Postexercise Proteinuria in Humans

Poortmans, Jacques

doi:10.1001/jama.1985.03350260088032

Cited by 90 publications

(68 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exercise has often been associated with increased proteinuria, but this is generally associated with exhaustive bouts of exercise (19,20,48,49). Our data clearly indicate that our exercise protocol was not sufficiently intense enough to elicit such an increase.…”

Section: Discussionmentioning

confidence: 63%

Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats

Emter

McCune²,

Sparagna³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

. Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. Am J Physiol Heart Circ Physiol 289: H2030 -H2038, 2005. First published July 1, 2005; doi:10.1152/ajpheart.00526.2005.-Data regarding the effectiveness of chronic exercise training in improving survival in patients with congestive heart failure (CHF) are inconclusive. Therefore, we conducted a study to determine the effect of exercise training on survival in a well-defined animal model of heart failure (HF), using the lean male spontaneously hypertensive HF (SHHF) rat. In this model, animals typically present with decompensated, dilated HF between ϳ18 and 23 mo of age. SHHF rats were assigned to sedentary or exercise-trained groups at 9 and 16 mo of age. Exercise training consisted of 6 mo of low-intensity treadmill running. Exercise training delayed the onset of overt HF and improved survival (P Ͻ 0.01), independent of any effects on the hypertensive status of the rats. Training delayed the myosin heavy chain (MyHC) isoform shift from ␣-to ␤-MyHC that was seen in sedentary animals that developed HF. Exercise was associated with a concurrent increase in cardiomyocyte length (Ϸ6%), width, and area and prevented the increase in the length-to-width ratio seen in sedentary animals in HF. The increases in proteinuria, plasma atrial natriuretic peptide, and serum leptin levels observed in rats with HF were suppressed by low-intensity exercise training. No significant alterations in sarco (endo)plasmic reticulum Ca 2ϩ ATPase, phospholamban, or Na ϩ / Ca 2ϩ exchanger protein expression were found in response to training. Our results indicate that 6 mo of low-intensity exercise training delays the onset of decompensated HF and improves survival in the male SHHF rat. Similarly, exercise intervention prevented or suppressed alterations in several key variables that normally occur with the development of overt CHF. These data support the idea that exercise may be a useful and inexpensive intervention in the treatment of HF. myosin heavy chain; proteinuria; cardiomyocyte morphology; atrial natriuretic peptide; leptin HEART DISEASE is a leading cause of death among men and women in Western industrialized societies. Cardiovascular disease (CVD) currently affects over 70 million Americans, 65 million of which are estimated to have high blood pressure and nearly 5 million are diagnosed with congestive heart failure (CHF) (2). With the diagnosis of CHF, life expectancy decreases dramatically and chances of survival decrease with 70 -80% of patients dying within 8 yr (2). Although chronic exercise training has clearly been shown to be beneficial in attenuating risk factors for CVD, including high blood pressure and cholesterol levels, insulin resistance, and obesity (9,14,53,58), the utility of exercise as a clinical intervention for patients with developing CHF is less clear. Currently, there is a lack of clarity regarding the efficacy of chronic exercise training as a treatment and in reducing mortali...

show abstract

Section: Discussionmentioning

confidence: 63%

Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats

Emter

McCune²,

Sparagna³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…shows that the decrease of sodium and water excretion during strenuous exercise in spite of an unchanged GFR may be explained by high production of aldosterone and by the deviation of blood from the kidneys to other organs during exercise (11,17). Therefore, the model used in the present study does not discriminate between the direct and indirect effects of endurance training on renal sodium reabsorption.…”

mentioning

confidence: 82%

“…Studies on humans using PAH clearance have demonstrated a decrease in renal plasma flow after physical exercise which was related to exercise intensity (16,17). An explanation for this reduced flow could be the intrarenal blood flow distribution, leading to a drop in the rate of renal PAH extraction during exercise (17).…”

mentioning

confidence: 99%

Effect of strenuous maternal exercise before and during pregnancy on rat progeny renal function

Oliveira

Fileto

Melis

2004

Braz J Med Biol Res

View full text Add to dashboard Cite

The effects of strenuous exercise before and during pregnancy on the renal function and morphological alterations of the progeny were determined in a study on female Wistar rats. This research was done based on a previous study carried out in our laboratory, which showed morphological alterations in rats submitted to this kind of exercise. As the form is related to the function, the physiological relevance of submitting a pregnant female to a high-intensity exercise training regimen could be explained by the fact that morphological alterations can influence kidney function. The animals were assigned to one of two groups: control animals that did not exercise during pregnancy and trained animals that swam for 120 min 5 days a week for 8 weeks before pregnancy and daily for 60 min over a period of 8 weeks starting on the second day of pregnancy. Seven rats of each group were analyzed for morphological alterations and for renal function. The progeny of the rats used for morphological evaluation were born by cesarean section and the progeny of the animals used to evaluate renal function were born normally. The progeny were two months old when renal function was evaluated. Fertility and morbidity were the same for both groups. Strenuous maternal exercise had no significant influence on glomerular filtration rate (GFR) but renal plasma flow was lower in the progeny of the trained group (mean ± SD, 16.65 ± 3.77 ml min -1 kg -1 ) compared to the progeny of the control group (33.42 ± 2.56 ml min -1 kg -1 ). Antidiuretic and antinatriuretic effects on the progeny of the trained group were observed, since urine flow as percentage of GFR and the fraction of urinary sodium excretion were lower in this group (1.38 ± 0.10 and 0.60 ± 0.04%, respectively) compared to the progeny of the control group (2.36 ± 0.11 and 1.55 ± 0.20%, respectively). Moreover, in this exercise program, fetuses from trained animals were small-sized (2.45 ± 0.19 vs 4.66 ± 2.45 g for control animals) and showed lower differentiation compared to fetuses from the control group. These effects were probably caused by caloric restriction, hypoxia and reduction of umbilical cord length.

show abstract

“…Post-exercise proteinuria has been found in various sport disciplines but the highest level has been noticed after swimming training [6,7]. Proteinuria depends on the type of exercise and its intensity [3,8,9]. Among several proteins existing in urine, measured after the training, albumin was notably on the highest level.…”

Section: Materials and Methods Subjectsmentioning

confidence: 99%

“…Kidneys play a key role in the development of the post-exercise proteinuria [2]. An increase in the proteinuria during an intense physical exercise is caused by penetration of the plasma proteins into renal tubules [3]. Proteins, present in the urine after an exercise on SAGI may provide valuable information about the process of adaptation to the physical exercise.…”

Section: Introductionmentioning

confidence: 99%

Post-exercise proteinuria in the cadets trained on Special Aerial Gymnastics Instruments

Wochyński¹,

Sobiech²

2015

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives: Assessment of the effect of training on Special Aerial Gymnastics Instruments (SAGI) on the urine β-2-microglobulin (β-2M), albumin (ALB), total protein (TP), N-acetyl-β-D-glucosaminidase EC.3.2.1.30 (NAG), expressed as creatinine (Cr) and on the physical fitness of the examined cadets in comparison with the control group. Material and Methods: The study involved 55 cadets aged 20, divided into group A (N = 41) trained on SAGI, and group B (N = 14) -a control group. The urine was collected twice: before the training (BT) and after the training (AT) at the start (training I), during (training II), and after completion of the training program (training III). Urine proteins were assayed with commercially available kits. Results: In group A, results obtained in trainings I, II and III showed a statistically significant increase in β-2M/Cr, NAG/Cr, TP/Cr, ALB/Cr indices in AT compared with the baseline BT values. Similarly in group B, a statistically significant increase in β-2M/Cr, NAG/Cr (trainings I, II), TP/Cr, AT compared with the baseline BT values in trainings I, II, and III was noted. Comparison of both groups showed a higher value of the post-exercise proteinuria in group B than in group A. In group A, a significant correlation between TP/Cr vs. ALB/Cr, NAG/Cr vs. TP/Cr, β-2M/Cr vs. TP/Cr, i.e., r = 0.62 at p < 0.001; r = 0.33 at p = 0.03; r = 0.60 at p < 0.001, and r = 0.52 at p < 0.001, respectively, was observed in group A, training III, AT. Conclusions: Assayed urine proteins depend on the intensity of physical exercise, the type of exercise, and the level of physical fitness.

show abstract

Postexercise Proteinuria in Humans

Cited by 90 publications

References 19 publications

Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats

Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats

Effect of strenuous maternal exercise before and during pregnancy on rat progeny renal function

Post-exercise proteinuria in the cadets trained on Special Aerial Gymnastics Instruments

Contact Info

Product

Resources

About