2019
DOI: 10.1007/s11682-019-00067-x
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Postchemotherapy hippocampal functional connectivity patterns in patients with breast cancer: a longitudinal resting state functional MR imaging study

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Cited by 28 publications
(36 citation statements)
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“…The insula is believed to be involved in emotion and consciousness. A previous study (Feng et al 2019) reported that patients treated with chemotherapy showed persistent anxiety and depression symptoms over time and that psychological symptom score changes were significantly positively associated with FC changes between the left hippocampus and left insula. We hypothesized that the increased sFC between the left DLPFC and right insula may be a mechanism of selfregulating negative emotion in lung cancer patients.…”
Section: Discussionmentioning
confidence: 88%
See 1 more Smart Citation
“…The insula is believed to be involved in emotion and consciousness. A previous study (Feng et al 2019) reported that patients treated with chemotherapy showed persistent anxiety and depression symptoms over time and that psychological symptom score changes were significantly positively associated with FC changes between the left hippocampus and left insula. We hypothesized that the increased sFC between the left DLPFC and right insula may be a mechanism of selfregulating negative emotion in lung cancer patients.…”
Section: Discussionmentioning
confidence: 88%
“…Second, although the present study employed a longitudinal experimental design, follow-up data were collected only for patients in the lung cancer group and not for healthy controls. Previous studies (Feng et al 2019;Pergolizzi et al 2019) have provided evidence that cancer patients after chemotherapy exhibit FC changes during short-term follow-up (3-6 months) and have no significant difference in healthy controls. Nevertheless, all enrolled subjects should be strictly followed in subsequent longitudinal Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Decreased functional connectivity of DMN was reported particularly in the medial prefrontal cortex, posterior cingulate cortex and the medial temporal cortex [20,15]. Our previous study found abnormal hippocampal connectivity in superior/middle temporal gyrus/insula and frontal gyrus, most are parts of the RSNs [21]. These altered functional connectivities were involved in the regulation of executive, memory and emotion, supporting chemotherapy induced widespread cognitive networks disruption.…”
Section: Introductionmentioning
confidence: 82%
“…Bergouignan et al also observed hippocampal atrophy (8% volume reduction) and impairments in episodic memory in breast cancer survivors, 18-36 months after treatment completion (surgery, chemotherapy, radiation) relative to controls 32 . Functional neuroimaging studies of breast cancer survivors revealed altered hippocampal connectivity 5-6 months after chemotherapy treatment using resting-state functional magnetic resonance imaging (Rs-fMRI), which correlated with executive function, planning, and working memory impairments 33,34 .…”
Section: Clinical Neuroimaging and Cognitive Studiesmentioning
confidence: 99%