Postbiotics as novel health-promoting ingredients in functional foods

Rad, Aziz Homayouni; Kafil, Hossein Samadi; Zavoshti, Hamideh Fathi; Abbasi, Amin

doi:10.15171/hpp.2020.02

Cited by 68 publications

(17 citation statements)

References 11 publications

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“…Postbiotic is a relatively new term to classify the metabolites, cell components derived from a probiotic that can influence the microbiome composition [19,52]. They are bioactive, soluble, nonliving microbial cell products that possess several practical advantages over the probiotic itself, as they show biological activity in the nonviable state and are easier to formulate with favorable physicochemical properties [53]. LactoSporin shows antimicrobial activity at acidic pH conditions.…”

Section: Discussionmentioning

confidence: 99%

Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Efficacy, Tolerability and Safety

Majeed

Nagabhushanam

et al. 2020

Cosmetics

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Acne vulgaris is a common skin disorder of pilosebaceous units. The therapy for mild-to-moderate acne includes topical antibiotics, benzoyl peroxide and retinoids. In this open-label, randomized monocentric study, we compared the efficacy of LactoSporin® 2% w/w cream with benzoyl peroxide in 64 male and female subjects with mild-to-moderate acne for three weeks. The efficacy parameters were evaluated based on the dermatologist visual assessment and instrumental measurements using Sebumeter® MPA580, Antera 3DTM and VISIA CR 2.2 and subject self-assessment questionnaires. Adverse events were recorded throughout the study period. In order to understand the mechanism of action and properties of LactoSporin, the pH stability, thermostability, antimicrobial activity and 5-alpha reductase activity were evaluated in vitro. A significant improvement was observed in the dermatological assessment of closed comedones (p < 0.0001), open comedones (p = 0.0069) and papules count (p < 0.0001) in comparison to the baseline in both LactoSporin and benzoyl peroxide groups. The antera analysis showed significant improvement in redness (p < 0.0001) and elevation (p < 0.0001) (small and medium) in both the treatment groups. The sebumeter analysis showed a significant decrease in sebaceous secretion (p < 0.0001) for LactoSporin, which resulted in reduced oiliness, pimples, acne spots and redness around the acne spot. The product was found to be safe without any irritancy. LactoSporin was stable at an acidic pH and temperature range of 70 to 90 °C, with antimicrobial activity against various pathogenic bacteria, including Cutibacterium acnes. It was also a potent inhibitor of 5-alpha reductase activity. Thus, it can be concluded that the efficacy of LactoSporin is equivalent to benzoyl peroxide in the treatment of mild-to-moderate acne lesions and better than benzoyl peroxide for reducing the sebaceous secretion and oily, greasy nature of the skin, implying its efficacy in other sebohorriec conditions.

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Section: Discussionmentioning

confidence: 99%

Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Efficacy, Tolerability and Safety

Majeed

Nagabhushanam

et al. 2020

Cosmetics

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“…Along with user awareness, to optimize the positive effects of probiotics on human health, food products containing postbiotic compounds have been introduced [ 157 ]. Postbiotics are biotherapeutic products derived from inactivated probiotic strains, or their metabolic products, or both, following a fermentation process and which are used to maintain the integrity of the intestinal barrier and promote the health of patients at high risk of disease [ 158 ].…”

Section: Prebiotics Probiotics Paraprobiotics Postbiotics and Synbiotics: Challenges And Controversiesmentioning

confidence: 99%

“…Postbiotics are beneficial in terms of safety, biological properties, absorption, transport, metabolism, distribution, excretion, proper signaling to various host organs and tissues, and for pharmaceuticals, as they do not include any risk of translocation from the intestinal lumen into the blood, compared to the living probiotics [ 75 ]. Postbiotics strengthen host endogenous probiotics in the intestinal microbial ecosystem [ 159 , 160 , 161 ] to prevent disease, strengthen the immune system and as complementary therapeutic alternatives [ 157 ].…”

Section: Prebiotics Probiotics Paraprobiotics Postbiotics and Synbiotics: Challenges And Controversiesmentioning

confidence: 99%

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Ailioaie

Litscher

2021

IJMS

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In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut–lung–brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body.

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“…Modifications in microbiota structure occur commonly due to exposure to different environmental factors, including toxins, drugs, diet and existing pathogens. Of note, intestinal pathogens contribute to causing microbial dysbiosis due to high potency factors 15 16…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota and obesity: an overview of microbiota to microbial-based therapies

Baghi

Abbasi

Leylabadlo

et al. 2022

Postgraduate Medical Journal

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The increasing prevalence of obesity and overweight is a significant public concern throughout the world. Obesity is a complex disorder involving an excessive amount of body fat. It is not just a cosmetic concern. It is a medical challenge that increases the risk of other diseases and health circumstances, such as diabetes, heart disease, high blood pressure and certain cancers. Environmental and genetic factors are involved in obesity as a significant metabolic disorder along with diabetes. Gut microbiota (GM) has a high potential for energy harvesting from the diet. In the current review, we aim to consider the role of GM, gut dysbiosis and significant therapies to treat obesity. Dietary modifications, probiotics, prebiotics, synbiotics compounds, using faecal microbiota transplant, and other microbial-based therapies are the strategies to intervene in obesity reducing improvement. Each of these factors serves through various mechanisms including a variety of receptors and compounds to control body weight. Trial and animal investigations have indicated that GM can affect both sides of the energy-balancing equation; first, as an influencing factor for energy utilisation from the diet and also as an influencing factor that regulates the host genes and energy storage and expenditure. All the investigated articles declare the clear and inevitable role of GM in obesity. Overall, obesity and obesity-relevant metabolic disorders are characterised by specific modifications in the human microbiota’s composition and functions. The emerging therapeutic methods display positive and promising effects; however, further research must be done to update and complete existing knowledge.

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Postbiotics as novel health-promoting ingredients in functional foods

Cited by 68 publications

References 11 publications

Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Efficacy, Tolerability and Safety

Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Efficacy, Tolerability and Safety

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Gut microbiota and obesity: an overview of microbiota to microbial-based therapies

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