Postmenopausal osteoporosis: current status of bone densitometry

Testini, Valentina; Paparella, Maria Teresa; Gangai, Ilaria; Guglielmi, Giuseppe

doi:10.23736/s2724-606x.20.04674-2

Cited by 5 publications

(3 citation statements)

References 80 publications

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“…Criteria. Inclusion criteria were as follows: (1) patients were diagnosed with primary osteoporosis according to the biochemical examination of bone metabolism in accordance with the diagnostic criteria of osteoporosis recommended by the International Society of Clinical Densitometry (ISCD) [10] and American college of radiology [11]. (2) Patients had the clinical manifestations with spontaneous pain in the whole body, waist, thorax, and back.…”

Section: Inclusion and Exclusionmentioning

confidence: 99%

Effects of Pamidronate Disodium Combined with Calcium on BMD Values and Severity of Pain in Elderly Patients with Osteoporosis Based on Mobile Terminal Platform for Internet of Things

et al. 2022

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Objective. To explore the effects of pamidronate disodium combined with calcium on BMD values and the severity of pain in elderly patients with osteoporosis based on the mobile terminal platform for the Internet of Things. Methods. The data of 120 patients admitted to our hospital from January 2019 to December 2020 were retrospectively analyzed. According to the patients’ condition and medication wills, they were divided into the experimental group ( n = 68 ) and the control group ( n = 52 ). All patients were given chronic disease management based on the mobile terminals for the Internet of Things, and they received the treatment of bisphosphonates and calcium, with the supplement of calcium at a daily dose of 1000 mg. The control group was given alendronate sodium once a week, and the experimental group was given pamidronate disodium by intravenous infusion three times a month, with the treatment cycle as 1 year. The patients’ bone mineral density (BMD) values and the pain indexes were compared after treatment. Results. There was no statistical difference in general information between the two groups ( p > 0.05 ). The BMD values of the lumbar vertebrae L2-4, total hip, and femur neck at 6 months and 1 year after treatment in the experimental group were significantly higher than those in the control group ( p < 0.001 ). The pain scores at 6 months and 1 year after treatment in the experimental group were significantly lower than those in the control group ( p < 0.001 ). Conclusion. The treatment of pamidronate disodium combined with calcium based on the mobile terminal platform for the Internet of Things can reduce the severity of pain in elderly patients with osteoporosis and improve the BMD, which has a generalization value.

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Section: Inclusion and Exclusionmentioning

confidence: 99%

Effects of Pamidronate Disodium Combined with Calcium on BMD Values and Severity of Pain in Elderly Patients with Osteoporosis Based on Mobile Terminal Platform for Internet of Things

et al. 2022

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“…Epidemiological investigations have shown that the prevalence of OP is 18.3% worldwide, and 44.3% of OP patients may suffer fragility fracture within 10 years. − Osteoporotic fractures weaken the ability of bone to heal and regenerate, leading to delayed bone healing, bone nonunion, and even bone defects. Meanwhile, osteoporotic fractures bring a heavy burden to the patient’s family and the country. − Autologous bone transplantation is the gold standard treatment for osteoporotic bone defects, but its limited source affects the disease treatment effect in clinical practice. − …”

Section: Introductionmentioning

confidence: 99%

Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway

Zhu

Jia

Yang

et al. 2023

ACS Biomater. Sci. Eng.

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In this study, biomimetic porous magnesium alloy scaffolds were prepared to repair femoral bone defects in ovariectomized osteoporotic rats. The purpose of the study was to investigate the effect of biomimetic porous magnesium alloy scaffolds on repairing osteoporotic bone defects and possible mechanisms. The animal model of osteoporosis was established in female SD rats. Three months later, a bone defect of 3 mm in diameter and 3 mm in depth was created in the lateral condyle of the right femur. The rats were then randomly divided into two groups: an experimental group and a control group. Four weeks after surgery, gross specimens were observed and micro-CT scans were performed. The repair of osteoporotic femoral defects in rats was studied histologically using HE staining, Masson staining, and Goldner staining. The expression of Wnt5a, β-catenin, and BMP-2 was measured between groups by immunohistochemical staining. The bone defect was repaired better after the application of biomimetic porous magnesium alloy scaffolds. Immunohistochemical results showed significantly higher expression of Wnt5a, β-catenin, and BMP-2. To conclude, the biomimetic porous magnesium alloy scaffolds proposed in this paper might promote the repair of osteoporotic femoral bone defects in rats possibly through activating the Wnt/β-catenin signaling pathway.

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“…e serious clinical outcome of osteoporosis is osteoporotic fractures (fragility fractures), which lead to a signi cant increase in morbidity and mortality in patients with osteoporosis [2]. e treatments for osteoporosis include the following: (1) basic prevention, such as lifestyle adjustment (diet and outdoor sports) and basic bone health supplements (calcium and vitamin D); (2) drug interventions, such as antibone resorption drugs (bisphosphonates, calcitonin, selective estrogen receptor modulators (SERMs), and estrogen); (3) drugs that promote bone formation, such as targeted drugs [2][3][4]. However, recent studies showed that the preventive and therapeutic e ects of the above drugs are still controversial, such as vitamin D [5], while antibone resorption drugs increase the burden of medical resources and reduce patient compliance due to their high price [6].…”

Section: Introductionmentioning

confidence: 99%

Research on the Mechanism of Liuwei Dihuang Decoction for Osteoporosis Based on Systematic Biological Strategies

Long

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Osteoporosis is an important health problem worldwide. Liuwei Dihuang Decoction (LDD) and its main ingredients may have a good clinical effect on osteoporosis. Meanwhile, its mechanism for treating osteoporosis needs to be further revealed in order to provide a basis for future drug development. Methods. A systematic biological methodology was utilized to construct and analyze the LDD-osteoporosis network. After that, the human transcription data of LDD intervention in patients with osteoporosis and protein arrays data of LDD intervention in osteoporosis rats were collected. The human transcription data analysis, protein arrays data analysis, and molecular docking were performed to validate the findings of the prediction network (LDD-osteoporosis PPI network). Finally, animal experiments were conducted to verify the prediction results of systematic pharmacology. Results. (1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β-catenin mRNA expression ( P < 0.05 ). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1. Conclusion. LDD may have a therapeutic effect on osteoporosis through regulating the targets (such as ALB, IGF1, SRC, and ESR1), biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) found in this research.

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Postmenopausal osteoporosis: current status of bone densitometry

Cited by 5 publications

References 80 publications

Effects of Pamidronate Disodium Combined with Calcium on BMD Values and Severity of Pain in Elderly Patients with Osteoporosis Based on Mobile Terminal Platform for Internet of Things

Effects of Pamidronate Disodium Combined with Calcium on BMD Values and Severity of Pain in Elderly Patients with Osteoporosis Based on Mobile Terminal Platform for Internet of Things

Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway

Research on the Mechanism of Liuwei Dihuang Decoction for Osteoporosis Based on Systematic Biological Strategies

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