Postarthroplasty histiocytic lymphadenopathy in gynecologic oncology patients: A benign reactive process that clinically may be mistaken for cancer

Zaloudek, Charles; Treseler, Patrick A.; Powell, C. Bethan

doi:10.1002/(sici)1097-0142(19960815)78:4<834::aid-cncr21>3.0.co;2-v

Cited by 13 publications

(2 citation statements)

References 47 publications

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“…Multiple studies have demonstrated that, under transmission electron microscopy, these vesicles are membrane bound and filled with needle or granular-shaped particles, consistent with polyethylene. 4,7,19,22 Larger particles were variably admixed. Particles larger than 3 to 5 µm were often associated with foreign body giant cell reaction.…”

Section: Discussionmentioning

confidence: 99%

Histological Analysis of Early Osteolysis in Total Ankle Arthroplasty

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Histological Analysis of Early Osteolysis in Total Ankle Arthroplasty

et al. 2016

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“…The pelvic nodes draining these areas are subject to develop a distinctive form of histiocytic lymphadenopathy. 1,2 The recipient nodes become enlarged and effaced by sheets of histiocytes with abundant pale granular gray-blue cytoplasm (Figure 1). Black needles and flakes are present in the histiocytes, which represent cobalt-chromium debris fragments (Figure 2).…”

Section: Histiocytic Lymphadenopathy Secondary To Metallosis Following Hip Replacementmentioning

confidence: 99%

Histiocytic Lymphadenopathy Secondary to Metallosis Following Hip Replacement

Cerilli

2006

Int J Surg Pathol

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Exaggerated pigmented granulomatous reaction to the artificial joint implant mimics metastatic melanoma

Wei

Davenport

Chang

et al. 2004

Diagnostic Cytopathology

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Total joint replacement is a common orthopedic procedure. An artificial joint implant may fail due to mechanical mishap and a granulomatous reaction can be induced by the artificial joint debris after the mechanical failure. We report a case of an exaggerated pigmented granulomatous tissue response to metallic artificial joint implant debris in a 72-yr-old male that was mistaken for metastatic melanoma. The mass was soft, pigmented, ill-defined, and located in the right inguinal region. Fine-needle aspiration revealed numerous black-pigment laden cells. The cellular features were frequently obscured by the heavy pigmentation. Occasional cells exhibited atypia and prominent nucleoli. There were also abundant extracellular irregular small black particles dispersed in the background. The diagnosis of melanoma involving a lymph node was made. Since there was no prior history of melanoma, it was presumed that this represented metastatic melanoma from an unknown primary. A subsequent exploration of the groin was performed with the intent to resect the disease. At exploration, the mass was found to be contiguous with the hip joint and the frozen section of the mass revealed no evidence of melanoma. The final tissue diagnosis confirmed the frozen section report and showed a granulomatous reaction. This report underscores the diagnostic dilemma associated with the exaggerated pigmented granulomatous reaction due to an artificial prosthesis.

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Postarthroplasty histiocytic lymphadenopathy in gynecologic oncology patients: A benign reactive process that clinically may be mistaken for cancer

Abstract: BACKGROUND.A distinctive histiocytosis occurs in the regional draining lymph

Cited by 13 publications

References 47 publications

Histological Analysis of Early Osteolysis in Total Ankle Arthroplasty

Histological Analysis of Early Osteolysis in Total Ankle Arthroplasty

Histiocytic Lymphadenopathy Secondary to Metallosis Following Hip Replacement

Exaggerated pigmented granulomatous reaction to the artificial joint implant mimics metastatic melanoma

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