Posterior fossa xanthogranuloma

Vaquero, Jesús; Leunda, Guillermo; Cabezudo, J.M.; Juan, M. De; Herrero, J.J. Espejo; Bravo, G.

doi:10.3171/jns.1979.51.5.0718

Cited by 32 publications

(8 citation statements)

References 14 publications

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“…XG were firstly described by Blumer in 1900 2 they have been found incidentally in 1.6 to 7% of the cases in autopsy series 19 . XG are more frequent in the lateral ventricles where they usually remain asymptomatic because they are too small to obstruct the CSF flow.…”

Section: Discussionmentioning

confidence: 91%

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Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

et al. 2005

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ResumenEl xantogranuloma del plexo coroideo es un tumor benigno de etiología desconocida que raramente produce síntomas. Su comportamiento en los estudios de resonancia magnética se ha descrito en pocas ocasiones y no está bien definido. Presentamos un nuevo caso de xantogranuloma del tercer ventriculo con caraterísti-cas atípicas en los estudios de CT y RM craneal en un paciente de 47 años y una clínica de 2 meses de evolución de alteración de la marcha y deterioro cognitivo. Igualmente, se revisa la literatura existente respecto a la presentación clínica y radiológica de estos tumores.PALABRAS CLAVE: Xantogranuloma. Tumor de tercer ventrículo. RM Introduction XG are benign tumours typically composed of large foam-filled cells with clusters of lymphocytes and macrophages associated to cholesterol clefts. XG rarely cause neurological dysfunction 3,13,15 . With few exceptions, they constitute incidental autopsy findings almost always restricted to the choroid plexus of the lateral ventricles 21 . Obstruction of the ventricular system has been reported infrequently. Etiology is still debatable 17 . We report a new case of symptomatic XG of the third ventricle studied with CT and MRI and showing some particular histopathological and neuroradiological features. Case reportA 47-year-old man was admitted with a 2-month history of gait instability and urinary disturbances, consisting in occasional loss of sphincterian control and short-term memory deficits. The symptoms had developed insidiously and the patient did not suffer headache, vomiting or loss of visual acuity.Physical and routine laboratory examinations, including serum cholesterol determinations, were normal. Neurological examination revealed disturbance of recent memory and cognitive impairment. Fundoscopy was normal. He scored 24/30 on minimental test. Short stepped gait and intentional tremor were also observed.Cranial CT scan showed a 2x2x1 cm oval shaped lesion located in area of the third ventricle obstructing the foramina of Monro and causing biventricular hydrocephalus. The lesion was heterogeneous appearing partly hypodense and hyperdense, with hyperdense areas corresponding to calcification. Following contrast injection the lesion showed partial enhancement. There was associated edema in the basal ganglia of the left cerebral hemisphere ( Figure 1).Cranial MRI revealed the lesion in the region of third ventricle and hypothalamic area. It was located mainly extraventricularly, spreading between the fornices, oc- cluding both foramina of Monro and causing bilateral hydrocephalus. It was heterogeneous in appearance being isointense in pT1 sequences and hyperintense in pT2 images, showing haemosiderin deposits and calcification. Important hyperintensity extending into the left basal ganglia region suggestive of edema was also observed. Following gadolinium administration it showed partial enhancement ( Figure 2).The patient was operated through a transcallosal approach. The left foramen of Monro appeared deformated by a brown yellowish subependymal l...

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Section: Discussionmentioning

confidence: 91%

“…Among the sixteen cases of XG located in the third ventricle reported up to date 1,6,8,[10][11][12][13][14][15]17,18,20 only four were studied with MRI 17,18,20 . XG of the fourth ventricle are exceptional 19 .…”

Section: Discussionmentioning

confidence: 99%

Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

et al. 2005

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“…Occasionally, large XGs of the choroid plexus requir ing surgical intervention for symptoms related to a mass effect or obstructive hydrocephalus in both children [16][17][18][19] and adults [20][21][22][23][24][25][26][27][28][29][30][31][32][33] have been reported. These 'chor oid plexus XGs' are considered pseudoneoplastic [9,14], and can be distinguished from JXG by their histologic appearance, which consists chiefly of foamy histiocytes, cholesterol crystals, and eventually, giant cells and inflam matory infiltrates [9], Intracranial dural [34][35][36], spinal dural [37], and dif fuse leptomeningeal involvement [38] with XGs have been reported. Dural based forms generally occur in indi viduals with Langerhans cell histiocytosis, including Hand-Schuller-Christian (HSC) or Weber-Christian dis ease, and are generally distinguishable from JXG by his tological, immunohistochemical and electron microscop ic features [9,10,34,35,39], However, three recent reports of dural-based lesions more characteristic of JXG in children without HSC or Weber-Christian disease are unusual and noteworthy.…”

Section: Discussionmentioning

confidence: 99%

Solitary Intracerebral Juvenile Xanthogranuloma

Schultz¹,

Petronio²,

Narad³

et al. 1997

Pediatr Neurosurg

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A case of an intracerebral juvenile xanthogranuloma (JXG) producing complex-partial seizures in a 13-year-old boy is presented. Although the child had no history of JXGs or a systemic histiocytic proliferative disorder, the histopathological and immunocytochemical studies of this lesion were identical to that of a cutaneous JXG. This represents the first description of an isolated intracerebral JXG. On extensive review of the literature, this case comprises only the second reported intracranial lesion and the fourth CNS lesion in a child without cutaneous manifestations of JXG. In contrast to cerebral xanthogranulomas of adulthood, all reported cases of isolated CNS JXG presented with focal symptoms referable to the neuroanatomic localization of the lesion. In this limited series, the magnetic resonance imaging appearance was predictable and consistent, although spinal and intracranial lesions differ with respect to their enhancement with paramagnetic contrast media. While complete surgical excision, if feasible, has been the most utilized form of therapy for symptomatic or progressive lesions, external beam irradiation and cytotoxic chemotherapy have been utilized for unresectable or recurrent disease. Given their rare occurrence and uncertain natural history, it remains unclear whether these solitary CNS lesions represent a distinct clinical entity with a potentially more aggressive clinical course or merely a variant of the systemic non-Langerhans cell histiocytoses.

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Section: Discussionmentioning

confidence: 99%

Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

Miranda¹,

Lobato²,

Ricoy³

et al. 2005

Neurocirugía

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ResumenEl xantogranuloma del plexo coroideo es un tumor benigno de etiología desconocida que raramente produce síntomas. Su comportamiento en los estudios de resonancia magnética se ha descrito en pocas ocasiones y no está bien definido. Presentamos un nuevo caso de xantogranuloma del tercer ventriculo con caraterísti-cas atípicas en los estudios de CT y RM craneal en un paciente de 47 años y una clínica de 2 meses de evolución de alteración de la marcha y deterioro cognitivo. Igualmente, se revisa la literatura existente respecto a la presentación clínica y radiológica de estos tumores. . We report a new case of symptomatic XG of the third ventricle studied with CT and MRI and showing some particular histopathological and neuroradiological features. Case reportA 47-year-old man was admitted with a 2-month history of gait instability and urinary disturbances, consisting in occasional loss of sphincterian control and short-term memory deficits. The symptoms had developed insidiously and the patient did not suffer headache, vomiting or loss of visual acuity.Physical and routine laboratory examinations, including serum cholesterol determinations, were normal. Neurological examination revealed disturbance of recent memory and cognitive impairment. Fundoscopy was normal. He scored 24/30 on minimental test. Short stepped gait and intentional tremor were also observed.Cranial CT scan showed a 2x2x1 cm oval shaped lesion located in area of the third ventricle obstructing the foramina of Monro and causing biventricular hydrocephalus. The lesion was heterogeneous appearing partly hypodense and hyperdense, with hyperdense areas corresponding to calcification. Following contrast injection the lesion showed partial enhancement. There was associated edema in the basal ganglia of the left cerebral hemisphere ( Figure 1).Cranial MRI revealed the lesion in the region of third ventricle and hypothalamic area. It was located mainly extraventricularly, spreading between the fornices, oc- cluding both foramina of Monro and causing bilateral hydrocephalus. It was heterogeneous in appearance being isointense in pT1 sequences and hyperintense in pT2 images, showing haemosiderin deposits and calcification. Important hyperintensity extending into the left basal ganglia region suggestive of edema was also observed. Following gadolinium administration it showed partial enhancement ( Figure 2).The patient was operated through a transcallosal approach. The left foramen of Monro appeared deformated by a brown yellowish subependymal lesion adhered to the body of the left fornix. Total excision preserving both fornices was achieved. Histopathological examination revealed a lesion composed of foamy cells in relation to vascular lines corresponding to choroids plexus showing changes secondary to haemorrhage and fibrosis which would explain the absence of the typical epithelial covering of the choroid plexus. The histological diagnosis was xanthogranuloma ( Figure 3).Postoperative MRI control showed disappearance of perilesional edema and mass ef...

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Posterior fossa xanthogranuloma

Cited by 32 publications

References 14 publications

Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

Solitary Intracerebral Juvenile Xanthogranuloma

Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

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