Postnatal Changes of Alpha‐foetoprotein, Albumin and Total Protein in Human Serum

Karlsson, Börje W.; Bergstrand, C. G.; Ekelund, H; Lindberg, Tor

doi:10.1111/j.1651-2227.1972.tb15916.x

Cited by 33 publications

(27 citation statements)

References 21 publications

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“…Furthermore, birthweight itself has been correlated with gestational age (r = -0.77) (17). AFP blood levels during development and in cord blood also show correlations with birthweight (r = -.065 and -0.61, respectively) but are less marked than with gestational age (17,25). We conclude that birthweight may serve as the ideal parameter upon which to measure AFP until gestational age can be established.…”

Section: Table 4 Calculation Of Apparent Half-life Of Alphajetoprotementioning

confidence: 83%

“…In fact, AFP concentrations in cord serum have been suggested as a parameter to measure gestational age (25); however, estimation of gestational age without sonography can be highly subjective and inaccurate whereas birthweight is a discrete quantitative measurement. Furthermore, birthweight itself has been correlated with gestational age (r = -0.77) (17). AFP blood levels during development and in cord blood also show correlations with birthweight (r = -.065 and -0.61, respectively) but are less marked than with gestational age (17,25).…”

Section: Table 4 Calculation Of Apparent Half-life Of Alphajetoprotementioning

confidence: 87%

“…Although the diagnostic specificity of AFP detection might appear diminished, the range of identifiable perinatal problems may actually be increased. The relatively high concentrations of alpha-fetoprotein in neonatal blood (17,41), as well as its potential clinical importance, make this fetal protein an exceptional candidate for measurement in newborn dried blood specimens.…”

Section: Discussionmentioning

confidence: 99%

“…It is likely that this is a reflection of gestational age because this latter parameter is well correlated with AFP blood levels (r = -0.82) during development (17). In fact, AFP concentrations in cord serum have been suggested as a parameter to measure gestational age (25); however, estimation of gestational age without sonography can be highly subjective and inaccurate whereas birthweight is a discrete quantitative measurement.…”

Section: Table 4 Calculation Of Apparent Half-life Of Alphajetoprotementioning

confidence: 99%

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Measurement of Serum Alpha-Fetoprotein in Early Infancy: Utilization of Dried Blood Specimens

et al. 1983

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Section: Table 4 Calculation Of Apparent Half-life Of Alphajetoprotementioning

confidence: 83%

Section: Table 4 Calculation Of Apparent Half-life Of Alphajetoprotementioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Table 4 Calculation Of Apparent Half-life Of Alphajetoprotementioning

confidence: 99%

See 2 more Smart Citations

Measurement of Serum Alpha-Fetoprotein in Early Infancy: Utilization of Dried Blood Specimens

et al. 1983

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“…T4 also reaches a peak during the first 24 h of life and then decreases progressively [13]. On the other hand, there is evidence that a-FP drops significantly in the first 10 postnatal hours reaching 20% of its initial concentration and continues to decrease, with a t./j of 5 days, the first 2 weeks of life [14].…”

Section: Discussionmentioning

confidence: 97%

α-Fetoprotein in Congenital Hypothyroidism

Mengreli

Sarafidou²,

Petmezaki³

et al. 1990

Neonatology

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α-Fetoprotein (α-FP) was measured in dried blood spots from normal, congenital hypothyroid (CH) and transient hyperthyrotropinemic (TH) newborns as well as in serum from CH and TH babies together with thyroxine, triiodothyronine and thyrotropin. The half-life of α-FP had a median value of 12 days in the CH cases and 4.9 days in the TH cases. α-FP was significantly higher in the CH group before treatment and showed a significant rise after discontinuation of thyroxine therapy. It would appear that thyroid hormones influence α-FP metabolism and that a hypothyroid environment results in increased α-FP levels.

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Serum α‐Fetoprotein Levels in Normal Infants

Lee,

Chang,

Chen

et al. 1989

J. pediatr. gastroenterol. nutr.

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Age‐dependent changes of serum α‐fetoprotein (AFP) levels were analyzed in 284 normal infants, including 113 full‐term neonates and 171 infants between 1–12 months old. Serial statistical analyses attempted to clarify some confusing and conflicting observations presently existing in the literature. The results showed the following: (a) variations of AFP values were homogeneous throughout infancy, after the logarithmic transformation that is essential in dealing with AFP data. (b) To obtain an approximately 95% prediction band of normal AFP levels in infancy, the regression analysis should be based on the power regression rather than the exponential progression model: log Y = 7.397 ‐ 2.622 · log (X + 10), where X = age in days and Y = AFP level in nanograms per milliliter. (c) A sex‐related difference existed with higher mean values for male babies between 2–4 days of age, a fact that may be missed with casual analysis. In addition, the mean AFP level was found to be relatively constant at some time during the 1st week of life, in contrast to its subsequent extremely rapid decline. These characteristic changes deserve further investigation.

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Postnatal Changes of Alpha‐foetoprotein, Albumin and Total Protein in Human Serum

Cited by 33 publications

References 21 publications

Measurement of Serum Alpha-Fetoprotein in Early Infancy: Utilization of Dried Blood Specimens

Measurement of Serum Alpha-Fetoprotein in Early Infancy: Utilization of Dried Blood Specimens

α-Fetoprotein in Congenital Hypothyroidism

Serum α‐Fetoprotein Levels in Normal Infants

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