Postinfectious bronchiolitis obliterans masked by misdiagnosis as asthma

Onay, Zeynep Reyhan; Gürsoy, Tuğba Ramaslı; Aslan, Ayşe Tana; Eyüboğlu, Tuğba Şişmanlar; Kibar, B.S.; Pekcan, Sevgi; Hangül, Melih; Köse, Mehmet; Budakoğlu, Işıl İrem; Göktürk, Bahar

doi:10.1002/ppul.24690

Cited by 15 publications

(13 citation statements)

References 15 publications

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“…Some studies suggested that atopy could be associated with PIBO. 17,18,19,20 Similarly, in our study, approximately 20% of our patients had atopy.…”

Section: Discussionsupporting

confidence: 80%

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Yazan¹,

Khalif²,

Shadfan³

et al. 2020

Preprint

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Objective: This study aims to evaluate clinical and radiological findings and treatment outcomes of the patients with PIBO. Methods: One hundred fourteen children were enrolled. Initial demographic and clinical findings were evaluated.Pre-and post-treatment symptoms, radiological findings and scores, the number of admissions to the hospital and PICU were compared. Results: Seventy-three patients were male. The median age of the patients at initial pulmonary injury was 7.2 months, the median age at diagnosis was 17.5 months and the median interval from initial injury to diagnosis was 8.5 months. Thirty-five patients had mechanical ventilation history. Persistent wheezing was the most common complaints. The most common radiological findings were peribronchial thickening and air-trapping. Sixty-eight patients were treated with inhaled corticosteroid (IC), systemic corticosteroid (SC) and azithromycin (AZT) combination. 25 patients were treated with only IC, 14 with IC and AZT, and 7 with IC and SC. 82,5% of patients had clinical improvement. Chronic respiratory failure occurred in 11 patients, and three patients died. Bronchiectasis, atelectasis, hyperinflation and air trapping in HRCT improved significantly. Bhalla scores decreased from 8.3 to 6.5 (p= 0,001). IC, SC and AZT combination was effective than the other treatments. Conclusions: This study is one of the largest studies in the literature and one of the few studies that evaluate clinical and radiological outcomes. We found that IC, AZT and SC combination is clinically and radiologically effective in patients with PIBO.

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“…Some studies suggested that atopy could be associated with PIBO. 17,18,19,20 Similarly, in our study, approximately 20% of our patients had atopy.…”

Section: Discussionsupporting

confidence: 80%

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Yazan¹,

Khalif²,

Shadfan³

et al. 2020

Preprint

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“…In the current study, we found that although the proportion of children with RMPP pneumonia complicated with in uenza infection was higher than that of non-BO children, multivariate regression analysis found that in uenza infection was not a risk factor for the development of BO after RMPP. It is widely known that adenovirus infection is one of the risk factors for the development of BO in children [20]. In the current study, we did not nd an association between adenovirus co-infection and the development of BO after RMPP, which may be related to the small sample size.…”

Section: Discussioncontrasting

confidence: 78%

Clinical Features and Risk Factors Analysis of Bronchitis Obliterans Due to Refractory Mycoplasma Pneumoniae Pneumonia in Children: A Nomogram Prediction Model

Cheng

Zhang

Shang

et al. 2021

Preprint

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BackgroundEarly prediction of bronchitis obliterans (BO) is of great significance to the improvement of the long-term prognosis of children caused by refractory mycoplasma pneumoniae pneumonia (RMPP). This study aimed to establish a nomogram model to predict the risk of BO in children due to RMPP.MethodsA retrospective observation was conducted to study the clinical data of children with RMPP (1-14 years old) during acute infection. According to whether there is BO observed in the bronchoscope, children were divided into BO and the non-BO groups. The multivariate logistic regression model was used to construct the nomogram model.Results141 children with RMPP were finally included, of which 65 (46.0%) children with RMPP were complicated by BO. According to the multivariate logistic regression analysis, WBC count, ALB level, consolidation range exceeding 2/3 of lung lobes, timing of macrolides, glucocorticoids or fiber bronchoscopy and plastic bronchitis were independent influencing factors for the occurrence of BO and were incorporated into the nomogram. The area under the receiver operating characteristic curve (AUC-ROC) value of nomogram was 0.899 (95% confidence interval [CI]: 0.848~0.950). The Hosmer-Lemeshow test showed good calibration of the nomogram (p=0.692).Conclusion: A nomogram model found by seven risk factor was successfully constructed and can use to early prediction of children with BO due to RMPP.

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“…In the current study, we found that although the proportion of children with RMPP pneumonia complicated with influenza infection was higher than that of non-BO children, multivariate regression analysis found that influenza infection was not a risk factor for the development of BO after RMPP. It is widely known that adenovirus infection is one of the risk factors for the development of BO in children [ 20 ]. In the current study, we did not find an association between adenovirus co-infection and the development of BO after RMPP, which may be related to the small sample size.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and risk factors analysis of bronchitis obliterans due to refractory Mycoplasma pneumoniae pneumonia in children: a nomogram prediction model

et al. 2021

View full text Add to dashboard Cite

Background Early prediction of bronchitis obliterans (BO) is of great significance to the improvement of the long-term prognosis of children caused by refractory Mycoplasma pneumoniae pneumonia (RMPP). This study aimed to establish a nomogram model to predict the risk of BO in children due to RMPP. Methods A retrospective observation was conducted to study the clinical data of children with RMPP (1–14 years old) during acute infection. According to whether there is BO observed in the bronchoscope, children were divided into BO and the non-BO groups. The multivariate logistic regression model was used to construct the nomogram model. Results One hundred and forty-one children with RMPP were finally included, of which 65 (46.0%) children with RMPP were complicated by BO. According to the multivariate logistic regression analysis, WBC count, ALB level, consolidation range exceeding 2/3 of lung lobes, timing of macrolides, glucocorticoids or fiber bronchoscopy and plastic bronchitis were independent influencing factors for the occurrence of BO and were incorporated into the nomogram. The area under the receiver operating characteristic curve (AUC-ROC) value of nomogram was 0.899 (95% confidence interval [CI] 0.848–0.950). The Hosmer–Lemeshow test showed good calibration of the nomogram (p = 0.692). Conclusion A nomogram model found by seven risk factor was successfully constructed and can use to early prediction of children with BO due to RMPP.

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Postinfectious bronchiolitis obliterans masked by misdiagnosis as asthma

Cited by 15 publications

References 15 publications

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Clinical Features and Risk Factors Analysis of Bronchitis Obliterans Due to Refractory Mycoplasma Pneumoniae Pneumonia in Children: A Nomogram Prediction Model

Clinical features and risk factors analysis of bronchitis obliterans due to refractory Mycoplasma pneumoniae pneumonia in children: a nomogram prediction model

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