Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes

Çolak, Ayfer; Akıncı, Barış; Dınız, Gülden; Türkön, Hakan; Ergonen, Faruk; Yalçın, Hülya; Çoker, Işıl

doi:10.3109/00365513.2013.798870

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…Moreover, patients with a history of severe hypoglycaemia have high associated risks of cardiovascular disease and all‐cause mortality . Furthermore, both hyperglycaemia and hypoglycaemic episodes may trigger an inflammatory reaction and procoagulant response . Such glucose fluctuation activates oxidative stress, which leads to cellular damage.…”

Section: Discussionmentioning

confidence: 99%

“…34,35 Furthermore, both hyperglycaemia and hypoglycaemic episodes may trigger an inflammatory reaction and procoagulant response. 36,37 Such glucose fluctuation activates oxidative stress, 38 which leads to cellular damage. According to such reports, glycaemic variability may be involved in the mechanism underlying the negligible effect of intensive glucose control on mortality risk.…”

Section: T a B L E 1 Baseline Characteristics Of The Study Subjectsmentioning

confidence: 99%

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Effect of mean HbA1c on the association of HbA1c variability and all‐cause mortality in patients with type 2 diabetes

Tseng

Chen

Huang

et al. 2020

Diabetes Obesity Metabolism

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Aim To evaluate the effect of mean HbA1c on the correlation between HbA1c variability and all‐cause mortality, and the risks associated with different levels of HbA1c and glycaemic control status in patients with type 2 diabetes. Materials and Methods Patients with type 2 diabetes and at least three HbA1c measurements within 12–24 months were included. HbA1c variability score, coefficient of variation (CV) and standard deviation (SD) were used to evaluate variability. A variability score of 50 was set as a cutoff to define low and high variability. Results A total of 4216 patients were included, of whom 1196 died during the observation period (11.1 ± 3.2 years). All‐cause mortality increased with HbA1c variability score and the quartiles of HbA1c CV and SD. The strength of this association was attenuated after adjustment for mean HbA1c, and the risks associated with HbA1c variability and glycaemic control status were similar. The highest associated risk was observed with an HbA1c variability score of >50 and mean HbA1c of ≥7.5%. Mortality risk was significantly higher with a mean HbA1c of ≤6.0% and >8.5% and of ≤6.0% and >8.0% for low and high HbA1c variability, respectively. Conclusions Mean HbA1c contributed to the correlation between HbA1c variability and all‐cause mortality. The risks associated with HbA1c variability and glycaemic control status were similar. The relationship between mean HbA1c and mortality presented a J‐shaped distribution for both low and high HbA1c variability.

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Section: Discussionmentioning

confidence: 99%

Section: T a B L E 1 Baseline Characteristics Of The Study Subjectsmentioning

confidence: 99%

Effect of mean HbA1c on the association of HbA1c variability and all‐cause mortality in patients with type 2 diabetes

Tseng

Chen

Huang

et al. 2020

Diabetes Obesity Metabolism

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“…The state of chronic inflammation and oxidative stress that obesity has been associated with is believed to play a role in promoting obesity-related complications such as insulin resistance and type-2 diabetes (Hardy, Czech, & Corvera, 2012; Hotamisligil, 2006). Another common metabolic attribute linked to obesity is hyperglycaemia (Ferguson, Gallagher, Scheinman, Damouni, & Leroith, 2013; Hardy et al, 2012), which in turn has been associated with the precipitation of oxidative stress and inflammation (Colak et al, 2013; Dey & Lakshmanan, 2013), thus further increasing diabetic risks and complications (Giacco & Brownlee, 2010; Henriksen, Diamond-Stanic, & Marchionne, 2011; Zatalia & Sanusi, 2013). It is hence of no surprise that diabetes currently affects 29.1 million people in the U.S. and the number of Americans with prediabetes is on the rise.…”

Section: Introductionmentioning

confidence: 99%

α-Glucosidase inhibiting activity and bioactive compounds of six red wine grape pomace extracts

Kadouh

Sun

Zhu

et al. 2016

Journal of Functional Foods

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Grape pomace contains considerable amounts of polyphenols and it has been reported to exhibit specific inhibitory activity against mammalian intestinal α-glucosidases. This study aims to investigate the anti-diabetes potential of Chambourcin, Merlot, Norton, Petit Verdot, Syrah and Tinta Cão red wine grape pomaces by assessing their rat intestinal α-glucosidase inhibitory activity in relation to their total phenolic content and individual identified phenolic compounds by HPLC. Among the selected pomaces, Tinta Cão, Syrah and Merlot extracts showed higher potency in inhibiting α-glucosidase, and appeared to have higher respective total phenolic contents. Fifteen phenolic compounds were identified in the pomace samples, however, none of them showed significant inhibition of intestinal α-glucosidases. Red grape pomace, namely Tinta Cão, appears to be a promising functional food for the potential future development of a food-derived α-glucosidase inhibitor for preventing and treating diabetes.

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“…it is likely that the increased PIK3CD mRNA level in the diabetic patients could be due to inflammation state induced directly by hyperglycaemia [29,30]. According to this assumption, it has been reported that PI3-K delta affects different cellular functions of leukocytes, and its inactivation leads to impaired inflammatory and immune responses [8].…”

Section: Prace Oryginalnementioning

confidence: 99%

Związek podwyższonej ekspresji leukocytarnej kinazy 3-fosfatydyloinozytolu delta z cukrzycą ciążową (GDM)

Wójcik¹,

Mac-Marcjanek²,

Woźniak³

et al. 2014

Endokrynologia Polska

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Introduction: An increasing body of evidence has linked diabetes to inflammation. The phosphatidylinositol 3-kinase delta (PI3-K delta), a member of the PI3K class IA family, has been implicated in the regulation of inflammation since it is predominantly expressed in leukocytes. To date, no information has been available on the relationship of leukocyte PI3-K delta with gestational diabetes mellitus (GDM). Therefore, the aim of this study was to investigate changes in leukocyte PIK3CD mRNA expression in GDM women and, in turn, to correlate them with anthropometric and metabolic parameters of patients. Additionally, an association between leukocyte mRNA expression of PIK3CD and Sirtuin 1 (SIRT1) was determined. Material and methods: Blood samples from women with normal glucose tolerance (NGT; n = 43) and GDM (n = 132) at 24-33 weeks of gestation were collected. After isolating leukocytes from the blood, quantitative real time PCR (qRT-PCR) was performed to determine PIK3CD gene expression in these cells. Univariate regression analyses were used to assess an association of leukocyte PIK3CD mRNA level with clinical characteristics of patients as well as with leukocyte SIRT1 mRNA expression. Results: Leukocyte PIK3CD mRNA was increased by 1.98-fold in the GDM v. NGT subjects and inversely correlated with low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in diabetic pregnancy. There were also significant positive correlations of leukocyte PIK3CD mRNA with plasma glucose concentration at 2h of 75 g oral glucose tolerance test (OGTT) and SIRT1 mRNA in the whole study population (both P < 0.05). Conclusions: GDM is accompanied by leukocyte PIK3CD overexpression associated with reduced plasma LDL-C and TC levels, as well as with hyperglycaemia and elevated leukocyte SIRT1 mRNA. (Endokrynol Pol 2014; 65 (1): 17-24)

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Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes

Abstract: Our results suggest that patients with prediabetes, independent of underlying obesity, have increased concentrations of subclinical inflammation which is mostly driven by postload glucose concentrations.

Cited by 17 publications

References 24 publications

Effect of mean HbA1c on the association of HbA1c variability and all‐cause mortality in patients with type 2 diabetes

Effect of mean HbA1c on the association of HbA1c variability and all‐cause mortality in patients with type 2 diabetes

α-Glucosidase inhibiting activity and bioactive compounds of six red wine grape pomace extracts

Związek podwyższonej ekspresji leukocytarnej kinazy 3-fosfatydyloinozytolu delta z cukrzycą ciążową (GDM)

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