Postirradiation morphea: an underrecognized complication of treatment for breast cancer

Walsh, Noreen; Rheaume, D.; Barnes, Penelope J; Tremaine, Robert; Reardon, Michael J.

doi:10.1016/j.humpath.2008.04.010

Cited by 46 publications

(56 citation statements)

References 22 publications

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“…14 In the literature few other skin disease associated with PIM were reported such as 2 cases with PIM and lichen sclerosus et atrophicans. 18 One patient developed PIM with subcutaneous polyarteritis nodosa. 17 It is believed that systemic sclerosis is a relative risk factor for developing an exaggerated post-irradiation fibrosis.…”

Section: Resultsmentioning

confidence: 99%

“…14 The treatment options are similar to those for idiopathic morphea which includes oral and systemic antibiotics, topical, intralesional and systemic corticosteroids. Multiple treatments for PIM with varying degrees of success have been achieved using topical steroids, 6,14,18 topical hyaluronidase 21 and methotrexate. 4 One patient mildly improved using phonophoresis with hyaluronidase and PUVA bath therapy.…”

Section: Discussionmentioning

confidence: 99%

“…21 Another case improved with potent topical steroids and showed gradual softening of the involved skin over a 5-year-period but the dermatologist was not convinced that the clinical improvement was therapy related. 18 In the literature, several studies reported about the effectiveness of the combination treatment of calcipotriol and UVA1 irradiation to treat morphea. 22 Furthermore, it was shown that the treatment of morphea with UVA1 showed a reduction in sclerotic plaques, an increase in skin elasticity and a reduction of lesional skin thickness.…”

Section: Discussionmentioning

confidence: 99%

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Post-Irradiation Morphea: Case report and review of the literature

Alhathlool

Hein²,

Andrés³

et al. 2012

J Dermatol Case Rep

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Background/Purpose: Post-irradiation morphea (PIM) is an entity documented in the literature although still not mentioned in most of the dermatological textbooks with a frequency approximately 2 out of every 1000 patients who received radiotherapy. Most of the cases are misdiagnosed as recurrent or metastatic carcinoma. Main observations:We report on a 64-year-old woman who was treated with radiotherapy for breast cancer. Two years and eight months after the first dose of radiotherapy, she developed localized morphea in the irradiated area. Conclusion:We report on a new case with a literature review and discuss pathogenesis, treatment modalities and post irradiation subcutaneos reactions mimicking PIM. Around 54 cases of post-irradiation morphea (PIM) were identified in the literature. (J Dermatol Case Rep. 2012; 6(3): 73-77)

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Post-Irradiation Morphea: Case report and review of the literature

Alhathlool

Hein²,

Andrés³

et al. 2012

J Dermatol Case Rep

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“…Furthermore, morphea of the breast occasionally occurs in female patients without a history of irradiation and of carcinoma [31]. Table 1 summarizes the cases of postradiogenic morphea published since 1989 (expanded in accordance with Walsh et al [38]; older cases also in Ullén & Björkholm [36]). One thing which stands out is the fact that this radiation reaction occurs unusually frequently among patients with breast cancer.…”

Section: Discussionmentioning

confidence: 90%

Localized Morphea – a Rare but Significant Secondary Complication Following Breast Cancer Radiotherapy

2009

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The occurrence of morphea is an unexpected late effect (approximately 1 year after the end of radiation therapy) which occurs frequently in the irradiated breast in women with breast-conserving therapy. The pathogenesis is unclear. The main differential diagnoses are recurrence of carcinoma and a radiogenic subcutaneous fibrosis (in most cases, the final diagnosis can only be made by means of a biopsy). Diagnosis and therapy must be performed in cooperation between dermatologist and radiooncologist.

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“…Sometimes the subcutaneous fat is involved, showing a mixed lobular and septal panniculitis. In idiopathic morphea profunda, the dominant pattern is only a septal panniculitis [6,7]. …”

Section: Discussionmentioning

confidence: 99%

Irradiation-Induced Morphea: X-Rays as Triggers of Autoimmunity

Laetsch

Hofer²,

Lombriser³

et al. 2011

Dermatology

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We report on 3 females with breast cancer who developed morphea at the site of post-surgery radiotherapy. One was suffering from other autoimmune skin diseases before the diagnosis and treatment of breast cancer. Postirradiation morphea is a potential complication after radiotherapy, particularly radiotherapy for cancer. This troublesome skin disease can occur months to years after treatment, and is associated with remarkable morbidity and pain, and also cosmetic aspects. Therefore, it is crucial to be aware of this condition, and to try to identify patients who might be at an increased risk of developing morphea.

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Postirradiation morphea: an underrecognized complication of treatment for breast cancer

Cited by 46 publications

References 22 publications

Post-Irradiation Morphea: Case report and review of the literature

Post-Irradiation Morphea: Case report and review of the literature

Localized Morphea – a Rare but Significant Secondary Complication Following Breast Cancer Radiotherapy

Irradiation-Induced Morphea: X-Rays as Triggers of Autoimmunity

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