Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report

Adefris, Mulat; Fekadu, Elfalet

doi:10.1186/s13256-017-1411-3

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…Serum testosterone levels of premenopausal patients were higher in those with GCTs. Previous cases of testosterone-producing GCTs have also been reported [ 28 , 29 ]. FSH receptors are present in granulosa cells, and FSH induces the conversion of androgens to estrogen in granulosa cells.…”

Section: Discussionmentioning

confidence: 99%

Serum FSH as a Useful Marker for the Differential Diagnosis of Ovarian Granulosa Cell Tumors

Matsuoka

Tate

Nishikimi

et al. 2022

Cancers

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Background: We evaluated whether the serum hormone levels are useful in the differential diagnosis of granulosa cell tumors (GCTs), regardless of menopausal status. Methods: Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, and progesterone were measured preoperatively in all patients (n = 471) who underwent surgery for ovarian tumors at Chiba University Hospital between 2009 and 2021. These were compared in two groups, a GCT group (n = 13) and a group with other histological types (non-GCT) (n = 458). Results: The GCT group had significantly lower serum LH and FSH (p = 0.03 and p < 0.001, respectively) and significantly higher testosterone, estradiol, and progesterone (p < 0.001, p < 0.001, and p = 0.045, respectively) than the non-GCT group. Multivariate analysis revealed that serum FSH and estradiol were significantly associated with GCT (FSH, odds ratio (OR) = 0.0046, 95% confidence interval (CI) = 0.0026–0.22, p = 0.004; estradiol, OR = 0.98, 95% CI = 0.96–0.998, p = 0.046). Receiver-operating characteristic curve analysis for GCTs showed that the area under the curve of serum FSH was 0.99, with a sensitivity of 100% and a specificity of 98%, when the cutoff level was set at 2.0 IU/L. Conclusions: Preoperative serum FSH level is an extremely useful marker for differentiating GCTs from all ovarian tumors.

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Section: Discussionmentioning

confidence: 99%

Serum FSH as a Useful Marker for the Differential Diagnosis of Ovarian Granulosa Cell Tumors

Matsuoka

Tate

Nishikimi

et al. 2022

Cancers

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“…Other sex-cord stromal tumors, such as granulosa cell tumors and steroid cell tumors, have also been reported in association with virilization and hirsutism, although these cases are extremely rare [ 28 , 29 ].…”

Section: Ovarian Causes Of Hirsutismmentioning

confidence: 99%

Imaging features of intra-abdominal and intra-pelvic causes of hirsutism

Li,

Bloomgarden,

Friedman

et al. 2024

Abdom Radiol

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Hirsutism is a relatively common disorder which affects approximately 5% to 15% of women. It is defined by excessive growth of terminal hair in women, which primarily affects areas dependent on androgens, such as the face, abdomen, buttocks, and thighs. Hirsutism can be caused by a variety of etiologies, which are most often not lifethreatening. However, in some cases, hirsutism can be an indicator of more serious underlying pathology, such as a neoplasm, which may require further elucidation with imaging. Within the abdomen and pelvis, adrenal and ovarian pathologies are the primary consideration. The goal of this manuscript is to review the etiologies and imaging features of various intra-abdominal and intra-pelvic causes of hirsutism.

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“… / / / 6 months to date without recurrence. 2017 Mulat Adefris 19 1 50 Hirsutism and hyperandrogenemia. GCT c I TAH-BSO g resection of the mass, infracolic omentectomy, and right pelvic lymph node sampling.…”

Section: Introductionmentioning

confidence: 99%

Oncological Prognosis and Fertility Outcomes of Different Surgical Extents for Malignant Ovarian Sex-Cord Stromal Tumors: A Narrative Review

J¹,

Jiang²

2022

CMAR

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Background Malignant ovarian sex-cord stromal tumors (MOSCSTs) are rare neoplasms that account for approximately 5–7% of all ovarian malignancies. The majority (70%) of patients had an early stage; thus, surgery is the predominant treatment. Patients were relatively young at the onset of the tumor. Moreover, the prognosis of patients with this tumor is better than that of malignant epithelial ovarian tumors and tends to recur late with an indolent clinical course. Thus, patients may be more inclined to conservative surgical procedures. There is, however, no objective criterion for selecting a suitable surgical procedure. Clinically, surgical extent depended on the preoperative evaluations, age, and willingness of patients, and gynecologists were relatively subjective when choosing surgery. The prognosis of patients with different surgical extents is still controversial. The review aimed to summarize the impacts of different surgical extents on oncological prognosis and fertility outcomes. Methods The literature search was performed in PubMed ( https://www.ncbi.nlm.nih.gov/pubmed/ ), and publications between January 2011 and December 2021 in English including clinical cohort studies and case reports were eligible for inclusion. Results We finally identified 12 large-sample retrospective studies and 18 cases of MOSCSTs. The primary surgical procedures include fertility-spring surgery (FSS), total hysterectomy with unilateral or bilateral salpingo-oophorectomy (TAH-USO/BSO), FSS with complete staging procedure, complete staging surgery (CSS), and debulking surgery. FSS includes cystectomy (CYS), unilateral salpingo-oophorectomy (USO) or bilateral salpingo-oophorectomy (BSO) with uterine preservation that allows for potential future assisted reproductive approaches. Complete staging procedure includes peritoneal cytologic examinations, inspections of peritoneal surfaces, random peritoneal biopsies and omentectomy. FSS with complete staging procedure means surgical procedure with uterine preservation and complete staging procedure. And, generally, CSS means TAH-BSO with complete staging procedure. Conclusion It can be concluded that USO can be done in young, fertility-desired patients with tumors confined to the ovary but avoid CYS. FSS with complete staging procedure is feasible among stage IC-III patients who have fertility desire. Patients can choose to have a complete surgery once their family is complete or without fertility requirements. CSS is recommended for patients with risk factors such as high stage, poor differentiation, and large tumor size and without fertility desire. A close follow-up is essential.

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Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report

Cited by 10 publications

References 8 publications

Serum FSH as a Useful Marker for the Differential Diagnosis of Ovarian Granulosa Cell Tumors

Serum FSH as a Useful Marker for the Differential Diagnosis of Ovarian Granulosa Cell Tumors

Imaging features of intra-abdominal and intra-pelvic causes of hirsutism

Oncological Prognosis and Fertility Outcomes of Different Surgical Extents for Malignant Ovarian Sex-Cord Stromal Tumors: A Narrative Review

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