Mbatchou Ngahane et al 21 As per the study out of the 269 participants included in the study, 146 (54.3%) were male.…”

Section: Demographic Profilesupporting

confidence: 92%

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Assessment of Symptomatic Post Tuberculosis Patients by Spirometry and Chest X Ray

Pandey¹,

Agrawal²,

Agarwal³

et al. 2020

IJCMR

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Introduction: TB is an infectious disease caused by the bacillus Mycobacterium tuberculosis which typically affects the lungs. The disease is spread by the people who are sick with active pulmonary TB. Up to half of TB survivors have some form of persistent pulmonary symptom despite microbiologic cure. The aim of the study was to assess the symptomatic post tuberculosis patients by using spirometry and chest x ray. Material and methods: The study was conducted in the Department of Respiratory Medicine, Rohilkhand Medical College and Hospital after seeking clearance from the Institutional Ethical Committee. The aim of the study was to assess the symptomatic post tuberculosis patients by using spirometry and chest x ray. The study duration was from 1 st November 2018 to 31 st October 2019 and 100 patients were enrolled in the study. Data was collected from patients who presented with symptoms within 6 months of completing their treatment for tuberculosis. Results: All the patients (post tubercular) enrolled in the study had symptoms (in some form) even after full course of antitubercular treatment and bacteriological cure and among these breathlessness was the most common presenting symptom (96%) followed by cough (58%). Maximum patients had abnormal findings on chest examination (80%). Fibrosis followed by cavitary lesions were the most common findings on chest x ray in post tuberculosis patients. Maximum patients had restriction (56%) in their spirometry followed by mixed pattern (23%). Conclusion: In patients with restriction on spirometry and having symptom of breathlessness and cough, reassurance and pulmonary rehabilitation may play a major role in relieving their symptoms whereas in patients with mixed or obstructive pattern on spirometry, bronchodilator therapy along with pulmonary rehabilitation may be helpful in relieving their symptoms post tuberculosis treatment.

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Section: Demographic Profilesupporting

confidence: 92%

“…In the present study maximum number of patients were in the active age group i.e. 21-60 years (45% of patients in the age group of 41-60 years followed by 32% in 21…”

Section: Resultsmentioning

confidence: 51%

Assessment of Symptomatic Post Tuberculosis Patients by Spirometry and Chest X Ray

Pandey¹,

Agrawal²,

Agarwal³

et al. 2020

IJCMR

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“…Similarly, Ehrlich et al in a nationwide survey of 13 826 adults in South Africa, found that a history of pulmonary tuberculosis was a stronger predictor of COPD than tobacco smoking or biomass fuel smoke exposure. Ngahane et al studied the prevalence and predictors of lung functions impairment in a tuberculosis reference clinic in Cameroon. They reported lung function impairment in 45.4% of patients.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis associated chronic obstructive pulmonary disease

Sarkar

Srinivasa

Madabhavi

et al. 2017

Clinical Respiratory J

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“…A study in sub-Saharan Africa wherein 90% of participations were never smokers with normal baseline lung function also revealed that restrictive pattern was dominant in post-TB spirometric changes (15). …”

Section: Discussionmentioning

confidence: 99%

The Definition of Past Tuberculosis Affects the Magnitude of Association between Pulmonary Tuberculosis and Respiratory Dysfunction: Korea National Health and Nutrition Examination Survey, 2008–2012

Choi

Lee

et al. 2017

J Korean Med Sci

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Tuberculosis (TB) is associated with an increased risk of chronic lung impairment. The aim of this study was to compare the clinical characteristics and lung functions according to definition of past TB. We used the population-based, Korea National Health and Nutrition Examination Survey (KNHANES) (2008–2012) to analyze 13,522 subjects age 40 years or older who underwent spirometry and chest X-ray (CXR). Subjects with TB lesions on CXR (with or without a history of TB) were older, more likely to be male, ever smokers, and of low socioeconomic status than subjects with only a history of TB or without evidence of TB. Airflow obstruction (AFO) was associated with only a history of TB (odds ratio [OR] 1.53, 95% confidence interval [CI] 0.95–2.46), only TB lesion on CXR (OR 2.37, 95% CI 1.80–3.12), and both a history and TB lesions on CXR (OR 4.47, 95% CI 3.07–6.51) after adjustment for gender, age, body mass index, education, income, and smoking amount (P for trend < 0.001). Spirometric restriction was associated with only a history of TB (OR 1.29, 95% CI 0.80–2.08), only TB lesions on CXR (OR 2.03, 95% CI 1.49–2.76), and both a history and TB lesions on CXR (OR 2.65, 95% CI 1.74–4.05) after adjustment for the above variables (P for trend < 0.001). How to define past TB in population study affects the magnitude of association between past TB and respiratory dysfunction. Without considering TB lesions on CXR, the association between TB and respiratory dysfunction could be underestimated.

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Post-tuberculous lung function impairment in a tuberculosis reference clinic in Cameroon

Abstract: Post-tuberculous pulmonary function impairment is frequent in Douala. Sensitization of patient with symptoms of pulmonary TB for an earlier visit to healthcare facilities could reduce the impact of pTB on lung function of patients.

Cited by 35 publications

References 20 publications

Assessment of Symptomatic Post Tuberculosis Patients by Spirometry and Chest X Ray

Assessment of Symptomatic Post Tuberculosis Patients by Spirometry and Chest X Ray

Tuberculosis associated chronic obstructive pulmonary disease

The Definition of Past Tuberculosis Affects the Magnitude of Association between Pulmonary Tuberculosis and Respiratory Dysfunction: Korea National Health and Nutrition Examination Survey, 2008–2012

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