Postirradiation Hearing Loss

Talmi, Yoav P.; Finkelstein, Yehuda; Zohar, Yuval

doi:10.3109/00206098909081617

Cited by 34 publications

(9 citation statements)

References 16 publications

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“…Sensorineural HL can result from RT to the head and neck region at doses as low as 30 Gy 3 . Increasing losses occur with increasing doses such that at least one in three patients receiving a cranial dose of 70 Gy in 2 Gy per fraction develops HL of 10 dB or more at 4 kHz 1 …”

Section: Discussionmentioning

confidence: 99%

“…Sensorineural HL can result from RT to the head and neck region at doses as low as 30 Gy. 3 Increasing losses occur with increasing doses such that at least one in three patients receiving a cranial dose of 70 Gy in 2 Gy per fraction develops HL of 10 dB or more at 4 kHz. 1 NPC is a good clinical model for us to study the effects of irradiation on the auditory pathways because 1) it is a common disease in this part of the world, occurring mainly in Chinese, 2) in early stage cancers, the primary disease is treated by RT alone with many patients surviving many years after treatment, and 3) relatively high doses of radiation are used in standard treatment regimes, and the ear structures are included in the radiation fields.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Radiotherapy on Retro-Cochlear Auditory Pathways

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Radiotherapy on Retro-Cochlear Auditory Pathways

et al. 2005

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“…RT can cause both early and late onset SNHL. Early onset SNHL can occur during the therapy itself or shortly after its completion 5 and is usually partially or completely reversible. 6 Late onset SNHL occurs few months or years after therapy completion.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Hearing Loss in Patients Receiving Chemoradiotherapy in Adjuvant Setting for Head and Neck Malignancy

Gupta

Bhat

Rao

et al. 2020

Annals of Otology and Neurotology

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Introduction The aim of the study is to assess the hearing loss in patients who receive chemoradiation (chemoradiotherapy or CTRT) for head and neck malignancies. Materials and Methods Prospective study was conducted in the Department of ENT of a tertiary care center from September 2013 to August 2014. Forty patients suffering from head and neck malignancies (histologically proven) were included in the study. Patients with pre-existing hearing loss were excluded. All patients received radiotherapy dose of 66 to 70 Gy given as 2 Gy/d, 5 d/wk and chemotherapy dose of cisplatin 35 mg/m2 once a week for 6 weeks. Hearing was assessed by pure tone audiometry (PTA) and impedance audiometry conducted at regular intervals. Mcnemars chi-square test was used to compare the impedance and paired t-test and Pearson’s correlation were used to compare PTA at various stages. Results Predominantly male patients (28) falling in the age group of 40 to 60 years, suffered from various head and neck cancer, most common being oropharynx (14). Twenty patients developed sensorineural hearing loss (SNHL)—11(55%) had mild, seven (35%) had moderate, and two (10%) had severe grade of SNHL. Majority of these patients, 12 (60%) started developing SNHL mid-therapy, five (25%) at the completion of therapy and three (15%) 3 months post-therapy. Hearing loss was found to be more with two-dimensional radiotherapy (2DRT) and three-dimensional radiotherapy (3DRT) than with intensity-modulated radiotherapy (IMRT) as assessed by serial PTA. The average dose of radiation to right and left ears, respectively were 27.10 and 24.66 Gy. The incidence of otitis media with effusion increased during the treatment accounting for the conductive hearing loss irrespective of the modality of radiation used. Conclusion CTRT causes significant hearing loss in patients suffering from head and neck malignancies leading to further increase in the morbidity. Screening audiological assessment would be helpful to know the pretherapy status of the ear. Using newer modalities like IMRT can reduce hearing loss. Regular audiological screening can catch it at its onset and help in early use of hearing aids.

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“…As to the dose which is damaging to the organ of Corti, the higher the irradiation dose to the inner ear, the greater is the likelihood of an auditory damage 9 . In general, the total radiation dose necessary to damage the auditory system varies between 3,000 and 6,000 cGy, when divided in small fractions [10][11][12] . In our study, the dose necessary to cause immediate damage to the hair cells was 350cGy, applied in a single dose.…”

Section: Turn 3 -Rows 1 2 Andmentioning

confidence: 99%