Post-Vaccination Symptomatic SARS-CoV-2 Infections are Minimal and Non-Serious: An Observational Multicenter Indian Cohort Study of 28342 Healthcare Workers

Vaishya, Raju; Sibal, Anupam; Malani, Arpita; Kar, Sujoy Kumar; K, Hari Prasad; Sv, Kiran; Reddy, Sangita; Kamineni, Shobana; Reddy, Suneeta; Reddy, Preetha Apollo; Redddy, Prathap Chandra

doi:10.2139/ssrn.3889352

Cited by 2 publications

References 18 publications

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Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Chandan

Khan

Deliwala

et al. 2021

Journal of Medical Virology

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Healthcare workers (HCWs) remain on the front line of the battle against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) infection and are among the highest groups at risk of infection during this raging pandemic. We conducted a systematic review and meta-analysis to assess the incidence of postvaccination SARS-CoV-2 infection among vaccinated HCWs. We searched multiple databases from inception through August 2021 to identify studies that reported on the incidence of postvaccination SARS-CoV-2 infection among HCWs. Meta-analysis was performed to determine pooled proportions of COVID-19 infection in partially/fully vaccinated as well as unvaccinated individuals. Eighteen studies with 228 873 HCWs were included in the final analysis. The total number of partially vaccinated, fully vaccinated, and unvaccinated HCWs were 132 922, 155 673, and 17 505, respectively. Overall pooled proportion of COVID-19 infections among partially/ fully vaccinated and unvaccinated HCWs was 2.1% (95% confidence interval [CI]1.2-3.5). Among partially vaccinated, fully vaccinated and unvaccinated HCWs, pooled proportion of COVID-19 infections was 2.3% (CI 1.2-4.4), 1.3% (95% CI 0.6-2.9), and 10.1% (95% CI 4.5-19.5), respectively. Our analysis shows the risk of COVID-19 infection in both partially and fully vaccinated HCWs remains exceedingly low when compared to unvaccinated individuals. There remains an urgent need for all frontline HCWs to be vaccinated against SARS-CoV-2 infection.

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Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Chandan

Khan

Deliwala

et al. 2021

Journal of Medical Virology

View full text Add to dashboard Cite

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Postvaccination SARS-CoV-2 infection among healthcare workers – A Systematic Review and meta-analysis

Chandan

Khan

Deliwala

et al. 2021

Preprint

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INTRODUCTION: Healthcare workers (HCWs) remain on the front line of the battle against SARS-CoV-2 and COVID-19 infection, and are among the highest groups at risk of infection during this raging pandemic. We conducted a systematic review and meta-analysis to assess incidence of postvaccination SARS-CoV-2 infection among vaccinated HCWs. METHODS: We searched multiple databases from inception through August 2021 to identify studies that reported on incidence of postvaccination SARS-CoV-2 infection among HCWs. Meta-analysis was performed to determine pooled proportions of COVID-19 infection in partially and fully vaccinated individuals. RESULTS: Eighteen studies with 228,873 HCWs were included in the final analysis. Total number of partially vaccinated, fully vaccinated, and unvaccinated HCWs were 132,922, 155,673 and 17505, respectively. Overall pooled proportion of COVID-19 infections among partially/fully vaccinated and unvaccinated HCWs was 2.1% (95% CI 1.2-3.5). Among partially vaccinated, fully vaccinated and unvaccinated HCWs, pooled proportion of COVID-19 infections was 3.7% (95% CI 1.8-7.3), 1.3% (95% CI 0.6-2.9), and 10.1% (95% CI 4.5-19.5), respectively. DISCUSSION: Our analysis shows the risk of COVID-19 infection in both partially and fully vaccinated HCWs remains exceedingly low when compared to unvaccinated individuals. There remains an urgent need for all frontline HCWs to be vaccinated against SARS-CoV-2 infection.

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Post-Vaccination Symptomatic SARS-CoV-2 Infections are Minimal and Non-Serious: An Observational Multicenter Indian Cohort Study of 28342 Healthcare Workers

Cited by 2 publications

References 18 publications

Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Postvaccination SARS-CoV-2 infection among healthcare workers – A Systematic Review and meta-analysis

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