Postbiotics as potential new therapeutic agents for metabolic disorders management

Bourebaba, Yasmina; Marycz, Krzysztof; Mularczyk, Malwina; Bourebaba, Lynda

doi:10.1016/j.biopha.2022.113138

Cited by 78 publications

(39 citation statements)

References 208 publications

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“…Probiotics are live bacteria that benefit the host by producing useful physiologically bioactive compounds. These compounds have been reported to have immunomodulatory, anti-carcinogenic, anti-aging, and anti-microbial effects, but their utilities are currently limited by a lack of knowledge of their molecular mechanisms, strain-specific behaviors, and safeties ( Bourebaba et al, 2022 ; Rodríguez-Pastén et al, 2022 ). To address these limitations, studies have recently focused on postbiotic molecules, which are defined as metabolic products secreted by probiotics in cell-free supernatants ( Nataraj et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Shin

Truong

Lee³

et al. 2023

Current Research in Food Science

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Section: Introductionmentioning

confidence: 99%

Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Shin

Truong

Lee³

et al. 2023

Current Research in Food Science

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“…These substances have natural biological activities that have been extensively studied in recent years. Immunomodulatory, anti-inflammatory, anticarcinogenic, antibacterial, antiviral, anticancer, antioxidant, antidiabetic, obesity-reducing, antihyperhypertensive and antiallergic efficacies constitute the most important biological roles of postbiotics [ 9 , 10 ]. In terms of safety, it has been confirmed that postbiotics, as potential substitutes, may be even superior to their parental living cells.…”

Section: Introductionmentioning

confidence: 99%

Protective and Therapeutic Capacities of Lactic Acid Bacteria Postmetabolites against Koi Herpesvirus Infection In Vitro

Vilhelmova-Ilieva

Danova

Petrova

et al. 2023

Life

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Background: The accumulation of data on beneficial biological effects of probiotics and their metabolic products favors their potential use in the prevention and treatment of various malaises. Methods: Nine postmetabolites from Lactic acid bacteria (LAB) of human or dairy origin and their antiviral activity were studied using the cytopathic effect inhibition test. The virucidal capacity, their influence on the adsorption stage of Koi herpes virus (KHV) and their preventive role against subsequent viral challenge on intact Common carp brain (CCB) cells were also determined by titration assay. Residual viral infectivity in postmetabolites-treated samples was compared to mock-treated controls and Δlgs were calculated. Results: When administered during KHV replication, the microbial products isolated from Lactiplantibacillus plantarum showed remarkable activity with a selectivity index (SI) between 26.5 and 221.4, as those effects were dependent on the sample-virus incubation time. Postmetabolites from Lactobacillus gasseri and Lactiplantibacillus plantarum also demonstrated significant inhibition of KHV replication with SI of 24 and 16, respectively. The bioactive metabolites isolated from Limosilactobacillus fermentum had a minor effect on the viral replicative cycle. Compounds, produced during the fermentation by lactobacilli, grown on different nutritive media and collected at different time points, significantly inhibited extracellular KHV virions. All investigated postmetabolites remarkably blocked KHV attachment to the host cell (CCB), leading to a drop in viral titers by Δlg = 4.25–5.25, and exerted protective effects on CCB cells before they were subjected to viral infection. Conclusions: Our results open new horizons and promote LAB and their postbiotic products to be used in the prophylaxis and therapy of viral infections.

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“…These compounds have immunomodulatory, anti-carcinogenic, anti-aging, and antimicrobial effects in hosts. However, the use of these compounds is currently limited by a lack of knowledge of their molecular mechanisms, strain specific behaviors, and safety ( Bourebaba et al, 2022 ). To address these limitations, recent studies have focused on elucidating microbial metabolism and discovering postbiotic molecules, which are defined as metabolic products secreted by probiotics in cell-free supernatants ( Nataraj et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Red ginseng dietary fiber promotes probiotic properties of Lactiplantibacillus plantarum and alters bacterial metabolism

et al. 2023

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Korean red ginseng has been widely used as an herbal medicine. Red ginseng dietary fiber (RGDF) is a residue of the processed ginseng product but still contains bioactive constituents that can be applied as prebiotics. In this study, we evaluated changes on fermentation profiles and probiotic properties of strains that belong to family Lactobacillaceae with RGDF supplementation. Metabolomic analyses were performed to understand specific mechanisms on the metabolic alteration by RGDF and to discover novel bioactive compounds secreted by the RGDF-supplemented probiotic strain. RGDF supplementation promoted short-chain fatty acid (SCFA) production, carbon source utilization, and gut epithelial adhesion of Lactiplantibacillus plantarum and inhibited attachment of enteropathogens. Intracellular and extracellular metabolome analyses revealed that RGDF induced metabolic alteration, especially associated with central carbon metabolism, and produced RGDF-specific metabolites secreted by L. plantarum, respectively. Specifically, L. plantarum showed decreases in intracellular metabolites of oleic acid, nicotinic acid, uracil, and glyceric acid, while extracellular secretion of several metabolites including oleic acid, 2-hydroxybutanoic acid, hexanol, and butyl acetate increased. RGDF supplementation had distinct effects on L. plantarum metabolism compared with fructooligosaccharide supplementation. These findings present potential applications of RGDF as prebiotics and bioactive compounds produced by RGDF-supplemented L. plantarum as novel postbiotic metabolites for human disease prevention and treatment.

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Postbiotics as potential new therapeutic agents for metabolic disorders management

Cited by 78 publications

References 208 publications

Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Protective and Therapeutic Capacities of Lactic Acid Bacteria Postmetabolites against Koi Herpesvirus Infection In Vitro

Red ginseng dietary fiber promotes probiotic properties of Lactiplantibacillus plantarum and alters bacterial metabolism

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