2015
DOI: 10.1016/j.theriogenology.2015.05.037
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Postmortem findings in cloned and transgenic piglets dead before weaning

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Cited by 33 publications
(44 citation statements)
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“…Abnormal reprogramming of cloned embryos or incomplete embryonic development during pregnancy can account for the early death of cloned animals (Carter et al 2002). Therefore, cloned pigs have high deformity rate and mortality produced by SCNT, and the death of cloned piglets is n■ generally high (58%) before weaning (Liu et al 2015;Schmidt et al 2015). Our results indicated that KI (2 out 4) and non-KI (3 out of 6) pigs had the same mortality rate of 50% that is similar to previous reports (Liu et al 2015;Schmidt et al 2015).…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…Abnormal reprogramming of cloned embryos or incomplete embryonic development during pregnancy can account for the early death of cloned animals (Carter et al 2002). Therefore, cloned pigs have high deformity rate and mortality produced by SCNT, and the death of cloned piglets is n■ generally high (58%) before weaning (Liu et al 2015;Schmidt et al 2015). Our results indicated that KI (2 out 4) and non-KI (3 out of 6) pigs had the same mortality rate of 50% that is similar to previous reports (Liu et al 2015;Schmidt et al 2015).…”
Section: Discussionsupporting
confidence: 88%
“…Therefore, cloned pigs have high deformity rate and mortality produced by SCNT, and the death of cloned piglets is n■ generally high (58%) before weaning (Liu et al 2015;Schmidt et al 2015). Our results indicated that KI (2 out 4) and non-KI (3 out of 6) pigs had the same mortality rate of 50% that is similar to previous reports (Liu et al 2015;Schmidt et al 2015). Traditionally, targeted insertions into the ROSA26 or H11 locus are frequently used for the constitutive or conditional expression of TG pigs (Jakobsen et al 2011;Li et al 2014;Lin et al 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, cloned pigs have high deformity rate and mortality produced by SCNT, and the loss of cloned piglets is generally high (58%) before weaning (Liu et al . 2015; Schmidt et al . 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Our results also showed a similar mortality rate (KI 50% (2/4), non-KI 40% (2/5)) as previous reports (Liu et al . 2015; Schmidt et al . 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Pig somatic cell nuclear transfer (SCNT) has valuable applications in agriculture, biomedicine, and life science (Matsunari & Nagashima, ; Yang & Wu, ). However, SCNT‐derived cloned pig fetuses frequently exhibit aberrant intrauterine development (Ao et al, ; Ao, Li, et al, ; Chae et al, ; Kim et al, ; Ruan et al, ), leading to high stillbirth occurrence (17–32.8%; Ao, Zhao, et al, ; Estrada et al, ; Huan et al, ; Kurome et al, ; Liu et al, ), congenital malformations (29.5–60.0%; Kurome et al, ; Schmidt, Winther, Secher, & Callesen, ), and neonatal mortality (48.0–74.5%; Ao et al, ; Park et al, ; Schmidt et al, ) in newborn cloned piglets. Nevertheless, available information regarding the causes of erroneous intrauterine development of cloned pig fetuses is extremely limited.…”
Section: Introductionmentioning
confidence: 99%